Climate Change Data Portal
DOI | 10.1073/pnas.1806900115 |
Kinetically guided radical-based synthesis of C(sp3)−C(sp3) linkages on DNA | |
Wang J.; Lundberg H.; Asai S.; Martín-Acosta P.; Chen J.S.; Brown S.; Farrell W.; Dushin R.G.; O’Donnell C.J.; Ratnayake A.S.; Richardson P.; Liu Z.; Qin T.; Blackmond D.G.; Baran P.S. | |
发表日期 | 2018 |
ISSN | 0027-8424 |
起始页码 | E6404 |
结束页码 | E6410 |
卷号 | 115期号:28 |
英文摘要 | DNA-encoded libraries (DEL)-based discovery platforms have re cently been widely adopted in the pharmaceutical industry, mainl due to their powerful diversity and incredible number of mole cules. In the two decades since their disclosure, great strides hav been made to expand the toolbox of reaction modes that are com patible with the idiosyncratic aqueous, dilute, and DNA-sensitiv parameters of this system. However, construction of highly impor tant C(sp3)−C(sp3) linkages on DNA through cross-coupling remain unexplored. In this article, we describe a systematic approach t translating standard organic reactions to a DEL setting throug the tactical combination of kinetic analysis and empirical screenin with information captured from data mining. To exemplify thi model, implementation of the Giese addition to forge high valu C–C bonds on DNA was studied, which represents a radical-base synthesis in DEL. © 2018 National Academy of Sciences. All rights reserved. |
英文关键词 | Combinatorial chemistr; DNA-encoded libraries; Kinetic analysis; Organic synthesis; Radical reactions |
语种 | 英语 |
scopus关键词 | DNA; transcription factor Sp3; DNA; Article; chemical bond; chemical structure; combinatorial chemistry; DNA cross linking; DNA library; genetic transcription and translation; genetic variability; kinetics; priority journal; radical reaction; synthesis; chemistry; gene library; molecular model; DNA; Gene Library; Kinetics; Models, Molecular |
来源期刊 | Proceedings of the National Academy of Sciences of the United States of America |
文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/160498 |
作者单位 | Wang, J., Department of Chemistry, Scripps Research Institute, La Jolla, CA 92037, United States; Lundberg, H., Department of Chemistry, Scripps Research Institute, La Jolla, CA 92037, United States; Asai, S., Department of Chemistry, Scripps Research Institute, La Jolla, CA 92037, United States; Martín-Acosta, P., Department of Chemistry, Scripps Research Institute, La Jolla, CA 92037, United States; Chen, J.S., Department of Chemistry, Scripps Research Institute, La Jolla, CA 92037, United States; Brown, S., Natural Products Laboratory, Worldwide Medicinal Chemistry, Pfizer Worldwide Research and Development, Groton, CT 06340, United States; Farrell, W., Department of Chemistry, La Jolla Laboratories, Pfizer Inc., San Diego, CA 92121, United States; Dushin, R.G., Natural Products Laboratory, Worldwide Medicinal Chemistry, Pfizer Worldwide Research and Development, Groton, CT 06340, United States; O’Donnell, C.J., Natural Products Laboratory, Worldwide Medicinal Chemistry, Pfizer Worldwide Resear... |
推荐引用方式 GB/T 7714 | Wang J.,Lundberg H.,Asai S.,et al. Kinetically guided radical-based synthesis of C(sp3)−C(sp3) linkages on DNA[J],2018,115(28). |
APA | Wang J..,Lundberg H..,Asai S..,Martín-Acosta P..,Chen J.S..,...&Baran P.S..(2018).Kinetically guided radical-based synthesis of C(sp3)−C(sp3) linkages on DNA.Proceedings of the National Academy of Sciences of the United States of America,115(28). |
MLA | Wang J.,et al."Kinetically guided radical-based synthesis of C(sp3)−C(sp3) linkages on DNA".Proceedings of the National Academy of Sciences of the United States of America 115.28(2018). |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。