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CFLIPL protects macrophages from LPS-induced pyroptosis via inhibition of complex II formation 期刊论文
, 2020, 卷号: 367, 期号: 6484
作者:  Muendlein H.I.;  Jetton D.;  Connolly W.M.;  Eidell K.P.;  Magri Z.;  Smirnova I.;  Poltorak A.
收藏  |  浏览/下载:49/0  |  提交时间:2020/07/28
FLICE inhibitory protein  interleukin 1beta  lipopolysaccharide  messenger RNA  succinate dehydrogenase (ubiquinone)  Casp1 protein, mouse  caspase 8  Cflar protein, mouse  cryopyrin  FLICE inhibitory protein  IL1B protein, mouse  inflammasome  interleukin 1beta  interleukin 1beta converting enzyme  lipopolysaccharide  succinate dehydrogenase (ubiquinone)  cell  enzyme activity  inhibition  maturation  protein  animal cell  animal experiment  Article  bone marrow derived macrophage  cell death  cell protection  complex formation  controlled study  cytokine release  in vitro study  inflammation  mouse  nonhuman  priority journal  protein analysis  protein degradation  protein function  protein interaction  pyroptosis  animal  gene knockdown  genetics  immunology  macrophage  macrophage activation  metabolism  physiology  Murinae  Animals  CASP8 and FADD-Like Apoptosis Regulating Protein  Caspase 1  Caspase 8  Electron Transport Complex II  Gene Knockdown Techniques  Inflammasomes  Interleukin-1beta  Lipopolysaccharides  Macrophage Activation  Macrophages  Mice  NLR Family, Pyrin Domain-Containing 3 Protein  Pyroptosis  
Structural basis of Gs and Gi recognition by the human glucagon receptor 期刊论文
, 2020, 卷号: 367, 期号: 6484
作者:  Qiao A.;  Han S.;  Li X.;  Li Z.;  Zhao P.;  Dai A.;  Chang R.;  Tai L.;  Tan Q.;  Chu X.;  Ma L.;  Thorsen T.S.;  Reedtz-Runge S.;  Yang D.;  Wang M.-W.;  Sexton P.M.;  Wootten D.;  Sun F.;  Zhao Q.;  Wu B.
收藏  |  浏览/下载:44/0  |  提交时间:2020/07/28
cyclic AMP  glucagon  glucagon receptor  inhibitory guanine nucleotide binding protein  stimulatory guanine nucleotide binding protein  glucagon receptor  inhibitory guanine nucleotide binding protein  protein binding  stimulatory guanine nucleotide binding protein  chemical binding  enzyme activity  gene expression  mutagenicity  protein  alpha helix  Article  binding affinity  carboxy terminal sequence  conformational transition  cryoelectron microscopy  human  molecular recognition  mutagenesis  priority journal  protein binding  protein function  protein protein interaction  protein structure  signal transduction  binding site  chemistry  metabolism  molecular model  protein conformation  ultrastructure  Binding Sites  Cryoelectron Microscopy  Glucagon  GTP-Binding Protein alpha Subunits, Gi-Go  GTP-Binding Protein alpha Subunits, Gs  Humans  Models, Molecular  Protein Binding  Protein Conformation  Protein Conformation, alpha-Helical  Receptors, Glucagon  Signal Transduction  
Dopaminylation of histone H3 in ventral tegmental area regulates cocaine seeking 期刊论文
, 2020, 卷号: 368, 期号: 6487
作者:  Lepack A.E.;  Werner C.T.;  Stewart A.F.;  Fulton S.L.;  Zhong P.;  Farrelly L.A.;  Smith A.C.W.;  Ramakrishnan A.;  Lyu Y.;  Bastle R.M.;  Martin J.A.;  Mitra S.;  O'Connor R.M.;  Wang Z.-J.;  Molina H.;  Turecki G.;  Shen L.;  Yan Z.;  Calipari E.S.;  Dietz D.M.;  Kenny P.J.;  Maze I.
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amidase  dopamine  histone H3  histone transamidase  protein glutamine gamma glutamyltransferase 2  RNA  unclassified drug  brain  cell  chemical compound  chemical reaction  gene expression  genetic analysis  protein  action potential  amino acid substitution  amino terminal sequence  Article  cocaine dependence  controlled study  dopamine release  dopaminergic nerve cell  dopaminergic transmission  down regulation  drug seeking behavior  enzyme activity  gene expression  histone dopaminylation  histone modification  human  human tissue  hyperpolarization  in vitro study  motivation  nerve cell plasticity  nerve projection  neuropathology  nucleus accumbens  priority journal  protein expression  protein function  reward  RNA sequence  ventral tegmentum  Rattus  
Marching to another clock 期刊论文
, 2020, 卷号: 367, 期号: 6479
作者:  Brown S.A.;  Sato M.
收藏  |  浏览/下载:42/0  |  提交时间:2020/07/28
RNA  transcription factor ARNTL  transcription factor CLOCK  transcription factor Ets  brain  circadian rhythm  molecular analysis  physiological response  protein  animal cell  animal tissue  Article  binding site  cell metabolism  circadian rhythm  controlled study  feedback system  genetic transcription  molecular dynamics  mouse  nonhuman  oxidation reduction reaction  priority journal  protein analysis  protein binding  protein expression  protein function  RNA analysis  RNA transcription  RNA translation  suprachiasmatic nucleus  music  walking  Circadian Rhythm  Music  Walking  
VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance 期刊论文
, 2020, 卷号: 367, 期号: 6475
作者:  ElTanbouly M.A.;  Zhao Y.;  Nowak E.;  Li J.;  Schaafsma E.;  Le Mercier I.;  Ceeraz S.;  Lines J.L.;  Peng C.;  Carriere C.;  Huang X.;  Day M.;  Koehn B.;  Lee S.W.;  Morales M.S.;  Hogquist K.A.;  Jameson S.C.;  Mueller D.;  Rothstein J.;  Blazar B.R.;  Cheng C.;  Noelle R.J.
收藏  |  浏览/下载:57/0  |  提交时间:2020/07/28
cell protein  interferon  kruppel like factor 2  T lymphocyte receptor  unclassified drug  V type immunoglobulin domain containing suppressor of T cell activation protein  B7 antigen  Dies1 protein, mouse  lymphocyte antigen receptor  membrane protein  monoclonal antibody  VSIR protein, human  biological development  cell  gene expression  heterogeneity  homeostasis  immune response  immunity  tolerance  acute graft versus host disease  animal cell  animal experiment  animal model  Article  CD4+ T lymphocyte  cell death  cell expansion  cell fate  cell heterogeneity  cell loss  cell survival  controlled study  female  gene  gene deletion  homeostasis  immunological tolerance  in vivo study  long term survival  male  mouse  nonhuman  phenotype  priority journal  protein expression  protein function  rheumatoid arthritis  RNA sequencing  systemic lupus erythematosus  T lymphocyte  T lymphocyte activation  T lymphocyte subpopulation  TCR gene  upregulation  VISTA gene  animal  C57BL mouse  genetics  immunological tolerance  immunology  knockout mouse  lymphocyte activation  physiology  T lymphocyte  Mus  Animals  Antibodies, Monoclonal  B7 Antigens  Lymphocyte Activation  Membrane Proteins  Mice  Mice, Inbred C57BL  Mice, Knockout  Peripheral Tolerance  Receptors, Antigen, T-Cell  T-Lymphocytes  
Peptide signaling for drought-induced tomato flower drop 期刊论文
, 2020, 卷号: 367, 期号: 6485
作者:  Reichardt S.;  Piepho H.-P.;  Stintzi A.;  Schaller A.
收藏  |  浏览/下载:42/0  |  提交时间:2020/07/28
mitogen activated protein kinase  peptide hormone  phytaspase 2  phytosulfokine  unclassified drug  abscission  aspartic acid  crop yield  drought stress  enzyme activity  flower  fruit  gene expression  hormone  peptide  abscission  Arabidopsis  Article  bioassay  cell separation  controlled study  cytokine production  down regulation  drought  environmental stress  enzyme activity  enzyme specificity  ERF4 gene  ERT10 gene  flower  hydrolysis  hydrophobicity  IAA3 gene  immunomodulation  molecular dynamics  nonhuman  peptide signaling  PK7 gene  plant development  plant genome  priority journal  productivity  protein cleavage  protein degradation  protein expression  protein function  protein processing  regulator gene  signal transduction  tomato  TPRP gene  Lycopersicon esculentum  
Structural insights into immunoglobulin M 期刊论文
, 2020, 卷号: 367, 期号: 6481
作者:  Li Y.;  Wang G.;  Li N.;  Wang Y.;  Zhu Q.;  Chu H.;  Wu W.;  Tan Y.;  Yu F.;  Su X.-D.;  Gao N.;  Xiao J.
收藏  |  浏览/下载:43/0  |  提交时间:2020/07/28
immunoglobulin M  secretory component  antibody  immunity  molecular analysis  polymer  protein  Article  binding site  conformational transition  cryoelectron microscopy  crystal structure  human  hydrophobicity  nonhuman  oligomerization  priority journal  protein assembly  protein domain  protein function  protein interaction  protein stability  protein structure  protein transport  surface area  
Structure of nucleosome-bound human BAF complex 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者:  He S.;  Wu Z.;  Tian Y.;  Yu Z.;  Yu J.;  Wang X.;  Li J.;  Liu B.;  Xu Y.
收藏  |  浏览/下载:38/0  |  提交时间:2020/07/28
actin related protein  adenosine triphosphatase  BRG1 BRM associated factor  DNA  multiprotein complex  protein SWI  retinoblastoma binding protein 2  SMARCC protein  SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily B member 1  transcription factor  transcription factor SNF  unclassified drug  cancer  enzyme activity  gene expression  hydrolysis  mutation  protein  alpha helix  Article  carboxy terminal sequence  cell interaction  cryoelectron microscopy  disease association  human  malignant neoplasm  molecular recognition  mutation  nucleosome  priority journal  protein function  protein hydrolysis  protein structure  structure analysis  Mammalia  
Vertebrate diapause preserves organisms long term through Polycomb complex members 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者:  Hu C.-K.;  Wang W.;  Brind'Amour J.;  Singh P.P.;  Adam Reeves G.;  Lorincz M.C.;  Alvarado A.S.;  Brunet A.
收藏  |  浏览/下载:44/0  |  提交时间:2020/07/28
polycomb group protein  protein CBX7  transcriptome  unclassified drug  diapause  gene expression  metabolism  muscle  vertebrate  Article  chromatin  complex formation  developmental gene  diapause  down regulation  embryo development  fertility  gene  gene expression regulation  gene repression  genetic regulation  growth rate  lifespan  lipid metabolism  metabolism  muscle atrophy  muscle gene  neuromuscular junction  nonhuman  priority journal  protein function  tissue preservation  upregulation  vertebrate  Cyprinodontoidei  Nothobranchius furzeri  Vertebrata  
A Kelch13-defined endocytosis pathway mediates artemisinin resistance in malaria parasites 期刊论文
, 2020, 卷号: 367, 期号: 6473
作者:  Birnbaum J.;  Scharf S.;  Schmidt S.;  Jonscher E.;  Maria Hoeijmakers W.A.;  Flemming S.;  Toenhake C.G.;  Schmitt M.;  Sabitzki R.;  Bergmann B.;  Fröhlke U.;  Mesén-Ramírez P.;  Soares A.B.;  Herrmann H.;  Bártfai R.;  Spielmann T.
收藏  |  浏览/下载:40/0  |  提交时间:2020/07/28
artemisinin  artemisinin derivative  cytosol receptor  hemoglobin  protein Kelch13  protozoal protein  unclassified drug  antimalarial agent  cell  drug resistance  hemoglobin  malaria  mutation  physiology  protein  antimalarial drug resistance  Article  controlled study  endocytosis  gene inactivation  gene mutation  host cell  Kelch13 gene  nonhuman  Plasmodium  priority journal  protein analysis  protein function