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DOI10.1002/1873-3468.13549
Global changes in chromatin accessibility and transcription following ATRX inactivation in human cancer cells
Liang, Junbo1; Liu, Hongchao1; Li, Guangyu1; Qian, Jun1; Gao, Ran1; Zhou, Yanchi2; Wang, Xiaoyue1
发表日期2019
ISSN0014-5793
EISSN1873-3468
英文摘要

alpha-Tthalassemia mental retardation X-linked (ATRX) is a chromatin remodeler frequently mutated in many cancers. Despite the binding pattern of ATRX in heterochromatin, ATRX-mediated epigenomic changes in cancer cells have not been profiled, especially for the heterochromatin regions. Here, we profiled genome-wide maps of chromatin accessibility in ATRX-intact and ATRX-null human cancer cells. We found extensive changes in chromatin accessibility in both repetitive DNA regions and non-repetitive regulatory regions following ATRX loss. These changes are highly correlated with changes in transcription, which lead to alterations in cancer-related signalling pathways, such as upregulation of the TGF-beta pathway and downregulation of the cadherin family of proteins. These findings indicate that ATRX deficiency induces epigenomic changes and promotes tumorigenesis through both genome instability and shifts in transcription.


WOS研究方向Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
来源期刊FEBS LETTERS
文献类型期刊论文
条目标识符http://gcip.llas.ac.cn/handle/2XKMVOVA/101773
作者单位1.Chinese Acad Med Sci, Peking Union Med Coll, Inst Basic Med Sci, State Key Lab Med Mol Biol, Beijing 100005, Peoples R China;
2.Chinese Acad Med Sci, Canc Hosp, Peking Union Med Coll, Natl Canc Ctr, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Liang, Junbo,Liu, Hongchao,Li, Guangyu,et al. Global changes in chromatin accessibility and transcription following ATRX inactivation in human cancer cells[J],2019.
APA Liang, Junbo.,Liu, Hongchao.,Li, Guangyu.,Qian, Jun.,Gao, Ran.,...&Wang, Xiaoyue.(2019).Global changes in chromatin accessibility and transcription following ATRX inactivation in human cancer cells.FEBS LETTERS.
MLA Liang, Junbo,et al."Global changes in chromatin accessibility and transcription following ATRX inactivation in human cancer cells".FEBS LETTERS (2019).
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