气候变化领域集成服务门户(CCPortal): Age-specific infectious period shapes dynamics of pneumonia in bighorn sheep

CCPortal

DOI	10.1111/ele.12829
	Age-specific infectious period shapes dynamics of pneumonia in bighorn sheep
	Plowright R.K.; Manlove K.R.; Besser T.E.; Páez D.J.; Andrews K.R.; Matthews P.E.; Waits L.P.; Hudson P.J.; Cassirer E.F.
发表日期	2017
ISSN	1461-023X
EISSN	1461-0248
卷号	20 期号:10
英文摘要	Superspreading, the phenomenon where a small proportion of individuals contribute disproportionately to new infections, has profound effects on disease dynamics. Superspreading can arise through variation in contacts, infectiousness or infectious periods. The latter has received little attention, yet it drives the dynamics of many diseases of critical public health, livestock health and conservation concern. Here, we present rare evidence of variation in infectious periods underlying a superspreading phenomenon in a free-ranging wildlife system. We detected persistent infections of Mycoplasma ovipneumoniae, the primary causative agent of pneumonia in bighorn sheep (Ovis canadensis), in a small number of older individuals that were homozygous at an immunologically relevant genetic locus. Interactions among age-structure, genetic composition and infectious periods may drive feedbacks in disease dynamics that determine the magnitude of population response to infection. Accordingly, variation in initial conditions may explain divergent population responses to infection that range from recovery to catastrophic decline and extirpation. © 2017 John Wiley & Sons Ltd/CNRS
英文关键词	bighorn sheep; disease dynamics; feedback mechanism; Mycoplasma ovipneumoniae; pathogen persistence; persistent carriage; pneumonia; supershedder; superspreader; wildlife health
学科领域	Mycoplasma ovipneumoniae; Ovis canadensis; animal; bighorn sheep; Mycoplasma ovipneumoniae; Mycoplasma pneumonia; pneumonia; sheep; sheep disease; veterinary; wild animal; Animals; Animals, Wild; Mycoplasma ovipneumoniae; Pneumonia; Pneumonia, Mycoplasma; Sheep; Sheep Diseases; Sheep, Bighorn
语种	英语
scopus关键词	Mycoplasma ovipneumoniae; Ovis canadensis; animal; bighorn sheep; Mycoplasma ovipneumoniae; Mycoplasma pneumonia; pneumonia; sheep; sheep disease; veterinary; wild animal; Animals; Animals, Wild; Mycoplasma ovipneumoniae; Pneumonia; Pneumonia, Mycoplasma; Sheep; Sheep Diseases; Sheep, Bighorn
来源期刊	Ecology Letters
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/118330
作者单位	Department of Microbiology and Immunology, Montana State University, 109 Lewis Hall, Bozeman, MT 59717, United States; Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164, United States; Department of Fish and Wildlife Sciences, University of Idaho, 875 Perimeter Drive MS 1136, Moscow, ID 83844, United States; Oregon Department of Fish and Wildlife, 65495 Alder Slope Road, Enterprise, OR 97828, United States; Center for Infectious Disease Dynamics, Pennsylvania State University, 201, Life Sciences Building, University Park, PA 16802, United States; Idaho Department of Fish and Game, 3316 16th Street, Lewiston, ID 83501, United States
推荐引用方式 GB/T 7714	Plowright R.K.,Manlove K.R.,Besser T.E.,et al. Age-specific infectious period shapes dynamics of pneumonia in bighorn sheep[J],2017,20(10).
APA	Plowright R.K..,Manlove K.R..,Besser T.E..,Páez D.J..,Andrews K.R..,...&Cassirer E.F..(2017).Age-specific infectious period shapes dynamics of pneumonia in bighorn sheep.Ecology Letters,20(10).
MLA	Plowright R.K.,et al."Age-specific infectious period shapes dynamics of pneumonia in bighorn sheep".Ecology Letters 20.10(2017).