气候变化领域集成服务门户(CCPortal): Total synthesis of bryostatin 3

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DOI	10.1126/science.abb7271
	Total synthesis of bryostatin 3
	Trost B.M.; Wang Y.; Buckl A.K.; Huang Z.; Nguyen M.H.; Kuzmina O.
发表日期	2020
ISSN	0036-8075
起始页码	1007
结束页码	1011
卷号	368 期号:6494
英文摘要	Bryostatins are a family of 21 complex marine natural products with a wide range of potent biological activities. Among all the 21 bryostatins, bryostatin 3 is structurally the most complex. Whereas nine total syntheses of bryostatins have been achieved to date, bryostatin 3 has only been targeted once and required the highest number of steps to synthesize (43 steps in the longest linear sequence and 88 total steps). Here, we report a concise total synthesis of bryostatin 3 using 22 steps in the longest linear sequence and 31 total steps through a highly convergent synthetic plan by the use of highly atom-economical and chemoselective transformations in which alkynes played a major role in reducing step count. © 2020 American Association for the Advancement of Science. All rights reserved.
关键词	bioactivity marine environment protein alkyne biological product bryostatin bryostatin 3 macrolide chemistry synthesis Alkynes Biological Products Bryostatins Chemistry Techniques, Synthetic Macrolides
语种	英语
来源机构	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133462
推荐引用方式 GB/T 7714	Trost B.M.,Wang Y.,Buckl A.K.,et al. Total synthesis of bryostatin 3[J]. Science,2020,368(6494).
APA	Trost B.M.,Wang Y.,Buckl A.K.,Huang Z.,Nguyen M.H.,&Kuzmina O..(2020).Total synthesis of bryostatin 3.,368(6494).
MLA	Trost B.M.,et al."Total synthesis of bryostatin 3".368.6494(2020).