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DOI | 10.1073/pnas.1621359114 |
Hippo signaling promotes JNK-dependent cell migration | |
Ma X.; Wang H.; Ji J.; Xu W.; Sun Y.; Li W.; Zhang X.; Chen J.; Xue L. | |
发表日期 | 2017 |
ISSN | 0027-8424 |
起始页码 | 1934 |
结束页码 | 1939 |
卷号 | 114期号:8 |
英文摘要 | Overwhelming studies show that dysregulation of the Hippo pathway is positively correlated with cell proliferation, growth, and tumorigenesis. Paradoxically, the detailed molecular roles of the Hippo pathway in cell invasion remain debatable. Using a Drosophila invasion model in wing epithelium, we show herein that activated Hippo signaling promotes cell invasion and epithelial-mesenchymal transition through JNK, as inhibition of JNK signaling dramatically blocked Hippo pathway activation-induced matrix metalloproteinase 1 expression and cell invasion. Furthermore, we identify bantam-Rox8 modules as essential components downstream of Yorkie in mediating JNK-dependent cell invasion. Finally, we confirm that YAP (Yes-associated protein) expression negatively regulates TIA1 (Rox8 ortholog) expression and cell invasion in human cancer cells. Together, these findings provide molecular insights into Hippo pathway-mediated cell invasion and also raise a noteworthy concern in therapeutic interventions of Hippo-related cancers, as simply inhibiting Yorkie or YAP activity might paradoxically accelerate cell invasion and metastasis. © 2017, National Academy of Sciences. All rights reserved. |
英文关键词 | Drosophila; Hippo; JNK; Migration; Rox8 |
语种 | 英语 |
scopus关键词 | interstitial collagenase; protein; stress activated protein kinase; unclassified drug; Yes associated protein; bantam microRNA, Drosophila; Drosophila protein; hpo protein, Drosophila; microRNA; nuclear protein; nucleolysin TIA 1 isoform p40; phosphoprotein; protein serine threonine kinase; RNA binding protein; Rox8 protein, Drosophila; signal peptide; signal transducing adaptor protein; small interfering RNA; stress activated protein kinase; TIA1 protein, human; transactivator protein; YAP1 (Yes-associated) protein, human; Yorkie protein, Drosophila; animal cell; animal tissue; Article; cell invasion; cell migration; controlled study; Drosophila; epithelial mesenchymal transition; epithelium; human; human cell; lung cancer cell line; metastasis; nonhuman; priority journal; protein expression; animal; apoptosis; carcinogenesis; cell motion; cell proliferation; disease model; Drosophila melanogaster; fluorescence microscopy; gene expression regulation; gene knockdown; genetics; metabolism; neoplasm; pathology; RNA interference; signal transduction; tissue microarray; tumor cell line; tumor invasion; Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Carcinogenesis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Models, Animal; Drosophila melanogaster; Drosophila Proteins; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Matrix Metalloproteinase 1; MicroRNAs; Microscopy, Fluorescence; Neoplasm Invasiveness; Neoplasms; Nuclear Proteins; Phosphoproteins; Protein-Serine-Threonine Kinases; RNA Interference; RNA, Small Interfering; RNA-Binding Proteins; Signal Transduction; T-Cell Intracellular Antigen-1; Tissue Array Analysis; Trans-Activators |
来源期刊 | Proceedings of the National Academy of Sciences of the United States of America
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文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/160663 |
作者单位 | Ma, X., Institute of Intervention Vessel, Shanghai 10th People's Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Science and Technology, Tongji University, Shanghai, 200092, China, Department of Genetics, Yale School of Medicine, New Haven, CT 06536, United States, Howard Hughes Medical Institute, Yale School of Medicine, New Haven, CT 06536, United States; Wang, H., Department of Neurosurgery, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, 200003, China; Ji, J., Radiology Department, Interventional Radiology Center, Fifth Affiliated Hospital, Wenzhou Medical University, Lishui, Zhejiang 323000, China; Xu, W., Institute of Intervention Vessel, Shanghai 10th People's Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Science and Technology, Tongji University, Shanghai, 200092, China; Sun, Y., Institute of Intervention Vessel, Shanghai 10th People's Hospital, Shanghai Key Laboratory of Signaling and Disease ... |
推荐引用方式 GB/T 7714 | Ma X.,Wang H.,Ji J.,et al. Hippo signaling promotes JNK-dependent cell migration[J],2017,114(8). |
APA | Ma X..,Wang H..,Ji J..,Xu W..,Sun Y..,...&Xue L..(2017).Hippo signaling promotes JNK-dependent cell migration.Proceedings of the National Academy of Sciences of the United States of America,114(8). |
MLA | Ma X.,et al."Hippo signaling promotes JNK-dependent cell migration".Proceedings of the National Academy of Sciences of the United States of America 114.8(2017). |
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