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DOI	10.1016/j.marpolbul.2020.111375
	Ecotoxic response of nematodes to ivermectin; a potential anti-COVID-19 drug treatment
	Essid N.; Allouche M.; Lazzem M.; Harrath A.H.; Mansour L.; Alwasel S.; Mahmoudi E.; Beyrem H.; Boufahja F.
发表日期	2020
ISSN	0025326X
卷号	157
英文摘要	At the end of March 2020, ivermectin was confirmed as a drug for COVID-19 treatment. A significant amount of ivermectin could deposit into sediments of the semi-closed Mediterranean Sea, where three European COVID-19 epicenters are located: Italy, Spain, and France. Meiobenthic nematodes were exposed to three ivermectin doses (1.8 ng.g−1, 9 ng.g−1, and 18 ng.g−1) for 10 days. Ivermectin caused a great reduction in abundance. However, the diversity indices decreased only at high doses. Ivermectin disadvantaged the 1B-Cr-Id functional type (non-selective deposit feeders and nematodes with circular or indistinct amphids) and benefited the 2A-REL-Sp type (epistrate feeders and nematodes with rounded or elongated loop amphids). Thus, Trophic Diversity and Amphideal Diversity index values increased with sedimentary ivermectin enrichment. Large amphideal foveas were more efficient for 2A-REL-Sp nematodes to avoid ivermectin. The responses of the functional type 2A-REL-Sp and corresponding taxa predict post-COVID-19 environmental concerns and the bioaccumulation of ivermectin in seafoods. © 2020 Elsevier Ltd
英文关键词	COVID-19; Ecotoxicity; Ivermectin; Meiobenthic nematodes
语种	英语
scopus关键词	Biochemistry; Deposits; Deposit feeder; Diversity index; Environmental concerns; Exposed to; Functional types; High dose; Ivermectin; Mediterranean sea; Drug therapy; ivermectin; ivermectin; abundance; bioaccumulation; diversity index; ecotoxicology; ivermectin; marine sediment; nematode; pollution effect; seafood; antiviral therapy; Article; bioaccumulation; controlled study; coronavirus disease 2019; drug contamination; drug effect; ecotoxicity; France; Italy; nematode; nonhuman; population abundance; Spain; species diversity; taxonomy; animal; Betacoronavirus; Coronavirus infection; human; Mediterranean Sea; nematode; pandemic; virus pneumonia; Mediterranean Sea; Nematoda; Animals; Betacoronavirus; Coronavirus Infections; France; Humans; Italy; Ivermectin; Mediterranean Sea; Nematoda; Pandemics; Pneumonia, Viral; Spain
来源期刊	Marine Pollution Bulletin
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/148815
作者单位	University of Carthage, Faculty of Sciences of Bizerte, Laboratory of Environment Biomonitoring, Coastal Ecology and Ecotoxicology Unit, Zarzouna, 7021, Tunisia; King Saud University, Zoology Department, College of Science, Box 2455, Riyadh, 11451, Saudi Arabia
推荐引用方式 GB/T 7714	Essid N.,Allouche M.,Lazzem M.,et al. Ecotoxic response of nematodes to ivermectin; a potential anti-COVID-19 drug treatment[J],2020,157.
APA	Essid N..,Allouche M..,Lazzem M..,Harrath A.H..,Mansour L..,...&Boufahja F..(2020).Ecotoxic response of nematodes to ivermectin; a potential anti-COVID-19 drug treatment.Marine Pollution Bulletin,157.
MLA	Essid N.,et al."Ecotoxic response of nematodes to ivermectin; a potential anti-COVID-19 drug treatment".Marine Pollution Bulletin 157(2020).