气候变化领域集成服务门户(CCPortal): Phosphorylation and negative regulation of CONSTITUTIVELY PHOTOMORPHOGENIC 1 by PINOID in Arabidopsis

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DOI	10.1073/pnas.1702984114
	Phosphorylation and negative regulation of CONSTITUTIVELY PHOTOMORPHOGENIC 1 by PINOID in Arabidopsis
	Lin F.; Xu D.; Jiang Y.; Chen H.; Fan L.; Holm M.; Deng X.W.
发表日期	2017
ISSN	0027-8424
起始页码	6617
结束页码	6622
卷号	114 期号:25
英文摘要	CONSTITUTIVELY PHOTOMORPHOGENIC 1 (COP1) plays crucial roles in various cellular processes via its E3 ubiquitin ligase activity in organisms, ranging from fungi to humans. As a key component in regulating various biological events, COP1 itself is precisely controlled at multiple layers. Here, we report a negative regulator of COP1, PINOID (PID), which positively mediates photomorphogenic development. Specifically, PID genetically and physically interacts with COP1 and directly phosphorylates COP1 at Ser20. As a result, this posttranslational modification serves to repress COP1 activity and promote photomorphogenesis. Our findings signify a key regulatory mechanism for precisely maintaining COP1 activity, thereby ensuring appropriate development in plants.
英文关键词	Arabidopsis; COP1; Phosphorylation; Photomorphogenesis; PID
语种	英语
scopus关键词	constitutively photomorphogenic 1 protein; plant protein; unclassified drug; Arabidopsis protein; COP1 protein, Arabidopsis; PINOID protein, Arabidopsis; protein binding; protein serine threonine kinase; ubiquitin protein ligase; adult; Arabidopsis; Article; enzyme activity; Escherichia coli; gene interaction; hypocotyl; in vitro study; nonhuman; phenotype; photomorphogenesis; plant development; priority journal; protein degradation; protein expression; protein phosphorylation; protein processing; protein protein interaction; regulatory mechanism; start codon; stop codon; Arabidopsis; gene expression regulation; light; metabolism; phosphorylation; physiology; ubiquitination; Arabidopsis; Arabidopsis Proteins; Gene Expression Regulation, Plant; Light; Phosphorylation; Protein Binding; Protein Processing, Post-Translational; Protein-Serine-Threonine Kinases; Ubiquitin-Protein Ligases; Ubiquitination
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/160624
作者单位	Lin, F., Department of Biology, Southern University of Science and Technology, Shenzhen, 518055, China, State Key Laboratory of Protein and Plant Gene Research, Peking-Tsinghua Center for Life Sciences, School of Advanced Agriculture Sciences, School of Life Sciences, Peking University, Beijing, 100871, China; Xu, D., Department of Biology, Southern University of Science and Technology, Shenzhen, 518055, China; Jiang, Y., Department of Biology, Southern University of Science and Technology, Shenzhen, 518055, China, State Key Laboratory of Protein and Plant Gene Research, Peking-Tsinghua Center for Life Sciences, School of Advanced Agriculture Sciences, School of Life Sciences, Peking University, Beijing, 100871, China; Chen, H., State Key Laboratory of Protein and Plant Gene Research, Peking-Tsinghua Center for Life Sciences, School of Advanced Agriculture Sciences, School of Life Sciences, Peking University, Beijing, 100871, China; Fan, L., State Key Laboratory of Protein and Plant Gene Research, Peking-...
推荐引用方式 GB/T 7714	Lin F.,Xu D.,Jiang Y.,et al. Phosphorylation and negative regulation of CONSTITUTIVELY PHOTOMORPHOGENIC 1 by PINOID in Arabidopsis[J],2017,114(25).
APA	Lin F..,Xu D..,Jiang Y..,Chen H..,Fan L..,...&Deng X.W..(2017).Phosphorylation and negative regulation of CONSTITUTIVELY PHOTOMORPHOGENIC 1 by PINOID in Arabidopsis.Proceedings of the National Academy of Sciences of the United States of America,114(25).
MLA	Lin F.,et al."Phosphorylation and negative regulation of CONSTITUTIVELY PHOTOMORPHOGENIC 1 by PINOID in Arabidopsis".Proceedings of the National Academy of Sciences of the United States of America 114.25(2017).