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DOI	10.1073/pnas.1805981115
	Oscillatory fluid flow drives scaling of contraction wave with system size
	Julien J.-D.; Alim K.
发表日期	2018
ISSN	0027-8424
起始页码	10612
结束页码	10617
卷号	115 期号:42
英文摘要	Flows over remarkably long distances are crucial to the functioning of many organisms, across all kingdoms of life. Coordinated flows are fundamental to power deformations, required for migration or development, or to spread resources and signals. A ubiquitous mechanism to generate flows, particularly prominent in animals and amoebas, is actomyosin cortex-driven mechanical deformations that pump the fluid enclosed by the cortex. However, it is unclear how cortex dynamics can self-organize to give rise to coordinated flows across the largely varying scales of biological systems. Here, we develop a mechanochemical model of actomyosin cortex mechanics coupled to a contraction-triggering, soluble chemical. The chemical itself is advected with the flows generated by the cortex-driven deformations of the tubularshaped cell. The theoretical model predicts a dynamic instability giving rise to stable patterns of cortex contraction waves and oscillatory flows. Surprisingly, simulated patterns extend beyond the intrinsic length scale of the dynamic instability-scaling with system size instead. Patterns appear randomly but can be robustly generated in a growing system or by flow-generating boundary conditions. We identify oscillatory flows as the key for the scaling of contraction waves with system size. Our work shows the importance of active flows in biophysical models of patterning, not only as a regulating input or an emergent output, but also as a full part of a self-organized machinery. Contractions and fluid flows are observed in all kinds of organisms, so this concept is likely to be relevant for a broad class of systems. © 2018 National Academy of Sciences. All rights reserved.
英文关键词	active matter; fluid mechanics; pattern formation
语种	英语
scopus关键词	myosin adenosine triphosphatase; actin filament; animal; biological model; mechanotransduction; metabolism; muscle contraction; physiology; theoretical model; Actin Cytoskeleton; Actomyosin; Animals; Mechanotransduction, Cellular; Models, Biological; Models, Theoretical; Muscle Contraction
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/160455
作者单位	Julien, J.-D., Biological Physics and Morphogenesis Group, Max Planck Institute for Dynamics and Self-Organization, Göttingen, 37077, Germany; Alim, K., Biological Physics and Morphogenesis Group, Max Planck Institute for Dynamics and Self-Organization, Göttingen, 37077, Germany
推荐引用方式 GB/T 7714	Julien J.-D.,Alim K.. Oscillatory fluid flow drives scaling of contraction wave with system size[J],2018,115(42).
APA	Julien J.-D.,&Alim K..(2018).Oscillatory fluid flow drives scaling of contraction wave with system size.Proceedings of the National Academy of Sciences of the United States of America,115(42).
MLA	Julien J.-D.,et al."Oscillatory fluid flow drives scaling of contraction wave with system size".Proceedings of the National Academy of Sciences of the United States of America 115.42(2018).