气候变化领域集成服务门户(CCPortal): Framework for gradual progression of cell ontogeny in the Arabidopsis root meristem

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DOI	10.1073/pnas.1707400114
	Framework for gradual progression of cell ontogeny in the Arabidopsis root meristem
	Wendrich J.R.; Möller B.K.; Li S.; Saiga S.; Sozzani R.; Benfey P.N.; De Rybel B.; Weijers D.
发表日期	2017
ISSN	0027-8424
起始页码	E8922
结束页码	E8929
卷号	114 期号:42
英文摘要	In plants, apical meristems allow continuous growth along the body axis. Within the root apical meristem, a group of slowly dividing quiescent center cells is thought to limit stem cell activity to directly neighboring cells, thus endowing them with unique properties, distinct from displaced daughters. This binary identity of the stem cells stands in apparent contradiction to the more gradual changes in cell division potential and differentiation that occur as cells move further away from the quiescent center. To address this paradox and to infer molecular organization of the root meristem, we used a whole-genome approach to determine dominant transcriptional patterns along root ontogeny zones. We found that the prevalent patterns are expressed in two opposing gradients. One is characterized by genes associated with development, the other enriched in differentiation genes. We confirmed these transcript gradients, and demonstrate that these translate to gradients in protein accumulation and gradual changes in cellular properties. We also show that gradients are genetically controlled through multiple pathways. Based on these findings, we propose that cells in the Arabidopsis root meristem gradually transition from stem cell activity toward differentiation. © 2017, National Academy of Sciences. All rights reserved.
英文关键词	Arabidopsis; Plant development; Root meristem; Transcriptional regulation
语种	英语
scopus关键词	cycline; histidine phosphotransfer protein 6; lonely guy3; protein; protein tmo5; unclassified drug; Arabidopsis protein; green fluorescent protein; apical meristem; Arabidopsis; Article; cell differentiation; cell division; cell population; controlled study; gene expression; genetic transcription; nonhuman; nucleotide sequence; ontogeny; priority journal; root apical meristem; stem cell; cytology; flow cytometry; gene expression regulation; genetics; growth, development and aging; meristem; plant cell; plant root; procedures; transgenic plant; Arabidopsis; Arabidopsis Proteins; Flow Cytometry; Gene Expression Regulation, Plant; Green Fluorescent Proteins; Meristem; Plant Cells; Plant Roots; Plants, Genetically Modified
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/160586
作者单位	Wendrich, J.R., Laboratory of Biochemistry, Wageningen University, Wageningen, 6708 WE, Netherlands, Department of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, 9052, Belgium, Vlaams Instituut voor Biotechnologie, Center for Plant Systems Biology, Ghent, 9052, Belgium; Möller, B.K., Laboratory of Biochemistry, Wageningen University, Wageningen, 6708 WE, Netherlands, Department of Plant Biotechnology and Bioinformatics, Vlaams Instituut voor Biotechnologie Center for Plant Systems Biology, Ghent University, Ghent, 9052, Belgium; Li, S., Department of Biology, Duke University, Durham, NC 27708, United States, Howard Hughes Medical Institute, Duke University, Durham, NC 27708, United States, Department of Crop and Soil Environmental Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, United States; Saiga, S., Laboratory of Biochemistry, Wageningen University, Wageningen, 6708 WE, Netherlands; Sozzani, R., Department of Biology, Duke University, Durham, N...
推荐引用方式 GB/T 7714	Wendrich J.R.,Möller B.K.,Li S.,et al. Framework for gradual progression of cell ontogeny in the Arabidopsis root meristem[J],2017,114(42).
APA	Wendrich J.R..,Möller B.K..,Li S..,Saiga S..,Sozzani R..,...&Weijers D..(2017).Framework for gradual progression of cell ontogeny in the Arabidopsis root meristem.Proceedings of the National Academy of Sciences of the United States of America,114(42).
MLA	Wendrich J.R.,et al."Framework for gradual progression of cell ontogeny in the Arabidopsis root meristem".Proceedings of the National Academy of Sciences of the United States of America 114.42(2017).