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DOI	10.1126/science.aav6691
	Phase separation provides a mechanism to reduce noise in cells
	Klosin A.; Oltsch F.; Harmon T.; Honigmann A.; Jülicher F.; Hyman A.A.; Zechner C.
发表日期	2020
ISSN	0036-8075
起始页码	464
结束页码	468
卷号	367 期号:6476
英文摘要	Expression of proteins inside cells is noisy, causing variability in protein concentration among identical cells. A central problem in cellular control is how cells cope with this inherent noise. Compartmentalization of proteins through phase separation has been suggested as a potential mechanism to reduce noise, but systematic studies to support this idea have been missing. In this study, we used a physical model that links noise in protein concentration to theory of phase separation to show that liquid droplets can effectively reduce noise. We provide experimental support for noise reduction by phase separation using engineered proteins that form liquid-like compartments in mammalian cells. Thus, phase separation can play an important role in biological signal processing and control. Copyright © 2020 The Authors.
关键词	cell concentration (composition)noise phase transition protein separation article controlled study mammal cell noise reduction phase separation physical model signal processing theoretical study Mammalia
语种	英语
来源机构	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133770
推荐引用方式 GB/T 7714	Klosin A.,Oltsch F.,Harmon T.,et al. Phase separation provides a mechanism to reduce noise in cells[J]. Science,2020,367(6476).
APA	Klosin A..,Oltsch F..,Harmon T..,Honigmann A..,Jülicher F..,...&Zechner C..(2020).Phase separation provides a mechanism to reduce noise in cells.,367(6476).
MLA	Klosin A.,et al."Phase separation provides a mechanism to reduce noise in cells".367.6476(2020).