气候变化领域集成服务门户(CCPortal): Development of an inactivated vaccine candidate for SARS-CoV-2

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DOI	10.1126/science.abc1932
	Development of an inactivated vaccine candidate for SARS-CoV-2
	Gao Q.; Bao L.; Mao H.; Wang L.; Xu K.; Yang M.; Li Y.; Zhu L.; Wang N.; Lv Z.; Gao H.; Ge X.; Kan B.; Hu Y.; Liu J.; Cai F.; Jiang D.; Yin Y.; Qin C.; Li J.; Gong X.; Lou X.; Shi W.; Wu D.; Zhang H.; Zhu L.; Deng W.; Li Y.; Lu J.; Li C.; Wang X.; Yin W.; Zhang Y.; Qin C.
发表日期	2020
ISSN	10959203
起始页码	77
结束页码	81
卷号	369 期号:6499
英文摘要	The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in an unprecedented public health crisis. Because of the novelty of the virus, there are currently no SARS-CoV-2-specific treatments or vaccines available. Therefore, rapid development of effective vaccines against SARS-CoV-2 are urgently needed. Here, we developed a pilot-scale production of PiCoVacc, a purified inactivated SARS-CoV-2 virus vaccine candidate, which induced SARS-CoV-2-specific neutralizing antibodies in mice, rats, and nonhuman primates. These antibodies neutralized 10 representative SARS-CoV-2 strains, suggesting a possible broader neutralizing ability against other strains. Three immunizations using two different doses, 3 or 6 micrograms per dose, provided partial or complete protection in macaques against SARS-CoV-2 challenge, respectively, without observable antibody-dependent enhancement of infection. These data support the clinical development and testing of PiCoVacc for use in humans. Copyright © 2020, American Association for the Advancement of Science.
关键词	COVID-19 vaccine immunoglobulin G inactivated vaccine neutralizing antibody virus antibody virus vaccine animal Bagg albino mouse Betacoronavirus biosynthesis blood Chlorocebus aethiops Coronavirus infection dose response female immunology isolation and purification male mouse pandemic pilot study rat rhesus monkey vaccine immunogenicity Vero cell line virology virus load virus pneumonia Wistar rat Animals Antibodies, Neutralizing Antibodies, Viral Betacoronavirus Chlorocebus aethiops Coronavirus Infections Dose-Response Relationship, Immunologic Female Immunogenicity, Vaccine Immunoglobulin G Macaca mulatta Male Mice Mice, Inbred BALB C Pandemics Pilot Projects Pneumonia, Viral Rats Rats, Wistar Vaccines, Inactivated Vero Cells Viral Load Viral Vaccines
语种	英语
来源机构	Science (New York, N.Y.)
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133368
推荐引用方式 GB/T 7714	Gao Q.,Bao L.,Mao H.,et al. Development of an inactivated vaccine candidate for SARS-CoV-2[J]. Science (New York, N.Y.),2020,369(6499).
APA	Gao Q..,Bao L..,Mao H..,Wang L..,Xu K..,...&Qin C..(2020).Development of an inactivated vaccine candidate for SARS-CoV-2.,369(6499).
MLA	Gao Q.,et al."Development of an inactivated vaccine candidate for SARS-CoV-2".369.6499(2020).