气候变化领域集成服务门户(CCPortal): Modulation of tissue growth heterogeneity by responses to mechanical stress

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DOI	10.1073/pnas.1815342116
	Modulation of tissue growth heterogeneity by responses to mechanical stress
	Fruleux A.; Boudaoud A.
发表日期	2019
ISSN	0027-8424
起始页码	1940
结束页码	1945
卷号	116 期号:6
英文摘要	Morphogenesis often yields organs with robust size and shapes, whereas cell growth and deformation feature significant spatiotemporal variability. Here, we investigate whether tissue responses to mechanical signals contribute to resolve this apparent paradox. We built a model of growing tissue made of fiber-like material, which may account for the cytoskeleton, polar cell-cell adhesion, or the extracellular matrix in animals and for the cell wall in plants. We considered the synthesis and remodeling of this material, as well as the modulation of synthesis by isotropic and anisotropic response to mechanical stress. Formally, our model describes an expanding, mechanoresponsive, nematic, and active fluid. We show that mechanical responses buffer localized perturbations, with two possible regimes-hyporesponsive and hyperresponsive-and the transition between the two corresponds to a minimum value of the relaxation time. Whereas robustness of shapes suggests that growth fluctuations are confined to small scales, our model yields growth fluctuations that have long-range correlations. This indicates that growth fluctuations are a significant source of heterogeneity in development. Nevertheless, we find that mechanical responses may dampen such fluctuations, with a specific magnitude of anisotropic response that minimizes heterogeneity of tissue contours. We finally discuss how our predictions might apply to the development of plants and animals. Altogether, our results call for the systematic quantification of fluctuations in growing tissues. © 2019 National Academy of Sciences. All Rights Reserved.
英文关键词	Active fluid; Growth variability; Mechanical signals; Morphogenesis; Robustness
语种	英语
scopus关键词	buffer; anisotropy; Article; biological model; biosynthesis; cell adhesion; cell growth; cell heterogeneity; cell maturation; cellular stress response; cytoskeleton; extracellular matrix; mechanical stress; plant development; prediction; priority journal; tissue growth; animal; biological model; biomechanics; cell enlargement; cell size; cell wall; morphogenesis; organ size; plant; Animals; Anisotropy; Biomechanical Phenomena; Cell Adhesion; Cell Enlargement; Cell Size; Cell Wall; Cytoskeleton; Extracellular Matrix; Models, Biological; Morphogenesis; Organ Size; Plants; Stress, Mechanical
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/160380
作者单位	Fruleux, A., Reproduction et Développement des Plantes, Université de Lyon, École normale supérieure de Lyon, Université Claude Bernard Lyon 1, Institut National de la Recherche Agronomique, CNRS, Lyon Cedex 07, 69364, France; Boudaoud, A., Reproduction et Développement des Plantes, Université de Lyon, École normale supérieure de Lyon, Université Claude Bernard Lyon 1, Institut National de la Recherche Agronomique, CNRS, Lyon Cedex 07, 69364, France
推荐引用方式 GB/T 7714	Fruleux A.,Boudaoud A.. Modulation of tissue growth heterogeneity by responses to mechanical stress[J],2019,116(6).
APA	Fruleux A.,&Boudaoud A..(2019).Modulation of tissue growth heterogeneity by responses to mechanical stress.Proceedings of the National Academy of Sciences of the United States of America,116(6).
MLA	Fruleux A.,et al."Modulation of tissue growth heterogeneity by responses to mechanical stress".Proceedings of the National Academy of Sciences of the United States of America 116.6(2019).