气候变化领域集成服务门户(CCPortal): Intergenerational epigenetic inheritance in reef-building corals

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DOI	10.1038/s41558-019-0687-2
	Intergenerational epigenetic inheritance in reef-building corals
	Liew Y.J.; Howells E.J.; Wang X.; Michell C.T.; Burt J.A.; Idaghdour Y.; Aranda M.
发表日期	2020
ISSN	1758678X
卷号	10 期号:3
英文摘要	The perception that the inheritance of phenotypic traits operates solely through genetic means is slowly being eroded: epigenetic mechanisms have been shown to induce heritable changes in gene activity in plants1,2 and metazoans1,3. Inheritance of DNA methylation patterns provides a potential pathway for environmentally induced phenotypes to contribute to evolution of species and populations1–5. However, in basal metazoans, it is unknown whether inheritance of CpG methylation patterns occurs across the genome (as in plants) or as rare exceptions (as in mammals)4. Here, we show that DNA methylation patterns in a reef-building coral are determined by genotype and developmental stage, as well as by parental environment. Transmission of CpG methylation from adults to their sperm and larvae demonstrates genome-wide inheritance. Variation in the hypermethylation of genes in adults and their sperm from distinct environments suggests intergenerational acclimatization to local temperature and salinity. Furthermore, genotype-independent adjustments of methylation levels in stress-related genes were strongly correlated with offspring survival rates under heat stress. These findings support a role of DNA methylation in the intergenerational inheritance of traits in corals, which could extend to enhancing their capacity to adapt to climate change. © 2020, The Author(s), under exclusive licence to Springer Nature Limited.
语种	英语
scopus关键词	Anthozoa; Mammalia; Metazoa
来源期刊	Nature Climate Change
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/124215
作者单位	Red Sea Research Center, Biological and Environmental Sciences & Engineering Division, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia; Center for Genomics and Systems Biology and Program in Biology, New York University Abu Dhabi, Abu Dhabi, United Arab Emirates; CSIRO Health & Biosecurity, North Ryde, NSW, Australia; Centre for Sustainable Ecosystem Solutions, School of Earth, Atmospheric and Life Sciences, University of Wollongong, Wollongong, NSW, Australia; Center for Cardiovascular Regeneration, Houston Methodist, Houston, TX, United States; Department of Environmental and Biological Sciences, University of Eastern Finland, Joensuu, Finland
推荐引用方式 GB/T 7714	Liew Y.J.,Howells E.J.,Wang X.,et al. Intergenerational epigenetic inheritance in reef-building corals[J],2020,10(3).
APA	Liew Y.J..,Howells E.J..,Wang X..,Michell C.T..,Burt J.A..,...&Aranda M..(2020).Intergenerational epigenetic inheritance in reef-building corals.Nature Climate Change,10(3).
MLA	Liew Y.J.,et al."Intergenerational epigenetic inheritance in reef-building corals".Nature Climate Change 10.3(2020).