气候变化领域集成服务门户(CCPortal): Ketone body receptor GPR43 regulates lipid metabolism under ketogenic conditions

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DOI	10.1073/pnas.1912573116
	Ketone body receptor GPR43 regulates lipid metabolism under ketogenic conditions
	Miyamoto J.; Ohue-Kitano R.; Mukouyama H.; Nishida A.; Watanabe K.; Igarashi M.; Irie J.; Tsujimoto G.; Satoh-Asahara N.; Itoh H.; Kimura I.
发表日期	2019
ISSN	0027-8424
起始页码	23813
结束页码	23821
卷号	116 期号:47
英文摘要	Ketone bodies, including β-hydroxybutyrate and acetoacetate, are important alternative energy sources during energy shortage. β-Hydroxybutyrate also acts as a signaling molecule via specific G protein-coupled receptors (GPCRs); however, the specific associated GPCRs and physiological functions of acetoacetate remain unknown. Here we identified acetoacetate as an endogenous agonist for short-chain fatty acid (SCFA) receptor GPR43 by ligand screening in a heterologous expression system. Under ketogenic conditions, such as starvation and low-carbohydrate diets, plasma acetoacetate levels increased markedly, whereas plasma and cecal SCFA levels decreased dramatically, along with an altered gut microbiota composition. In addition, Gpr43-deficient mice showed reduced weight loss and suppressed plasma lipoprotein lipase activity during fasting and eucaloric ketogenic diet feeding. Moreover, Gpr43-deficient mice exhibited minimal weight decrease after intermittent fasting. These observations provide insight into the role of ketone bodies in energy metabolism under shifts in nutrition and may contribute to the development of preventive medicine via diet and foods. © 2019 National Academy of Sciences. All rights reserved.
英文关键词	Fasting; FFAR2; Gut microbiota; Ketone body; Low carbohydrate
语种	英语
scopus关键词	acetoacetic acid; G protein coupled receptor; G protein coupled receptor 43; ketone body; lipoprotein lipase; unclassified drug; animal cell; animal tissue; Article; body weight loss; caloric intake; controlled study; embryo; energy metabolism; enzyme activity; enzyme blood level; fasting; fatty acid blood level; feeding; GPR43 gene; heterologous expression; intestine flora; ketogenesis; ketogenic diet; lipid analysis; lipid composition; lipid metabolism; low carbohydrate diet; mouse; nonhuman; priority journal; regulatory mechanism; starvation
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/160409
作者单位	Miyamoto, J., Department of Applied Biological Science, Graduate School of Agriculture, Tokyo University of Agriculture and Technology, Fuchu-shi, Tokyo 183-8509, Japan, Japan Agency for Medical Research and Development-Core Research for Evolutionary Medical Science and Technology (AMED-CREST), Japan Agency for Medical Research and Development, Chiyoda-ku, Tokyo 100-0004, Japan; Ohue-Kitano, R., Department of Applied Biological Science, Graduate School of Agriculture, Tokyo University of Agriculture and Technology, Fuchu-shi, Tokyo 183-8509, Japan, Japan Agency for Medical Research and Development-Core Research for Evolutionary Medical Science and Technology (AMED-CREST), Japan Agency for Medical Research and Development, Chiyoda-ku, Tokyo 100-0004, Japan, Department of Endocrinology, Metabolism, and Hypertension, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, 612-8555, Japan; Mukouyama, H., Department of Applied Biological Science, Graduate School of Agricult...
推荐引用方式 GB/T 7714	Miyamoto J.,Ohue-Kitano R.,Mukouyama H.,et al. Ketone body receptor GPR43 regulates lipid metabolism under ketogenic conditions[J],2019,116(47).
APA	Miyamoto J..,Ohue-Kitano R..,Mukouyama H..,Nishida A..,Watanabe K..,...&Kimura I..(2019).Ketone body receptor GPR43 regulates lipid metabolism under ketogenic conditions.Proceedings of the National Academy of Sciences of the United States of America,116(47).
MLA	Miyamoto J.,et al."Ketone body receptor GPR43 regulates lipid metabolism under ketogenic conditions".Proceedings of the National Academy of Sciences of the United States of America 116.47(2019).