气候变化领域集成服务门户(CCPortal): Inihibition of mullet (M. liza) brain acetylcholinesterase activity by in vitro polycyclic aromatic hydrocarbon exposure

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DOI	10.1016/j.marpolbul.2019.01.027
	Inihibition of mullet (M. liza) brain acetylcholinesterase activity by in vitro polycyclic aromatic hydrocarbon exposure
	Hauser-Davis R.A.; Lopes R.M.; Ziolli R.L.
发表日期	2019
ISSN	0025326X
起始页码	30
结束页码	34
卷号	140
英文摘要	Polycyclic aromatic hydrocarbons (PAH) have been reported as acetylcholinesterase (AChE) inibitors, although in vitro studies on PAH effects on AChE activity are scarce and have only been performed using electric eel brain extracts. Thus, this study investigated PAH effects on brain AChE activity in a tropical fish species in Southeastern Brazil, mullet (Mugil liza). Mullet specimens were obtained from Guanabara Bay (N = 20), Rio de Janeiro, Brazil. Brain AChE was extracted and exposed to an environmentally relevant concentration of Pyrene, Chrysene, Phenanthrene, and Naphthalene, and PAH metabolites, 2-Naphthol and 1-OH-Pyrene. AChE activity inhibition was observed, although no difference was observed between high- and low- molecular weight PAH. 2-Naphthol was a less potent AChE inhibitor than Naphthalene, albeit non-significantly. Further studies are required, since only one PAH concentration was used herein. Mullet brain extracts seem to be adequate to assess possible neurotoxic PAH effects on fish AChE. © 2019 Elsevier Ltd
英文关键词	AChE; Biomarker; In vitro assay; Mugil liza; PAH
语种	英语
scopus关键词	Biomarkers; Brain; Fish; Hydrocarbons; Mineral oils; Naphthalene; Naphthol; Acetylcholinesterase; Acetylcholinesterase activity; AChE; In-vitro assays; Low molecular weight; Mugil liza; Polycyclic aromatic hydrocarbon (PAH); Southeastern Brazil; Polycyclic aromatic hydrocarbons; 1 hydroxypyrene; 2 naphthol; acetylcholinesterase; chrysene; naphthalene; phenanthrene; polycyclic aromatic hydrocarbon; pyrene; acetylcholinesterase; cholinesterase inhibitor; fish protein; polycyclic aromatic hydrocarbon; biomarker; concentration (composition); enzyme; finfish; inhibition; metabolite; neurology; PAH; animal tissue; Article; brain; Brazil; controlled study; environmental exposure; enzyme activity; enzyme inhibition; in vitro study; molecular weight; Mugil; Mugil liza; nonhuman; animal; antagonists and inhibitors; brain; drug effect; ecotoxicology; enzymology; metabolism; procedures; Smegmamorpha; toxicity; tropic climate; water pollutant; Brazil; Guanabara Bay; Rio de Janeiro [Brazil]; Electrophorus electricus; Mugil liza; Acetylcholinesterase; Animals; Brain; Brazil; Cholinesterase Inhibitors; Ecotoxicology; Environmental Exposure; Fish Proteins; Polycyclic Aromatic Hydrocarbons; Smegmamorpha; Tropical Climate; Water Pollutants, Chemical
来源期刊	Marine Pollution Bulletin
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/150120
作者单位	Centro de Estudos da Saúde do Trabalhador e Ecologia Humana, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil; Laboratório de Comunicação Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil; Universidade Federal do Estado do Rio de Janeiro, UNIRIO, Rio de Janeiro, RJ, Brazil
推荐引用方式 GB/T 7714	Hauser-Davis R.A.,Lopes R.M.,Ziolli R.L.. Inihibition of mullet (M. liza) brain acetylcholinesterase activity by in vitro polycyclic aromatic hydrocarbon exposure[J],2019,140.
APA	Hauser-Davis R.A.,Lopes R.M.,&Ziolli R.L..(2019).Inihibition of mullet (M. liza) brain acetylcholinesterase activity by in vitro polycyclic aromatic hydrocarbon exposure.Marine Pollution Bulletin,140.
MLA	Hauser-Davis R.A.,et al."Inihibition of mullet (M. liza) brain acetylcholinesterase activity by in vitro polycyclic aromatic hydrocarbon exposure".Marine Pollution Bulletin 140(2019).