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DOI	10.1016/j.marpolbul.2020.111493
	Ecotoxicological assessment of chemotherapeutic agents using toxicity tests with embryos of Mellita quinquiesperforata
	Mello L.C.; da Fonseca T.G.; Denis Moledode de Souza A.
发表日期	2020
ISSN	0025326X
卷号	159
英文摘要	The consumption of anticancer agents has increased in the recent decades, and these substances may be present in sewage. Consequently, they may reach the environment when sanitation infrastructure is ineffective. This study evaluated the toxicity of three anticancer agents—Tamoxifen (TAM), Cisplatin (CisPt), and Cyclophosphamide (CP)—on the development of embryos of the sand-dollar Mellita quinquiesperforata. Adult individuals were collected in sandy beaches, and gametes were obtained. Freshly-fertilized eggs were exposed to increasing sets of concentrations of each compound, and the effective concentrations needed to cause a 50% effect in the organisms (EC50) were calculated. The three compounds were toxic, and their EC50 values were 16.78 ± 2.42 ng·L−1 (TAM), 27.20 ± 38.26 ng·L−1 (CisPt), and 101.82 ± 70.96 ng·L−1 (CP). There is no information on the environmental levels of these compounds in Brazil, but as they were already detected in ng·L−1 levels worldwide, it can be expected that these substances pose environmental risks to the marine biota. © 2020 Elsevier Ltd
英文关键词	Chemotherapeutics; Echinoderms; Ecotoxicity; Marine pollution; Pharmaceuticals
语种	英语
scopus关键词	Sewage; Anti-cancer agents; Chemotherapeutic agents; Ecotoxicological assessment; Effective concentration; Environmental levels; Environmental risks; Fertilized eggs; Toxicity test; Toxicity; cisplatin; cyclophosphamide; tamoxifen; antineoplastic agent; assessment method; chemotherapy; concentration (composition); echinoderm; ecotoxicology; embryo; marine pollution; toxicity test; adult; animal cell; animal experiment; Article; Brazil; calculation; concentration (parameter); controlled study; EC50; ecotoxicity; embryo; embryo development; embryotoxicity; environment; female; gamete; male; marine species; Mellita quinquiesperforata; nonhuman; toxicity testing; zygote; animal; ecotoxicology; sea urchin; toxicity testing; water pollutant; Brazil; Clypeasteroida; Echinodermata; Mellita quinquiesperforata; Animals; Antineoplastic Agents; Brazil; Ecotoxicology; Sea Urchins; Toxicity Tests; Water Pollutants, Chemical
来源期刊	Marine Pollution Bulletin
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/148679
作者单位	Center of Studies on Aquatic Pollution and Ecoxicology (NEPEA), São Paulo State University - UNESP, São Vicente, SP 11330-900, Brazil; Centre for Marine and Environmental Research (CIMA), Universidade do Algarve, Campus de Gambelas, Faro, 8000-139, Portugal
推荐引用方式 GB/T 7714	Mello L.C.,da Fonseca T.G.,Denis Moledode de Souza A.. Ecotoxicological assessment of chemotherapeutic agents using toxicity tests with embryos of Mellita quinquiesperforata[J],2020,159.
APA	Mello L.C.,da Fonseca T.G.,&Denis Moledode de Souza A..(2020).Ecotoxicological assessment of chemotherapeutic agents using toxicity tests with embryos of Mellita quinquiesperforata.Marine Pollution Bulletin,159.
MLA	Mello L.C.,et al."Ecotoxicological assessment of chemotherapeutic agents using toxicity tests with embryos of Mellita quinquiesperforata".Marine Pollution Bulletin 159(2020).