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DOI	10.1016/j.apr.2019.11.023
	Aqueous particulate matter (PM2.5) from Brazil alters antioxidant profile responses and causes oxidative stress
	de Paula Ribeiro J.; Cáceres Quijano M.F.; Ferreiro J.D.; Gioda A.; Jiménez-Vélez B.; Monserrat J.M.; Gioda C.R.
发表日期	2020
ISSN	13091042
卷号	11 期号:3
英文摘要	In vitro assays were used to determine the effects of aqueous fine particulate matter (PM2.5) extracts on different homogenates of rat organs. The PM2.5 collected from two regions (Seropédica and Duque de Caxias) in Rio de Janeiro, Brazil, were used to evaluate different oxidative damages and redox state. Two PM2.5 extract concentrations (concentrate and 10x dilution) were evaluated using rat tissue homogenates (heart, lung, liver, and kidney). Measurements of total antioxidant capacity (ACAP), lipid peroxidation levels (LPO), reduced glutathione concentrations (GSH), activity of glutamate cysteine ligase (GCL), activity of glutathione S-transferase (GST) and catalase (CAT) were performed. Most PM2.5 aqueous extract concentrations contain numerous metals (e.g. Li, Ti, Fe, Cu, Cd, Sr, among others), which reduced ACAP and generated LPO in most tissue homogenates. Besides this, GST activity decreased in liver and lung, increasing in kidney and heart homogenates. GCL activity increased in lung, liver and kidney and undergo decrease in the heart homogenate. All concentrations of PM2.5 evaluated decreased GSH levels. PM2.5 concentrations for both sites (regions) raised catalase activity in most tissue homogenates except in the liver. In vitro toxicity of the PM2.5 in different tissues, presented an ability to interact with cellular antioxidant defense system, causing depletion of the sulfhydryl stocks, resulting in the damage of biological molecules and inducing oxidative imbalance. © 2020 Turkish National Committee for Air Pollution Research and Control
英文关键词	Antioxidants systems; Fine particulate matter; GSH content; Lipid damage; Metals; Rat
语种	英语
来源期刊	Atmospheric Pollution Research
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/120572
作者单位	Instituto de Ciências Biológicas, Universidade Federal do Rio Grande, FURG, Rio Grande, RS, Brazil; Programa de Pós Graduação em Ciências Fisiológicas, Instituto de Ciências Biológicas, FURG, Rio Grande, RS, Brazil; Pontifícia Universidade Católica do Rio de Janeiro (PUC-Rio), Departamento de Química, Rio de Janeiro, RJ, Brazil; University of Puerto Rico, Medical Sciences Campus, School of Medicine, Department of BiochemistryS.J, Puerto Rico
推荐引用方式 GB/T 7714	de Paula Ribeiro J.,Cáceres Quijano M.F.,Ferreiro J.D.,et al. Aqueous particulate matter (PM2.5) from Brazil alters antioxidant profile responses and causes oxidative stress[J],2020,11(3).
APA	de Paula Ribeiro J..,Cáceres Quijano M.F..,Ferreiro J.D..,Gioda A..,Jiménez-Vélez B..,...&Gioda C.R..(2020).Aqueous particulate matter (PM2.5) from Brazil alters antioxidant profile responses and causes oxidative stress.Atmospheric Pollution Research,11(3).
MLA	de Paula Ribeiro J.,et al."Aqueous particulate matter (PM2.5) from Brazil alters antioxidant profile responses and causes oxidative stress".Atmospheric Pollution Research 11.3(2020).