气候变化领域集成服务门户(CCPortal): Fine-scale heterogeneity in Schistosoma mansoni force of infection measured through antibody response

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DOI	10.1073/pnas.2008951117
	Fine-scale heterogeneity in Schistosoma mansoni force of infection measured through antibody response
	Arnold B.F.; Kanyi H.; Njenga S.M.; Rawago F.O.; Priest J.W.; Secor W.E.; Lammie P.J.; Won K.Y.; Odiere M.R.
发表日期	2020
ISSN	0027-8424
起始页码	23174
结束页码	23181
卷号	117 期号:37
英文摘要	Schistosomiasis is among the most common parasitic diseases in the world, with over 142 million people infected in low- and middle-income countries. Measuring population-level transmission is centrally important in guiding schistosomiasis control programs. Traditionally, human Schistosoma mansoni infections have been detected using stool microscopy, which is logistically difficult at program scale and has low sensitivity when people have low infection burdens. We compared serological measures of transmission based on antibody response to S. mansoni soluble egg antigen (SEA) with stool-based measures of infection among 3,663 preschool-age children in an area endemic for S. mansoni in western Kenya. We estimated force of infection among children using the seroconversion rate and examined how it varied geographically and by age. At the community level, serological measures of transmission aligned with stool-based measures of infection (ρ = 0.94), and serological measures provided more resolution for between-community differences at lower levels of infection. Force of infection showed a clear gradient of transmission with distance from Lake Victoria, with 94% of infections and 93% of seropositive children in communities <1.5 km from the lake. Force of infection increased through age 3 y, by which time 65% (95% CI: 53%, 75%) of children were SEA positive in high-transmission communities—2 y before they would be reached by school-based deworming programs. Our results show that serologic surveillance platforms represent an important opportunity to guide and monitor schistosomiasis control programs, and that in high-transmission settings preschool-age children represent a key population missed by school-based deworming programs. © 2020 National Academy of Sciences. All rights reserved.
英文关键词	Antibodies; Epidemiology; Infectious disease transmission; Parasitology; Schistosomiasis
语种	英语
scopus关键词	parasite antigen; praziquantel; soluble egg antigen; unclassified drug; age; antibody response; antihelminthic therapy; Article; child; community; controlled study; disease surveillance; endemic disease; feces analysis; female; geography; health program; human; infant; intermethod comparison; Kenya; lake; major clinical study; male; nonhuman; parasite control; parasite transmission; preschool child; priority journal; Schistosoma mansoni; schistosomiasis mansoni; seroconversion; serology; animal; antibody production; feces; immunology; parasitology; prevalence; randomized controlled trial; Schistosoma mansoni; schistosomiasis; schistosomiasis mansoni; Animals; Antibody Formation; Child, Preschool; Feces; Female; Humans; Infant; Kenya; Male; Prevalence; Schistosoma mansoni; Schistosomiasis; Schistosomiasis mansoni
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/160809
作者单位	Arnold, B.F., Francis I. Proctor Foundation, University of California, San Francisco, CA 94143, United States, Department of Ophthalmology, University of California, San Francisco, CA 94143, United States; Kanyi, H., Eastern and Southern Africa Centre of International Parasite Control, Kenya Medical Research Institute, Nairobi, Kenya; Njenga, S.M., Eastern and Southern Africa Centre of International Parasite Control, Kenya Medical Research Institute, Nairobi, Kenya; Rawago, F.O., Center for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya; Priest, J.W., Division of Foodborne, Waterborne and Environmental Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, United States; Secor, W.E., Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, GA 30333, United States; Lammie, P.J., Neglected Tropical Disease Support Center, Task Force for Global Health, Decatur, GA 30030, United States; Won, K.Y., Division of Parasitic Dis...
推荐引用方式 GB/T 7714	Arnold B.F.,Kanyi H.,Njenga S.M.,et al. Fine-scale heterogeneity in Schistosoma mansoni force of infection measured through antibody response[J],2020,117(37).
APA	Arnold B.F..,Kanyi H..,Njenga S.M..,Rawago F.O..,Priest J.W..,...&Odiere M.R..(2020).Fine-scale heterogeneity in Schistosoma mansoni force of infection measured through antibody response.Proceedings of the National Academy of Sciences of the United States of America,117(37).
MLA	Arnold B.F.,et al."Fine-scale heterogeneity in Schistosoma mansoni force of infection measured through antibody response".Proceedings of the National Academy of Sciences of the United States of America 117.37(2020).