气候变化领域集成服务门户(CCPortal): Endoplasmic reticulum-associated degradation regulates mitochondrial dynamics in brown adipocytes

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DOI	10.1126/science.aay2494
	Endoplasmic reticulum-associated degradation regulates mitochondrial dynamics in brown adipocytes
	Zhou Z.; Torres M.; Sha H.; Halbrook C.J.; van den Bergh F.; Reinert R.B.; Yamada T.; Wang S.; Luo Y.; Hunter A.H.; Wang C.; Sanderson T.H.; Liu M.; Taylor A.; Sesaki H.; Lyssiotis C.A.; Wu J.; Kersten S.; Beard D.A.; Qi L.
发表日期	2020
ISSN	0036-8075
卷号	368 期号:6486
英文摘要	The endoplasmic reticulum (ER) engages mitochondria at specialized ER domains known as mitochondria-associated membranes (MAMs). Here, we used three-dimensional high-resolution imaging to investigate the formation of pleomorphic “megamitochondria” with altered MAMs in brown adipocytes lacking the Sel1L-Hrd1 protein complex of ER-associated protein degradation (ERAD). Mice with ERAD deficiency in brown adipocytes were cold sensitive and exhibited mitochondrial dysfunction. ERAD deficiency affected ER-mitochondria contacts and mitochondrial dynamics, at least in part, by regulating the turnover of the MAM protein, sigma receptor 1 (SigmaR1). Thus, our study provides molecular insights into ER-mitochondrial cross-talk and expands our understanding of the physiological importance of Sel1L-Hrd1 ERAD. © 2020 American Association for the Advancement of Science. All rights reserved.
关键词	Hrd1 protein membrane protein Sel1L protein sigma opiate receptor sigma receptor 1 ubiquitin protein ligase E3 unclassified drug biodegradation cell organelle membrane mitochondrion physiology protein turnover animal cell Article brown adipocyte cell contact controlled study endoplasmic reticulum endoplasmic reticulum associated degradation megamitochondria mitochondrial dynamics mitochondrion mouse nonhuman priority journal protein metabolism protein protein interaction thermogenesis three-dimensional imaging Mus
语种	英语
来源机构	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133583
推荐引用方式 GB/T 7714	Zhou Z.,Torres M.,Sha H.,et al. Endoplasmic reticulum-associated degradation regulates mitochondrial dynamics in brown adipocytes[J]. Science,2020,368(6486).
APA	Zhou Z..,Torres M..,Sha H..,Halbrook C.J..,van den Bergh F..,...&Qi L..(2020).Endoplasmic reticulum-associated degradation regulates mitochondrial dynamics in brown adipocytes.,368(6486).
MLA	Zhou Z.,et al."Endoplasmic reticulum-associated degradation regulates mitochondrial dynamics in brown adipocytes".368.6486(2020).