气候变化领域集成服务门户(CCPortal): Environmental variability and the evolution of the glucocorticoid receptor (Nr3c1) in African starlings

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DOI	10.1111/ele.12656
	Environmental variability and the evolution of the glucocorticoid receptor (Nr3c1) in African starlings
	Hofmeister N.R.; Rubenstein D.R.
发表日期	2016
ISSN	1461-023X
EISSN	1461-0248
卷号	19 期号:10
英文摘要	One of the primary ways that organisms cope with environmental change is through regulation of the hypothalamo-pituitary-adrenal (HPA) axis, the neuroendocrine system that controls reactions to stress. Variation in genes regulating the HPA axis - particularly the glucocorticoid receptor - may facilitate adaptation to changing climatic conditions by altering expression. Here we examine signatures of selection on the glucocorticoid receptor gene (Nr3c1) in African starlings that inhabit a range of environments, including those with variable climatic conditions. To investigate potential adaptive mechanisms underlying the vertebrate stress response, we sequence the Nr3c1 gene in 27 species of African starlings. Although we find some evidence of positive selection, substitution rate is negatively correlated with variance in precipitation. This suggests climatic cycling in sub-Saharan Africa may have resulted in lower substitution rates to maintain a successful coping strategy. When environmental conditions fluctuate rapidly, variation in the strength of purifying selection can explain evolutionary rate variation. © 2016 John Wiley & Sons Ltd/CNRS.
英文关键词	Adaptation; canalisation; environmental variability; fluctuating selection; stress response
学科领域	glucocorticoid receptor; adaptation; animal; ecosystem; genetics; metabolism; molecular evolution; Passeriformes; physiology; Adaptation, Physiological; Animals; Ecosystem; Evolution, Molecular; Passeriformes; Receptors, Glucocorticoid; Sturnidae; Vertebrata
语种	英语
scopus关键词	glucocorticoid receptor; adaptation; animal; ecosystem; genetics; metabolism; molecular evolution; Passeriformes; physiology; Adaptation, Physiological; Animals; Ecosystem; Evolution, Molecular; Passeriformes; Receptors, Glucocorticoid; Sturnidae; Vertebrata
来源期刊	Ecology letters
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/118485
作者单位	Department of Ecology, Evolution and Environmental Biology, Columbia University, 1200 Amsterdam Avenue, New York, NY, 10027, USA. nrh44@cornell.edu; Department of Ecology, Evolution and Environmental Biology, Columbia University, 1200 Amsterdam Avenue, New York, NY, 10027, USA, United States; Center for Integrative Animal Behavior, Columbia University, 1200 Amsterdam Avenue, New York, NY, 10027, USA, United States
推荐引用方式 GB/T 7714	Hofmeister N.R.,Rubenstein D.R.. Environmental variability and the evolution of the glucocorticoid receptor (Nr3c1) in African starlings[J],2016,19(10).
APA	Hofmeister N.R.,&Rubenstein D.R..(2016).Environmental variability and the evolution of the glucocorticoid receptor (Nr3c1) in African starlings.Ecology letters,19(10).
MLA	Hofmeister N.R.,et al."Environmental variability and the evolution of the glucocorticoid receptor (Nr3c1) in African starlings".Ecology letters 19.10(2016).