气候变化领域集成服务门户(CCPortal): Bottom-up regulation of malaria population dynamics in mice co-infected with lung-migratory nematodes

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DOI	10.1111/ele.12534
	Bottom-up regulation of malaria population dynamics in mice co-infected with lung-migratory nematodes
	Griffiths E.C.; Fairlie-Clarke K.; Allen J.E.; Metcalf C.J.E.; Graham A.L.
发表日期	2015
ISSN	1461-023X
EISSN	1461-0248
卷号	18 期号:12
英文摘要	When and how populations are regulated by bottom up vs. top down processes, and how those processes are affected by co-occurring species, are poorly characterised across much of ecology. We are especially interested in the community ecology of parasites that must share a host. Here, we quantify how resources and immunity affect parasite propagation in experiments in near-replicate 'mesocosms'' - i.e. mice infected with malaria (Plasmodium chabaudi) and nematodes (Nippostrongylus brasiliensis). Nematodes suppressed immune responses against malaria, and yet malaria populations were smaller in co-infected hosts. Further analyses of within-host epidemiology revealed that nematode co-infection altered malaria propagation by suppressing target cell availability. This is the first demonstration that bottom-up resource regulation may have earlier and stronger effects than top-down immune mechanisms on within-host community dynamics. Our findings demonstrate the potential power of experimental ecology to disentangle mechanisms of population regulation in complex communities. © 2015 John Wiley & Sons Ltd/CNRS.
英文关键词	Co-infection; Community ecology; Effective propagation; Immune profile; Parasite ecology; Predator community; Resource regulation; Target cell limitation
学科领域	bottom-up control; cells and cell components; community ecology; epidemiology; experimental study; immune response; infectivity; malaria; nematode; population dynamics; predator-prey interaction; quantitative analysis; rodent; Mus; Nematoda; Nippostrongylus brasiliensis; Plasmodium chabaudi; animal; Bagg albino mouse; female; immunology; innate immunity; malaria; mixed infection; mouse; Nippostrongylus; parasitology; physiology; Plasmodium chabaudi; population dynamics; rodent disease; strongyle infection; Animals; Coinfection; Female; Immunity, Innate; Malaria; Mice; Mice, Inbred BALB C; Nippostrongylus; Plasmodium chabaudi; Population Dynamics; Rodent Diseases; Strongylida Infections
语种	英语
scopus关键词	bottom-up control; cells and cell components; community ecology; epidemiology; experimental study; immune response; infectivity; malaria; nematode; population dynamics; predator-prey interaction; quantitative analysis; rodent; Mus; Nematoda; Nippostrongylus brasiliensis; Plasmodium chabaudi; animal; Bagg albino mouse; female; immunology; innate immunity; malaria; mixed infection; mouse; Nippostrongylus; parasitology; physiology; Plasmodium chabaudi; population dynamics; rodent disease; strongyle infection; Animals; Coinfection; Female; Immunity, Innate; Malaria; Mice; Mice, Inbred BALB C; Nippostrongylus; Plasmodium chabaudi; Population Dynamics; Rodent Diseases; Strongylida Infections
来源期刊	Ecology Letters
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/118675
作者单位	Department of Entomology, Gardner Hall, Derieux Place, Raleigh, NC 27695-7613, United States; Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical and Veterinary Life Sciences, University of Glasgow, Glasgow, G61 1QH, United Kingdom; Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, EH8 9YL, United Kingdom; Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, United States; Fogarty International Center, National Institutes of Health, Bethesda, MD 20892, United States
推荐引用方式 GB/T 7714	Griffiths E.C.,Fairlie-Clarke K.,Allen J.E.,et al. Bottom-up regulation of malaria population dynamics in mice co-infected with lung-migratory nematodes[J],2015,18(12).
APA	Griffiths E.C.,Fairlie-Clarke K.,Allen J.E.,Metcalf C.J.E.,&Graham A.L..(2015).Bottom-up regulation of malaria population dynamics in mice co-infected with lung-migratory nematodes.Ecology Letters,18(12).
MLA	Griffiths E.C.,et al."Bottom-up regulation of malaria population dynamics in mice co-infected with lung-migratory nematodes".Ecology Letters 18.12(2015).