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Structure and selectivity engineering of the M1 muscarinic receptor toxin complex 期刊论文
, 2020, 卷号: 369, 期号: 6500
作者:  Maeda S.;  Xu J.;  N Kadji F.M.;  Clark M.J.;  Zhao J.;  Tsutsumi N.;  Aoki J.;  Sunahara R.K.;  Inoue A.;  Garcia K.C.;  Kobilka B.K.
收藏  |  浏览/下载：56/0  |  提交时间：2020/07/28
atropine  m1-toxin  muscarinic M1 receptor  muscarinic receptor blocking agent  snake venom  animal  chemistry  genetic engineering  genetics  protein conformation  Sf9 cell line  X ray crystallography  Animals  Atropine  Crystallography, X-Ray  Elapid Venoms  Genetic Engineering  Muscarinic Antagonists  Protein Conformation  Receptor, Muscarinic M1  Sf9 Cells  
Dopamine promotes cognitive effort by biasing the benefits versus costs of cognitive work 期刊论文
, 2020, 卷号: 367, 期号: 6484
作者:  Westbrook A.;  van den Bosch R.;  Määttä J.I.;  Hofmans L.;  Papadopetraki D.;  Cools R.;  Frank M.J.
收藏  |  浏览/下载：40/0  |  提交时间：2020/07/28
dopamine  dopamine 2 receptor  methylphenidate  sulpiride  dopamine  dopamine 2 receptor blocking agent  dopamine uptake inhibitor  brain  cost-benefit analysis  decision making  hormone  sampling  adult  Article  cognition  cost benefit analysis  decision making  dopamine metabolism  female  gaze  human  human experiment  male  memory consolidation  motivation  normal human  priority journal  receptor blocking  striate cortex  task performance  adolescent  biosynthesis  caudate nucleus  cognition  corpus striatum  drug effect  eye fixation  memory  metabolism  reward  saccadic eye movement  signal transduction  young adult  Adolescent  Caudate Nucleus  Choice Behavior  Cognition  Corpus Striatum  Decision Making  Dopamine  Dopamine D2 Receptor Antagonists  Dopamine Uptake Inhibitors  Female  Fixation, Ocular  Humans  Male  Memory  Methylphenidate  Motivation  Reward  Saccades  Signal Transduction  Sulpiride  Young Adult  
Determination of the melanocortin-4 receptor structure identifies Ca2+ as a cofactor for ligand binding 期刊论文
, 2020, 卷号: 368, 期号: 6489
作者:  Yu J.;  Gimenez L.E.;  Hernandez C.C.;  Wu Y.;  Wein A.H.;  Han G.W.;  McClary K.;  Mittal S.R.;  Burdsall K.;  Stauch B.;  Wu L.;  Stevens S.N.;  Peisley A.;  Williams S.Y.;  Chen V.;  Millhauser G.L.;  Zhao S.;  Cone R.D.;  Stevens R.C.
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alpha intermedin  calcium ion  cyclic AMP  G protein coupled receptor  heterotrimeric guanine nucleotide binding protein  inwardly rectifying potassium channel  inwardly rectifying potassium channel subunit Kir7.1  melanocortin 4 receptor  n acetyl alpha intermedin[4-10]cyclo[4 norleucine 5 aspartic acid 7 [3 (2 naphthyl)alanine] 10 lysinamide]  unclassified drug  calcium  G protein coupled receptor  intermedin  inwardly rectifying potassium channel  Kir7.1 channel  ligand  melanocortin 4 receptor  n acetyl alpha intermedin[4-10]cyclo[4 norleucine 5 aspartic acid 7 [3 (2 naphthyl)alanine] 10 lysinamide]  protein binding  calcium  chemical binding  homeostasis  hormone  ligand  obesity  peptide  protein  Article  binding affinity  complex formation  crystallization  drug structure  extracellular calcium  human  ligand binding  priority journal  protein structure  receptor blocking  signal transduction  chemistry  genetics  mutation  protein multimerization  protein secondary structure  X ray crystallography  Calcium  Crystallography, X-Ray  Cyclic AMP  Humans  Ligands  Melanocyte-Stimulating Hormones  Mutation  Potassium Channels, Inwardly Rectifying  Protein Binding  Protein Multimerization  Protein Structure, Secondary  Receptor, Melanocortin, Type 4  Receptors, G-Protein-Coupled  Signal Transduction