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Elesclomol alleviates Menkes pathology and mortality by escorting Cu to cuproenzymes in mice 期刊论文
, 2020, 卷号: 368, 期号: 6491
作者:  Guthrie L.M.;  Soma S.;  Yuan S.;  Silva A.;  Zulkifli M.;  Snavely T.C.;  Greene H.F.;  Nunez E.;  Lynch B.;  de Ville C.;  Shanbhag V.;  Lopez F.R.;  Acharya A.;  Petris M.J.;  Kim B.-E.;  Gohil V.M.;  Sacchettini J.C.
收藏  |  浏览/下载：37/0  |  提交时间：2020/07/28
copper  copper zinc superoxide dismutase  cytochrome c oxidase  dopamine beta monooxygenase  elesclomol  monophenol monooxygenase  protein lysine 6 oxidase  copper  cytochrome c oxidase  elesclomol  hydrazine derivative  copper  cytochrome  enzyme  enzyme activity  mitochondrion  mortality  mutation  pathology  rodent  survival  animal cell  animal experiment  animal model  animal tissue  Article  cohort analysis  controlled study  disease severity  drug mechanism  Golgi complex  H9c2(2-1) cell line  in vivo study  male  Menkes syndrome  mitochondrial dynamics  mortality rate  mouse  nerve degeneration  nonhuman  priority journal  secretory pathway  survival rate  animal  brain  cell line  degenerative disease  disease model  drug effect  genetics  knockout mouse  Menkes syndrome  metabolism  mitochondrion  pathology  rat  transport at the cellular level  Murinae  Mus  Animals  Biological Transport  Brain  Cell Line  Copper  Copper Transporter 1  Disease Models, Animal  Electron Transport Complex IV  Hydrazines  Male  Menkes Kinky Hair Syndrome  Mice  Mice, Knockout  Mitochondria  Neurodegenerative Diseases  Rats  
Natural hybridization reveals incompatible alleles that cause melanoma in swordtail fish 期刊论文
, 2020, 卷号: 368, 期号: 6492
作者:  Powell D.L.;  García-Olazábal M.;  Keegan M.;  Reilly P.;  Du K.;  Díaz-Loyo A.P.;  Banerjee S.;  Blakkan D.;  Reich D.;  Andolfatto P.;  Rosenthal G.G.;  Schartl M.;  Schumer M.
收藏  |  浏览/下载：37/0  |  提交时间：2020/07/28
allele  cyprinid  hybrid  hybridization  new species  reproductive status  skin disorder  survival  Vertebrata  fish protein  protein tyrosine kinase  Xmrk protein, Xiphophorus  allele  animal  chimera  Cyprinodontiformes  fin (organ)  fish disease  gene locus  genetics  genome-wide association study  hybridization  melanoma  pathology  virology  Alleles  Animal Fins  Animals  Chimera  Cyprinodontiformes  Fish Diseases  Fish Proteins  Genetic Loci  Genome-Wide Association Study  Hybridization, Genetic  Melanoma  Receptor Protein-Tyrosine Kinases  
Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model 期刊论文
, 2020, 卷号: 368, 期号: 6494
作者:  Rockx B.;  Kuiken T.;  Herfst S.;  Bestebroer T.;  Lamers M.M.;  Munnink B.B.O.;  De Meulder D.;  Van Amerongen G.;  Van Den Brand J.;  Okba N.M.A.;  Schipper D.;  Van Run P.;  Leijten L.;  Sikkema R.;  Verschoor E.;  Verstrepen B.;  Bogers W.;  Langermans J.;  Langermans J.;  Drosten C.;  Van Vlissingen M.F.;  Fouchier R.;  De Swart R.;  Koopmans M.;  Haagmans B.L.
收藏  |  浏览/下载：28/0  |  提交时间：2020/07/28
pathogenicity  pathology  primate  severe acute respiratory syndrome  viral disease  virus  Middle East  Coronavirus  Macaca  Primates  SARS coronavirus  aging  animal  Betacoronavirus  comparative study  Coronavirus infection  disease model  female  isolation and purification  lung  lung alveolus  Macaca fascicularis  Middle East respiratory syndrome coronavirus  pandemic  pathogenicity  pathology  physiology  respiratory system  SARS coronavirus  severe acute respiratory syndrome  virology  virus pneumonia  virus replication  virus shedding  Aging  Animals  Betacoronavirus  Coronavirus Infections  Disease Models, Animal  Female  Lung  Macaca fascicularis  Middle East Respiratory Syndrome Coronavirus  Pandemics  Pneumonia, Viral  Pulmonary Alveoli  Respiratory System  SARS Virus  Severe Acute Respiratory Syndrome  Virus Replication  Virus Shedding  
Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells 期刊论文
, 2020, 卷号: 368, 期号: 6494
作者:  Zhou Z.;  He H.;  Wang K.;  Shi X.;  Wang Y.;  Su Y.;  Wang Y.;  Li D.;  Liu W.;  Zhang Y.;  Shen L.;  Han W.;  Shen L.;  Ding J.;  Shao F.
收藏  |  浏览/下载：43/0  |  提交时间：2020/07/28
cell  cell component  cytology  enzyme  enzyme activity  gene expression  immunity  tumor  Mus  gamma interferon  granzyme  GSDMB protein, human  GZMA protein, human  pore forming cytotoxic protein  tumor protein  animal  Bagg albino mouse  chemistry  cytotoxic T lymphocyte  enzymology  genetics  HEK293 cell line  human  immunology  metabolism  mouse  natural killer cell  neoplasm  pathology  protein degradation  protein domain  pyroptosis  transgenic mouse  Animals  Granzymes  HEK293 Cells  Humans  Interferon-gamma  Killer Cells, Natural  Mice  Mice, Inbred BALB C  Mice, Transgenic  Neoplasm Proteins  Neoplasms  Pore Forming Cytotoxic Proteins  Protein Domains  Proteolysis  Pyroptosis  T-Lymphocytes, Cytotoxic  
Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis 期刊论文
, 2020, 卷号: 367, 期号: 6485
作者:  Ebright R.Y.;  Lee S.;  Wittner B.S.;  Niederhoffer K.L.;  Nicholson B.T.;  Bardia A.;  Truesdell S.;  Wiley D.F.;  Wesley B.;  Li S.;  Mai A.;  Aceto N.;  Vincent-Jordan N.;  Szabolcs A.;  Chirn B.;  Kreuzer J.;  Comaills V.;  Kalinich M.;  Haas W.;  Ting D.T.;  Toner M.;  Vasudevan S.;  Haber D.A.;  Maheswaran S.;  Micalizzi D.S.
收藏  |  浏览/下载：56/0  |  提交时间：2020/07/28
CRISPR associated protein  epidermal growth factor receptor 2  Ki 67 antigen  ribosome protein  ribosome RNA  transcription factor E2F  ribosome protein  cancer  cell  gene expression  genetic engineering  protein  RNA  tumor  animal experiment  animal model  animal tissue  Article  biogenesis  bioluminescence  breast cancer  cell cycle progression  cell cycle regulation  cell proliferation  circulating tumor cell  controlled study  enzyme activation  epithelial mesenchymal transition  gene expression profiling  genetic transcription  human  human cell  lung metastasis  metastasis  microfluidics  mouse  nonhuman  overall survival  phenotype  priority journal  progression free survival  promoter region  protein expression  protein processing  protein synthesis  proteomics  RNA sequence  transcription regulation  animal  breast tumor  cancer transplantation  CRISPR Cas system  female  gene expression regulation  genetics  pathology  sequence analysis  tumor cell line  tumor embolism  Mus  Animals  Breast Neoplasms  Cell Line, Tumor  CRISPR-Cas Systems  Female  Gene Expression Regulation, Neoplastic  Humans  Mice  Neoplasm Metastasis  Neoplasm Transplantation  Neoplastic Cells, Circulating  Ribosomal Proteins  Sequence Analysis, RNA  
Developing a point process model for ecological risk assessment of pine wilt disease at multiple scales 期刊论文
, 2020, 卷号: 463
作者:  Matsuhashi S.;  Hirata A.;  Akiba M.;  Nakamura K.;  Oguro M.;  Takano K.T.;  Nakao K.;  Hijioka Y.;  Matsui T.
收藏  |  浏览/下载：23/0  |  提交时间：2020/07/28
Climate change  Compensation (personnel)  Forestry  Maps  Pest control  Poisson distribution  Biological invasion  Ecological risk assessment  General circulation model  Mean annual temperatures  Poisson regression  Risk maps  Species distribution models  Sustainable forest management  Risk assessment  biological invasion  coniferous tree  disease incidence  environmental risk  forest management  pathology  spatial distribution  wilt  Data  Forestry  Maps  Pest Control  Pinus  Processes  Risk Assessment  Sustainable Forest Management  Japan  Coniferophyta  
A rampage through the body 期刊论文
, 2020, 卷号: 368, 期号: 6489
作者:  Wadman M.;  Couzin-Frankel J.;  Kaiser J.;  Matacic C.
收藏  |  浏览/下载：33/0  |  提交时间：2020/07/28
blood  brain  brain drain  cell organelle  immune response  infectious disease  protein  viral disease  Article  clinical feature  coronavirus disease 2019  disease severity  disease transmission  human  mortality rate  patient care  patient risk  priority journal  risk factor  Betacoronavirus  blood vessel  brain  Coronavirus infection  female  lung  male  middle aged  multiple organ failure  pandemic  pathogenicity  pathology  virology  virus entry  virus pneumonia  Betacoronavirus  Blood Vessels  Brain  Coronavirus Infections  Female  Humans  Lung  Male  Middle Aged  Multiple Organ Failure  Pandemics  Pneumonia, Viral  Virus Internalization  
Amplifying plant disease risk through assisted migration 期刊论文
CONSERVATION LETTERS, 2019, 卷号: 12, 期号: 2
作者:  Simler, Allison B.;  Williamson, Matthew A.;  Schwartz, Mark W.;  Rizzo, David M.
收藏  |  浏览/下载：28/0  |  提交时间：2019/10/08
adaptation policy  climate adaptation  climate change  endangered species  plant pathology  species translocation  
Impact of Cesium on Plants and the Environment 专著
:Springer International Publishing, Springer, 2017
作者:  Gupta Dharmendra K;  Walther Clemens
收藏  |  浏览/下载：23/0  |  提交时间：2020/03/25
Environment.  Nuclear energy.  Plant pathology.  Environmental monitoring.  Environmental management.  Environment.  Monitoring/Environmental Analysis.  Environmental Management.  Nuclear Energy.  Plant Pathology.