气候变化领域集成服务门户(CCPortal): Spatial structure, host heterogeneity and parasite virulence: Implications for vaccine-driven evolution

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DOI	10.1111/ele.12455
	Spatial structure, host heterogeneity and parasite virulence: Implications for vaccine-driven evolution
	Zurita-Gutiérrez Y.H.; Lion S.
发表日期	2015
ISSN	1461-023X
EISSN	1461-0248
卷号	18 期号:8
英文摘要	Natural host-parasite interactions exhibit considerable variation in host quality, with profound consequences for disease ecology and evolution. For instance, treatments (such as vaccination) may select for more transmissible or virulent strains. Previous theory has addressed the ecological and evolutionary impact of host heterogeneity under the assumption that hosts and parasites disperse globally. Here, we investigate the joint effects of host heterogeneity and local dispersal on the evolution of parasite life-history traits. We first formalise a general theoretical framework combining variation in host quality and spatial structure. We then apply this model to the specific problem of parasite evolution following vaccination. We show that, depending on the type of vaccine, spatial structure may select for higher or lower virulence compared to the predictions of non-spatial theory. We discuss the implications of our results for disease management, and their broader fundamental relevance for other causes of host heterogeneity in nature. © 2015 John Wiley & Sons Ltd/CNRS.
英文关键词	Dispersal; Epidemiology; Host-parasite interactions; Kin selection; Vaccination; Virulence management
学科领域	epidemiology; heterogeneity; host-parasite interaction; kin selection; life history trait; spatial distribution; vaccination; virulence; vaccine; biological model; evolution; genetics; host pathogen interaction; population genetics; virulence; Biological Evolution; Genetics, Population; Host-Pathogen Interactions; Models, Biological; Vaccines; Virulence
语种	英语
scopus关键词	epidemiology; heterogeneity; host-parasite interaction; kin selection; life history trait; spatial distribution; vaccination; virulence; vaccine; biological model; evolution; genetics; host pathogen interaction; population genetics; virulence; Biological Evolution; Genetics, Population; Host-Pathogen Interactions; Models, Biological; Vaccines; Virulence
来源期刊	Ecology Letters
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/118658
作者单位	Centre d'Écologie Fonctionnelle et Évolutive (CEFE), UMR 5175, CNRS - Université de Montpellier - Université Paul-Valéry Montpellier - EPHE., 1919 route de Mende, Montpellier Cedex 5, 34293, France
推荐引用方式 GB/T 7714	Zurita-Gutiérrez Y.H.,Lion S.. Spatial structure, host heterogeneity and parasite virulence: Implications for vaccine-driven evolution[J],2015,18(8).
APA	Zurita-Gutiérrez Y.H.,&Lion S..(2015).Spatial structure, host heterogeneity and parasite virulence: Implications for vaccine-driven evolution.Ecology Letters,18(8).
MLA	Zurita-Gutiérrez Y.H.,et al."Spatial structure, host heterogeneity and parasite virulence: Implications for vaccine-driven evolution".Ecology Letters 18.8(2015).