气候变化领域集成服务门户(CCPortal): Biocatalytic synthesis of planar chiral macrocycles

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DOI	10.1126/science.aaz7381
	Biocatalytic synthesis of planar chiral macrocycles
	Gagnon C.; Godin É.; Minozzi C.; Sosoe J.; Pochet C.; Collins S.K.
发表日期	2020
ISSN	0036-8075
起始页码	917
结束页码	921
卷号	367 期号:6480
英文摘要	Macrocycles can restrict the rotation of substituents through steric repulsions, locking in conformations that provide or enhance the activities of pharmaceuticals, agrochemicals, aroma chemicals, and materials. In many cases, the arrangement of substituents in the macrocycle imparts an element of planar chirality. The difficulty in predicting when planar chirality will arise, as well as the limited number of synthetic methods to impart selectivity, have led to planar chirality being regarded as an irritant. We report a strategy for enantio- and atroposelective biocatalytic synthesis of planar chiral macrocycles. The macrocycles can be formed with high enantioselectivity from simple building blocks and are decorated with functionality that allows one to further modify the macrocycles with diverse structural features. © 2020 American Association for the Advancement of Science. All rights reserved.
关键词	biochemical composition biochemistry catalyst enzyme enzyme activity molecular analysis article biocatalyst chirality enantioselectivity synthesis
语种	英语
来源机构	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133700
推荐引用方式 GB/T 7714	Gagnon C.,Godin É.,Minozzi C.,et al. Biocatalytic synthesis of planar chiral macrocycles[J]. Science,2020,367(6480).
APA	Gagnon C.,Godin É.,Minozzi C.,Sosoe J.,Pochet C.,&Collins S.K..(2020).Biocatalytic synthesis of planar chiral macrocycles.,367(6480).
MLA	Gagnon C.,et al."Biocatalytic synthesis of planar chiral macrocycles".367.6480(2020).