气候变化领域集成服务门户(CCPortal): Competing for blood: the ecology of parasite resource competition in human malaria

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DOI	10.1111/ele.12919
	Competing for blood: the ecology of parasite resource competition in human malaria–helminth co-infections
	Budischak S.A.; Wiria A.E.; Hamid F.; Wammes L.J.; Kaisar M.M.M.; van Lieshout L.; Sartono E.; Supali T.; Yazdanbakhsh M.; Graham A.L.
发表日期	2018
ISSN	1461023X
卷号	21 期号:4
英文摘要	Ecological theory suggests that co-infecting parasite species can interact within hosts directly, via host immunity and/or via resource competition. In mice, competition for red blood cells (RBCs) between malaria and bloodsucking helminths can regulate malaria population dynamics, but the importance of RBC competition in human hosts was unknown. We analysed infection density (i.e. the concentration of parasites in infected hosts), from a 2-year deworming study of over 4000 human subjects. After accounting for resource-use differences among parasites, we find evidence of resource competition, priority effects and a competitive hierarchy within co-infected individuals. For example reducing competition via deworming increased Plasmodium vivax densities 2.8-fold, and this effect is limited to bloodsucking hookworms. Our ecological, resource-based perspective sheds new light into decades of conflicting outcomes of malaria–helminth co-infection studies with significant health and transmission consequences. Beyond blood, investigating within-human resource competition may bring new insights for improving human health. © 2018 John Wiley & Sons Ltd/CNRS
英文关键词	Ascaris lumbricoides; co-infection interactions; Hookworms; Plasmodium falciparum; Plasmodium vivax; resource competition; within-host ecology
语种	英语
scopus关键词	Ancylostomatoidea; Ascaris lumbricoides; Mus; Plasmodium falciparum; Plasmodium vivax; Vermes; animal; complication; ecology; helminth; helminthiasis; human; malaria; mixed infection; mouse; parasite; Animals; Coinfection; Ecology; Helminthiasis; Helminths; Humans; Malaria; Mice; Parasites
来源期刊	Ecology Letters
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/121347
作者单位	Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, United States; Department of Parasitology, Leiden University Medical Center, Leiden, Netherlands; Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Microbiology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Department of Medical Microbiology, Erasmus MC, Rotterdam, Netherlands
推荐引用方式 GB/T 7714	Budischak S.A.,Wiria A.E.,Hamid F.,等. Competing for blood: the ecology of parasite resource competition in human malaria–helminth co-infections[J],2018,21(4).
APA	Budischak S.A..,Wiria A.E..,Hamid F..,Wammes L.J..,Kaisar M.M.M..,...&Graham A.L..(2018).Competing for blood: the ecology of parasite resource competition in human malaria–helminth co-infections.Ecology Letters,21(4).
MLA	Budischak S.A.,et al."Competing for blood: the ecology of parasite resource competition in human malaria–helminth co-infections".Ecology Letters 21.4(2018).