气候变化领域集成服务门户(CCPortal): Physics of lumen growth

CCPortal

DOI	10.1073/pnas.1722154115
	Physics of lumen growth
	Dasgupta S.; Gupta K.; Zhang Y.; Viasnoff V.; Prost J.
发表日期	2018
ISSN	0027-8424
起始页码	E4751
结束页码	E4757
卷号	115 期号:21
英文摘要	We model the dynamics of formation of intercellular secretory lumens. Using conservation laws, we quantitatively study the balance between paracellular leaks and the build-up of osmotic pressure in the lumen. Our model predicts a critical pumping threshold to expand stable lumens. Consistently with experimental observations in bile canaliculi, the model also describes a transition between a monotonous and oscillatory regime during luminogenesis as a function of ion and water transport parameters. We finally discuss the possible importance of regulation of paracellular leaks in intercellular tubulogenesis. © 2018 National Academy of Sciences. All Rights Reserved.
英文关键词	Lumenogenesis; morphogenesis; osmotic pressure
语种	英语
scopus关键词	ion; Article; growth; hydrostatic pressure; intercellular space; ion transport; lumen; mechanics; molecular model; physics; priority journal; steady state; volume; animal; cell culture; cell junction; chemistry; cytology; liver cell; osmosis; physiology; rat; theoretical model; Animals; Cells, Cultured; Hepatocytes; Intercellular Junctions; Models, Theoretical; Osmosis; Rats
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/160510
作者单位	Dasgupta, S., Mechanobiology Institute, National University of Singapore, Singapore, 117411, Singapore, Laboratoire Physico Chimie Curie, Institut Curie, Paris Science et Lettres Research University, CNRS UMR168, Paris, 75005, France; Gupta, K., Mechanobiology Institute, National University of Singapore, Singapore, 117411, Singapore; Zhang, Y., Mechanobiology Institute, National University of Singapore, Singapore, 117411, Singapore; Viasnoff, V., Mechanobiology Institute, National University of Singapore, Singapore, 117411, Singapore, CNRS Biomechanics of Cell Contacts, Singapore, 117411, Singapore, Department of Biological Sciences, National University of Singapore, Singapore, 117411, Singapore; Prost, J., Mechanobiology Institute, National University of Singapore, Singapore, 117411, Singapore, Laboratoire Physico Chimie Curie, Institut Curie, Paris Science et Lettres Research University, CNRS UMR168, Paris, 75005, France
推荐引用方式 GB/T 7714	Dasgupta S.,Gupta K.,Zhang Y.,et al. Physics of lumen growth[J],2018,115(21).
APA	Dasgupta S.,Gupta K.,Zhang Y.,Viasnoff V.,&Prost J..(2018).Physics of lumen growth.Proceedings of the National Academy of Sciences of the United States of America,115(21).
MLA	Dasgupta S.,et al."Physics of lumen growth".Proceedings of the National Academy of Sciences of the United States of America 115.21(2018).