气候变化领域集成服务门户(CCPortal): Toxigenic Vibrio cholerae evolution and establishment of reservoirs in aquatic ecosystems

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DOI	10.1073/pnas.1918763117
	Toxigenic Vibrio cholerae evolution and establishment of reservoirs in aquatic ecosystems
	Mavian C.; Paisie T.K.; Alam M.T.; Browne C.; de Rochars V.M.B.; Nembrini S.; Cash M.N.; Nelson E.J.; Azarian T.; Ali A.; Glenn Morris J.; Jr.; Salemi M.
发表日期	2020
ISSN	0027-8424
起始页码	7897
结束页码	7904
卷号	117 期号:14
英文摘要	The spread of cholera in the midst of an epidemic is largely driven by direct transmission from person to person, although it is well-recognized that Vibrio cholerae is also capable of growth and long-term survival in aquatic ecosystems. While prior studies have shown that aquatic reservoirs are important in the persistence of the disease on the Indian subcontinent, an epidemiological view postulating that locally evolving environmental V. cholerae contributes to outbreaks outside Asia remains debated. The single-source introduction of toxigenic V. cholerae O1 in Haiti, one of the largest outbreaks occurring this century, with 812,586 suspected cases and 9,606 deaths reported through July 2018, provided a unique opportunity to evaluate the role of aquatic reservoirs and assess bacterial transmission dynamics across environmental boundaries. To this end, we investigated the phylogeography of both clinical and aquatic toxigenic V. cholerae O1 isolates and show robust evidence of the establishment of aquatic reservoirs as well as ongoing evolution of V. cholerae isolates from aquatic sites. Novel environmental lineages emerged from sequential population bottlenecks, carrying mutations potentially involved in adaptation to the aquatic ecosystem. Based on such empirical data, we developed a mixed-transmission dynamic model of V. cholerae, where aquatic reservoirs actively contribute to genetic diversification and epidemic emergence, which underscores the complexity of transmission pathways in epidemics and endemic settings and the need for long-term investments in cholera control at both human and environmental levels. © 2020 National Academy of Sciences. All rights reserved.
语种	英语
scopus关键词	aquatic environment; Article; bacterial growth; bacterial transmission; bacterium carrier; bacterium isolate; empirical research; environmental factor; epidemic; genetic variability; mutation; nonhuman; phylogeography; prevention and control; priority journal; toxicity; Vibrio cholerae; Asia; bacterial genome; cholera; classification; ecosystem; genetics; Haiti; human; microbiology; pathogenicity; pathology; phylogeny; Vibrio cholerae O1; Asia; Cholera; Disease Outbreaks; Ecosystem; Genome, Bacterial; Haiti; Humans; Phylogeny; Vibrio cholerae O1; Water Microbiology
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/161006
作者单位	Mavian, C., Emerging Pathogens Institute, University of Florida, Gainesville, FL 32610, United States, Department of Pathology Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, United States; Paisie, T.K., Emerging Pathogens Institute, University of Florida, Gainesville, FL 32610, United States, Department of Pathology Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, United States; Alam, M.T., Emerging Pathogens Institute, University of Florida, Gainesville, FL 32610, United States; Browne, C., Mathematics Department, University of Louisiana, Lafayette, LA 70504, United States; de Rochars, V.M.B., Department of Pathology Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, United States, Department of Health Services Research Management and Policy, College of Public Health and Health Professions, University of Florida, Gainesville, FL 32610, U...
推荐引用方式 GB/T 7714	Mavian C.,Paisie T.K.,Alam M.T.,et al. Toxigenic Vibrio cholerae evolution and establishment of reservoirs in aquatic ecosystems[J],2020,117(14).
APA	Mavian C..,Paisie T.K..,Alam M.T..,Browne C..,de Rochars V.M.B..,...&Salemi M..(2020).Toxigenic Vibrio cholerae evolution and establishment of reservoirs in aquatic ecosystems.Proceedings of the National Academy of Sciences of the United States of America,117(14).
MLA	Mavian C.,et al."Toxigenic Vibrio cholerae evolution and establishment of reservoirs in aquatic ecosystems".Proceedings of the National Academy of Sciences of the United States of America 117.14(2020).