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Therapeutic targeting of preleukemia cells in a mouse model of NPM1 mutant acute myeloid leukemia 期刊论文
, 2020, 卷号: 367, 期号: 6477
作者:  Uckelmann H.J.;  Kim S.M.;  Wong E.M.;  Hatton C.;  Giovinazzo H.;  Gadrey J.Y.;  Krivtsov A.V.;  Rücker F.G.;  Döhner K.;  McGeehan G.M.;  Levine R.L.;  Bullinger L.;  Vassiliou G.S.;  Armstrong S.A.
收藏  |  浏览/下载：37/0  |  提交时间：2020/07/28
antileukemic agent  methionine  unclassified drug  vtp 50469  biological development  cancer  cell  disease treatment  mutation  numerical model  oral health  acute myeloid leukemia  animal cell  animal experiment  animal model  antineoplastic activity  Article  cell proliferation  cell self-renewal  chromatin  controlled study  drug targeting  gene  gene mutation  leukemia cell  molecularly targeted therapy  mouse  mouse model  nonhuman  NPM1 gene  preleukemia  priority journal  Mus  
The evolutionary dynamics and fitness landscape of clonal hematopoiesis 期刊论文
, 2020, 卷号: 367, 期号: 6485
作者:  Watson C.J.;  Papula A.L.;  Poon G.Y.P.;  Wong W.H.;  Young A.L.;  Druley T.E.;  Fisher D.S.;  Blundell J.R.
收藏  |  浏览/下载：46/0  |  提交时间：2020/07/28
DNA methyltransferase 3A  blood  cancer  evolutionary biology  fitness  gene expression  genetic drift  hematology  mutation  pathogenicity  acute myeloid leukemia  age distribution  allele  Article  cancer risk  cell expansion  cell population  clonal hematopoiesis  epigenetics  gene mutation  genetic variability  hematological parameters  hematopoiesis  hematopoietic stem cell  human  molecular evolution  mutational analysis  nonhuman  priority journal  single nucleotide polymorphism  somatic mutation  stem cell self-renewal  
Maintenance of neural stem cell positional identity by mixed-lineage leukemia 1 期刊论文
, 2020, 卷号: 368, 期号: 6486
作者:  Delgado R.N.;  Mansky B.;  Ahanger S.H.;  Lu C.;  Andersen R.E.;  Dou Y.;  Alvarez-Buylla A.;  Lim D.A.
收藏  |  浏览/下载：30/0  |  提交时间：2020/07/28
mixed lineage leukemia 1 protein  mixed lineage leukemia protein  morphogen  sonic hedgehog protein  unclassified drug  anatomy  brain  cell component  developmental biology  inhibition  adult  animal cell  animal experiment  animal tissue  Article  controlled study  embryo  epigenetics  forebrain  in vivo study  memory  Mll1 gene  mouse  nerve cell  nerve cell differentiation  neural stem cell  nonhuman  priority journal  Erinaceidae  Murinae  
Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation 期刊论文
, 2020, 卷号: 368, 期号: 6489
作者:  Gilan O.;  Rioja I.;  Knezevic K.;  Bell M.J.;  Yeung M.M.;  Harker N.R.;  Lam E.Y.N.;  Chung C.;  Bamborough P.;  Petretich M.;  Urh M.;  Atkinson S.J.;  Bassil A.K.;  Roberts E.J.;  Vassiliadis D.;  Burr M.L.;  Preston A.G.S.;  Wellaway C.;  Werner T.;  Gray J.R.;  Michon A.-M.;  Gobbetti T.;  Kumar V.;  Soden P.E.;  Haynes A.;  Vappiani J.;  Tough D.F.;  Taylor S.;  Dawson S.-J.;  Bantscheff M.;  Lindon M.;  Drewes G.;  Demont E.H.;  Daniels D.L.;  Grandi P.;  Prinjha R.K.;  Dawson M.A.
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7 (3,5 dimethyl 4 isoxazolyl) 1,3 dihydro 8 methoxy 1 [1 (2 pyridinyl)ethyl] 2h imidazo[4,5 c]quinolin 2 one  apremilast  bromodomain and extraterminal domain protein 1  bromodomain and extraterminal domain protein 2  bromodomain inhibitor  gsk 046  gsk 620  gsk 778  transcription factor  unclassified drug  cancer  drug  gene expression  immune response  inhibitor  physiological response  acute myeloid leukemia  animal experiment  animal model  animal tissue  antibody response  antineoplastic activity  antiproliferative activity  apoptosis  Article  binding affinity  controlled study  crystal structure  drug design  drug efficacy  drug protein binding  drug selectivity  drug specificity  drug structure  drug targeting  gene expression  high throughput screening  human  human cell  IC50  immunomodulation  in vivo study  inflammation  K-562 cell line  malignant neoplasm  MDA-MB-453 cell line  MOLM-13 cell line  mouse  nonhuman  priority journal  psoriasis