气候变化领域集成服务门户(CCPortal): The impact of long-range dispersal on gene surfing

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DOI	10.1073/pnas.1919485117
	The impact of long-range dispersal on gene surfing
	Paulose J.; Hallatschek O.
发表日期	2020
ISSN	0027-8424
起始页码	7584
结束页码	7593
卷号	117 期号:14
英文摘要	Range expansions lead to distinctive patterns of genetic variation in populations, even in the absence of selection. These patterns and their genetic consequences have been well studied for populations advancing through successive short-ranged migration events. However, most populations harbor some degree of long-range dispersal, experiencing rare yet consequential migration events over arbitrarily long distances. Although dispersal is known to strongly affect spatial genetic structure during range expansions, the resulting patterns and their impact on neutral diversity remain poorly understood. Here, we systematically study the consequences of long-range dispersal on patterns of neutral variation during range expansion in a class of dispersal models which spans the extremes of local (effectively short-ranged) and global (effectively well-mixed) migration. We find that sufficiently long-ranged dispersal leaves behind a mosaic of monoallelic patches, whose number and size are highly sensitive to the distribution of dispersal distances. We develop a coarse-grained model which connects statistical features of these spatial patterns to the evolution of neutral diversity during the range expansion. We show that growth mechanisms that appear qualitatively similar can engender vastly different outcomes for diversity: Depending on the tail of the dispersal distance distribution, diversity can be either preserved (i.e., many variants survive) or lost (i.e., one variant dominates) at long times. Our results highlight the impact of spatial and migratory structure on genetic variation during processes as varied as range expansions, species invasions, epidemics, and the spread of beneficial mutations in established populations. © 2020 National Academy of Sciences. All rights reserved.
英文关键词	Long-range dispersal; Neutral genetic diversity; Range expansions
语种	英语
scopus关键词	Article; coarse grained model; controlled study; gene frequency; genetic analysis; genetic distance; genetic model; genetic variation; heterozygosity; long range dispersal; mutational analysis; population dispersal; priority journal; qualitative analysis; simulation; species invasion; allele; animal; biological model; genetic variation; heterozygote; molecular dynamics; physiology; population migration; time factor; Alleles; Animal Migration; Animals; Genetic Variation; Heterozygote; Models, Genetic; Molecular Dynamics Simulation; Time Factors
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/161005
作者单位	Paulose, J., Institute for Fundamental Science, University of Oregon, Eugene, OR 97403, United States, Department of Physics, University of Oregon, Eugene, OR 97403, United States; Hallatschek, O., Department of Physics, University of California, Berkeley, CA 94720, United States, Department of Integrative Biology, University of California, Berkeley, CA 94720, United States
推荐引用方式 GB/T 7714	Paulose J.,Hallatschek O.. The impact of long-range dispersal on gene surfing[J],2020,117(14).
APA	Paulose J.,&Hallatschek O..(2020).The impact of long-range dispersal on gene surfing.Proceedings of the National Academy of Sciences of the United States of America,117(14).
MLA	Paulose J.,et al."The impact of long-range dispersal on gene surfing".Proceedings of the National Academy of Sciences of the United States of America 117.14(2020).