气候变化领域集成服务门户(CCPortal): Genome-wide association study of flowering time and grain yield traits in a worldwide collection of rice germplasm

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DOI	10.1038/ng.1018
	Genome-wide association study of flowering time and grain yield traits in a worldwide collection of rice germplasm
	Huang, Xuehui; Zhao, Yan; Wei, Xinghua; Li, Canyang; Wang, Ahong; Zhao, Qiang; Li, Wenjun; Guo, Yunli; Deng, Liuwei; Zhu, Chuanrang; Fan, Danlin; Lu, Yiqi; Weng, Qijun; Liu, Kunyan; Zhou, Taoying; Jing, Yufeng; Si, Lizhen; Dong, Guojun; Huang, Tao; Lu, Tingting; Feng, Qi; Qian, Qian; Li, Jiayang; Han, Bin
发表日期	2012
ISSN	1061-4036
卷号	44 期号:1
英文摘要	A high-density haplotype map recently enabled a genome-wide association study (GWAS) in a population of indica subspecies of Chinese rice landraces. Here we extend this methodology to a larger and more diverse sample of 950 worldwide rice varieties, including the Oryza sativa indica and Oryza sativa japonica subspecies, to perform an additional GWAS. We identified a total of 32 new loci associated with flowering time and with ten grain-related traits, indicating that the larger sample increased the power to detect trait-associated variants using GWAS. To characterize various alleles and complex genetic variation, we developed an analytical framework for haplotype-based de novo assembly of the low-coverage sequencing data in rice. We identified candidate genes for 18 associated loci through detailed annotation. This study shows that the integrated approach of sequence-based GWAS and functional genome annotation has the potential to match complex traits to their causal polymorphisms in rice.
学科领域	Genetics & Heredity
语种	英语
WOS研究方向	Genetics & Heredity
来源期刊	NATURE GENETICS
来源机构	中国科学院西北生态环境资源研究院
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/111676
作者单位	Chinese Acad Sci, Natl Ctr Gene Res, Natl Ctr Plant Gene Res Shanghai, Inst Plant Physiol & Ecol,Shanghai Inst Biol Sci, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Huang, Xuehui,Zhao, Yan,Wei, Xinghua,et al. Genome-wide association study of flowering time and grain yield traits in a worldwide collection of rice germplasm[J]. 中国科学院西北生态环境资源研究院,2012,44(1).
APA	Huang, Xuehui.,Zhao, Yan.,Wei, Xinghua.,Li, Canyang.,Wang, Ahong.,...&Han, Bin.(2012).Genome-wide association study of flowering time and grain yield traits in a worldwide collection of rice germplasm.NATURE GENETICS,44(1).
MLA	Huang, Xuehui,et al."Genome-wide association study of flowering time and grain yield traits in a worldwide collection of rice germplasm".NATURE GENETICS 44.1(2012).