气候变化领域集成服务门户(CCPortal): Cancer cells deploy lipocalin-2 to collect limiting iron in leptomeningeal metastasis

CCPortal

DOI	10.1126/science.aaz2193
	Cancer cells deploy lipocalin-2 to collect limiting iron in leptomeningeal metastasis
	Chi Y.; Remsik J.; Kiseliovas V.; Derderian C.; Sener U.; Alghader M.; Saadeh F.; Nikishina K.; Bale T.; Iacobuzio-Donahue C.; Thomas T.; Pe'er D.; Mazutis L.; Boire A.
发表日期	2020
ISSN	10959203
起始页码	276
结束页码	282
卷号	369 期号:6501
英文摘要	The tumor microenvironment plays a critical regulatory role in cancer progression, especially in central nervous system metastases. Cancer cells within the cerebrospinal fluid (CSF)-filled leptomeninges face substantial microenvironmental challenges, including inflammation and sparse micronutrients. To investigate the mechanism by which cancer cells in these leptomeningeal metastases (LM) overcome these constraints, we subjected CSF from five patients with LM to single-cell RNA sequencing. We found that cancer cells, but not macrophages, within the CSF express the iron-binding protein lipocalin-2 (LCN2) and its receptor SCL22A17. These macrophages generate inflammatory cytokines that induce cancer cell LCN2 expression but do not generate LCN2 themselves. In mouse models of LM, cancer cell growth is supported by the LCN2/SLC22A17 system and is inhibited by iron chelation therapy. Thus, cancer cells appear to survive in the CSF by outcompeting macrophages for iron. Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
语种	英语
来源机构	Science (New York, N.Y.)
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133323
推荐引用方式 GB/T 7714	Chi Y.,Remsik J.,Kiseliovas V.,et al. Cancer cells deploy lipocalin-2 to collect limiting iron in leptomeningeal metastasis[J]. Science (New York, N.Y.),2020,369(6501).
APA	Chi Y..,Remsik J..,Kiseliovas V..,Derderian C..,Sener U..,...&Boire A..(2020).Cancer cells deploy lipocalin-2 to collect limiting iron in leptomeningeal metastasis.,369(6501).
MLA	Chi Y.,et al."Cancer cells deploy lipocalin-2 to collect limiting iron in leptomeningeal metastasis".369.6501(2020).