气候变化领域集成服务门户(CCPortal): Self-organized shape dynamics of active surfaces

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DOI	10.1073/pnas.1810896115
	Self-organized shape dynamics of active surfaces
	Mietke A.; Jülicher F.; Sbalzarini I.F.
发表日期	2019
ISSN	0027-8424
起始页码	29
结束页码	34
卷号	116 期号:1
英文摘要	Mechanochemical processes in thin biological structures, such as the cellular cortex or epithelial sheets, play a key role during the morphogenesis of cells and tissues. In particular, they are responsible for the dynamical organization of active stresses that lead to flows and deformations of the material. Consequently, advective transport redistributes force-generating molecules and thereby contributes to a complex mechanochemical feedback loop. It has been shown in fixed geometries that this mechanism enables patterning, but the interplay of these processes with shape changes of the material remains to be explored. In this work, we study the fully self-organized shape dynamics using the theory of active fluids on deforming surfaces and develop a numerical approach to solve the corresponding force and torque balance equations. We describe the spontaneous generation of nontrivial surface shapes, shape oscillations, and directed surface flows that resemble peristaltic waves from self-organized, mechanochemical processes on the deforming surface. Our approach provides opportunities to explore the dynamics of self-organized active surfaces and can help to understand the role of shape as an integral element of the mechanochemical organization of morphogenetic processes. © 2019 National Academy of Sciences. All Rights Reserved.
英文关键词	Active fluids; Morphogenesis; Self-organization; Surface mechanics
语种	英语
scopus关键词	article; geometry; morphogenesis; oscillation; peristalsis; theoretical study; torque; animal; biological model; biomechanics; mathematics; physiology; surface property; Animals; Biomechanical Phenomena; Mathematics; Models, Biological; Morphogenesis; Surface Properties; Torque
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/160387
作者单位	Mietke, A., Max Planck Institute for the Physics of Complex Systems, Dresden, 01187, Germany, Chair of Scientific Computing for Systems Biology, Faculty of Computer Science, Technische Universität, Dresden, Dresden, 01187, Germany, Center for Systems Biology Dresden, Dresden, 01307, Germany, MOSAIC Group, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, 01307, Germany; Jülicher, F., Max Planck Institute for the Physics of Complex Systems, Dresden, 01187, Germany, Center for Systems Biology Dresden, Dresden, 01307, Germany; Sbalzarini, I.F., Chair of Scientific Computing for Systems Biology, Faculty of Computer Science, Technische Universität, Dresden, Dresden, 01187, Germany, Center for Systems Biology Dresden, Dresden, 01307, Germany, MOSAIC Group, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, 01307, Germany
推荐引用方式 GB/T 7714	Mietke A.,Jülicher F.,Sbalzarini I.F.. Self-organized shape dynamics of active surfaces[J],2019,116(1).
APA	Mietke A.,Jülicher F.,&Sbalzarini I.F..(2019).Self-organized shape dynamics of active surfaces.Proceedings of the National Academy of Sciences of the United States of America,116(1).
MLA	Mietke A.,et al."Self-organized shape dynamics of active surfaces".Proceedings of the National Academy of Sciences of the United States of America 116.1(2019).