气候变化领域集成服务门户(CCPortal): The UBC27–AIRP3 ubiquitination complex modulates ABA signaling by promoting the degradation of ABI1 in Arabidopsis

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DOI	10.1073/pnas.2007366117
	The UBC27–AIRP3 ubiquitination complex modulates ABA signaling by promoting the degradation of ABI1 in Arabidopsis
	Pan W.; Lin B.; Yang X.; Liu L.; Xia R.; Li J.; Wu Y.; Xie Q.
发表日期	2020
ISSN	0027-8424
起始页码	27694
结束页码	27702
卷号	117 期号:44
英文摘要	Abscisic acid (ABA) is the key phytohormone in plant drought tolerance and stress adaptation. The clade A protein phosphatase 2Cs (PP2Cs) like ABI1 (ABA-INSENSITIVE 1) work as coreceptors of ABA and regulate multiple ABA responses. Ubiquitination of ABI1 has been proven to play important regulatory roles in ABA signaling. However, the specific ubiquitin conjugating enzyme (E2) involved is unknown. Here, we report that UBC27 is an active E2 that positively regulates ABA signaling and drought tolerance. UBC27 forms the E2-E3 pair with the drought regulator RING E3 ligase AIRP3. Both UBC27 and AIRP3 interact with ABI1 and affect the ubiquitination and degradation of ABI1. ABA activates the expression of UBC27, inhibits the proteasome degradation of UBC27, and enhances the interaction between UBC27 and ABI1 to increase its activity. These findings uncover a regulatory mechanism in ABA signaling and drought response and provide a further understanding of the plant ubiquitination system and ABA signaling pathway. © 2020 National Academy of Sciences. All rights reserved.
英文关键词	ABA; ABI1; Drought response; Ubiquitin conjugating enzyme; Ubiquitination
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/160201
作者单位	Pan, W., State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Innovative Academy of Seed Design, Chinese Academy of Sciences, Beijing, 100101, China, College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China; Lin, B., State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Innovative Academy of Seed Design, Chinese Academy of Sciences, Beijing, 100101, China, College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China; Yang, X., State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Innovative Academy of Seed Design, Chinese Academy of Sciences, Beijing, 100101, China; Liu, L., School of Life Sciences, Shandong University, Qingdao, Shandong 266237, China; Xia, R., State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Innovative Academy of Seed Design, Chinese Academy of ...
推荐引用方式 GB/T 7714	Pan W.,Lin B.,Yang X.,等. The UBC27–AIRP3 ubiquitination complex modulates ABA signaling by promoting the degradation of ABI1 in Arabidopsis[J],2020,117(44).
APA	Pan W..,Lin B..,Yang X..,Liu L..,Xia R..,...&Xie Q..(2020).The UBC27–AIRP3 ubiquitination complex modulates ABA signaling by promoting the degradation of ABI1 in Arabidopsis.Proceedings of the National Academy of Sciences of the United States of America,117(44).
MLA	Pan W.,et al."The UBC27–AIRP3 ubiquitination complex modulates ABA signaling by promoting the degradation of ABI1 in Arabidopsis".Proceedings of the National Academy of Sciences of the United States of America 117.44(2020).