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| Elesclomol alleviates Menkes pathology and mortality by escorting Cu to cuproenzymes in mice 期刊论文
, 2020, 卷号: 368, 期号: 6491
作者: Guthrie L.M.; Soma S.; Yuan S.; Silva A.; Zulkifli M.; Snavely T.C.; Greene H.F.; Nunez E.; Lynch B.; de Ville C.; Shanbhag V.; Lopez F.R.; Acharya A.; Petris M.J.; Kim B.-E.; Gohil V.M.; Sacchettini J.C.
  收藏 | 浏览/下载：47/0 | 提交时间：2020/07/28
copper copper zinc superoxide dismutase cytochrome c oxidase dopamine beta monooxygenase elesclomol monophenol monooxygenase protein lysine 6 oxidase copper cytochrome c oxidase elesclomol hydrazine derivative copper cytochrome enzyme enzyme activity mitochondrion mortality mutation pathology rodent survival animal cell animal experiment animal model animal tissue Article cohort analysis controlled study disease severity drug mechanism Golgi complex H9c2(2-1) cell line in vivo study male Menkes syndrome mitochondrial dynamics mortality rate mouse nerve degeneration nonhuman priority journal secretory pathway survival rate animal brain cell line degenerative disease disease model drug effect genetics knockout mouse Menkes syndrome metabolism mitochondrion pathology rat transport at the cellular level Murinae Mus Animals Biological Transport Brain Cell Line Copper Copper Transporter 1 Disease Models, Animal Electron Transport Complex IV Hydrazines Male Menkes Kinky Hair Syndrome Mice Mice, Knockout Mitochondria Neurodegenerative Diseases Rats |
| PE/PPE proteins mediate nutrient transport across the outer membrane of Mycobacterium tuberculosis 期刊论文
, 2020, 卷号: 367, 期号: 6482
作者: Wang Q.; Boshoff H.I.M.; Harrison J.R.; Ray P.C.; Green S.R.; Wyatt P.G.; Barry Iii C.E.
收藏 | 浏览/下载：35/0 | 提交时间：2020/07/28
3,3 bis di(methylsulfonyl)propionamide antiinfective agent bacterial protein glucose glycerol magnesium phosphate propionamide derivative protein proline proline glutamate protein proline proline glutamate 51 unclassified drug amide bacterial protein lipid phthiocerol dimycocerosate propionamide thiol derivative cell component chemical compound membrane mutation protein tuberculosis antibiotic resistance Article bacterial cell bacterial cell wall bacterial growth bacterial outer membrane cell division drug structure Mycobacterium tuberculosis nonhuman nutrient uptake priority journal protein depletion cell membrane cell membrane permeability chemistry drug effect gene deletion genetics metabolism transport at the cellular level Mycobacterium tuberculosis Amides Bacterial Proteins Biological Transport Cell Membrane Cell Membrane Permeability Drug Resistance, Bacterial Gene Deletion Glucose Glycerol Lipids Mycobacterium tuberculosis Sulfhydryl Compounds |
| Helical quantum Hall phase in graphene on SrTiO3 期刊论文
, 2020, 卷号: 367, 期号: 6479
作者: Veyrat L.; Déprez C.; Coissard A.; Li X.; Gay F.; Watanabe K.; Taniguchi T.; Han Z.; Piot B.A.; Sellier H.; Sacépé B.
收藏 | 浏览/下载：49/0 | 提交时间：2020/07/28
graphene metal oxide strontium titanate unclassified drug experimental study magnetic field temperature effect topology Article controlled study dielectric constant magnetic field prediction priority journal quantum mechanics temperature |
| On impact and volcanism across the Cretaceous-Paleogene boundary 期刊论文
, 2020, 卷号: 367, 期号: 6475
作者: Hull P.M.; Bornemann A.; Penman D.E.; Henehan M.J.; Norris R.D.; Wilson P.A.; Blum P.; Alegret L.; Batenburg S.J.; Bown P.R.; Bralower T.J.; Cournede C.; Deutsch A.; Donner B.; Friedrich O.; Jehle S.; Kim H.; Kroon D.; Lippert P.C.; Loroch D.; Moebius I.; Moriya K.; Peppe D.J.; Ravizza G.E.; Röhl U.; Schueth J.D.; Sepúlveda J.; Sexton P.F.; Sibert E.C.; Śliwińska K.K.; Summons R.E.; Thomas E.; Westerhold T.; Whiteside J.H.; Yamaguchi T.; Zachos J.C.
收藏 | 浏览/下载：83/0 | 提交时间：2020/07/28
carbon dioxide carbon dioxide carbon cycle carbon dioxide Cretaceous-Paleogene boundary flood basalt global warming mass extinction paleotemperature volcanism Article astronomy basalt bolide boundary layer carbon cycle confusion (uncertainty) cosmological phenomena end Cretaceous mass extinction environmental impact environmental temperature greenhouse effect paleoenvironment Paleogene priority journal sea volcanic outgassing volcanism carbon cycle Mexico species extinction theoretical model volcano Carbon Cycle Carbon Dioxide Extinction, Biological Global Warming Mexico Models, Theoretical Volcanic Eruptions |
| Temperature-dependent sex determination is mediated by pSTAT3 repression of Kdm6b 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者: Weber C.; Zhou Y.; Lee J.G.; Looger L.L.; Qian G.; Ge C.; Capel B.
收藏 | 浏览/下载：40/0 | 提交时间：2020/07/28
STAT3 protein calcium histone demethylase STAT3 protein embryonic development gene expression sex determination temperature effect turtle animal cell animal experiment Article binding site calcium transport cell activation chromatin immunoprecipitation controlled study dimerization Dmrt1 gene embryo embryo development environmental temperature epigenetic repression female gene gene activation gene interaction gene targeting genetic transcription gonad high temperature immunofluorescence test Kdm6b gene male nonhuman priority journal protein phosphorylation real time polymerase chain reaction sex determination signal transduction temperature dependence thermoregulation transcription regulation upregulation Western blotting animal embryology gene expression regulation genetics metabolism phosphorylation sex determination process temperature turtle Reptilia Trachemys scripta Trachemys scripta elegans Animals Calcium Female Gene Expression Regulation, Developmental Jumonji Domain-Containing Histone Demethylases Male Phosphorylation Sex Determination Processes STAT3 Transcription Factor Temperature Transcription, Genetic Turtles |
| A dual light-driven palladium catalyst: Breaking the barriers in carbonylation reactions 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者: Torres G.M.; Liu Y.; Arndtsen B.A.
收藏 | 浏览/下载：38/0 | 提交时间：2020/07/28
amide carbon monoxide chloride electrophile ester ketone nucleophile palladium catalyst chemical bonding chemical reaction light effect palladium Article blue light carbonylation catalysis catalyst chemical reaction controlled study electron transport environmental temperature light light absorption oxidative addition photoreactivity priority journal reductive elimination room temperature |
| The hunger: Forecast 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者: Voosen P.
收藏 | 浏览/下载：273/0 | 提交时间：2020/07/28
hot water rain forecasting method gene expression literature review psychology Africa agricultural land agricultural management agronomy air temperature Article climate change coastal waters consumer Coronavirus infection crop production economic aspect economic development El Nino environmental monitoring environmental temperature Europe evaporation financial management flooding food assistance food handling food security government greenhouse effect human hunger Indian Ocean low income country Madagascar maize pandemic prediction priority journal public figure risk factor satellite imagery scientist seasonal variation soil moisture storm (weather) United States warming drought forecasting hunger theoretical model Africa, Eastern Droughts Famine Forecasting Models, Theoretical |
| Ultrahigh thermal conductivity in isotope-enriched cubic boron nitride 期刊论文
, 2020, 卷号: 367, 期号: 6477
作者: Chen K.; Song B.; Ravichandran N.K.; Zheng Q.; Chen X.; Lee H.; Sun H.; Li S.; Gamage G.A.G.U.; Tian F.; Ding Z.; Song Q.; Rai A.; Wu H.; Koirala P.; Schmidt A.J.; Watanabe K.; Lv B.; Ren Z.; Shi L.; Cahill D.G.; Taniguchi T.; Broido D.; Chen G.
收藏 | 浏览/下载：291/0 | 提交时间：2020/07/28
boron arsenide boron derivative boron phosphide cubic boron nitride isotope unclassified drug concentration (composition) inorganic compound temperature effect thermal conductivity Article phonon priority journal thermal conductivity ultrahigh thermal conductivity |
| Dopamine promotes cognitive effort by biasing the benefits versus costs of cognitive work 期刊论文
, 2020, 卷号: 367, 期号: 6484
作者: Westbrook A.; van den Bosch R.; Määttä J.I.; Hofmans L.; Papadopetraki D.; Cools R.; Frank M.J.
收藏 | 浏览/下载：60/0 | 提交时间：2020/07/28
dopamine dopamine 2 receptor methylphenidate sulpiride dopamine dopamine 2 receptor blocking agent dopamine uptake inhibitor brain cost-benefit analysis decision making hormone sampling adult Article cognition cost benefit analysis decision making dopamine metabolism female gaze human human experiment male memory consolidation motivation normal human priority journal receptor blocking striate cortex task performance adolescent biosynthesis caudate nucleus cognition corpus striatum drug effect eye fixation memory metabolism reward saccadic eye movement signal transduction young adult Adolescent Caudate Nucleus Choice Behavior Cognition Corpus Striatum Decision Making Dopamine Dopamine D2 Receptor Antagonists Dopamine Uptake Inhibitors Female Fixation, Ocular Humans Male Memory Methylphenidate Motivation Reward Saccades Signal Transduction Sulpiride Young Adult |
| Ratcheting quasi-ballistic electrons in silicon geometric diodes at room temperature 期刊论文
, 2020, 卷号: 368, 期号: 6487
作者: Custer J.P.; Jr.; Low J.D.; Hill D.J.; Teitsworth T.S.; Christesen J.D.; McKinney C.J.; McBride J.R.; Brooke M.A.; Warren S.C.; Cahoon J.F.
收藏 | 浏览/下载：48/0 | 提交时间：2020/07/28
aluminum oxide gold nanoparticle nanowire silicon data processing electron geometry silicon temperature effect analytic method Article data processing direct current electric capacitance electric current electron energy resource experimental test finite element analysis low temperature procedures mathematical model nanofabrication priority journal reaction time room temperature scanning electron microscopy scanning transmission electron microscopy signal processing three-dimensional imaging tilting |
