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HEM1 deficiency disrupts mTORC2 and F-actin control in inherited immunodysregulatory disease 期刊论文
, 2020, 卷号: 369, 期号: 6500
作者:  Cook S.A.;  Comrie W.A.;  Poli M.C.;  Similuk M.;  Oler A.J.;  Faruqi A.J.;  Kuhns D.B.;  Yang S.;  Vargas-Hernández A.;  Carisey A.F.;  Fournier B.;  Anderson D.E.;  Price S.;  Smelkinson M.;  Abou Chahla W.;  Forbes L.R.;  Mace E.M.;  Cao T.N.;  Coban-Akdemir Z.H.;  Jhangiani S.N.;  Muzny D.M.;  Gibbs R.A.;  Lupski J.R.;  Orange J.S.;  Cuvelier G.D.E.;  Al Hassani M.;  Al Kaabi N.;  Al Yafei Z.;  Jyonouchi S.;  Raje N.;  Caldwell J.W.;  Huang Y.;  Burkhardt J.K.;  Latour S.;  Chen B.;  ElGhazali G.;  Rao V.K.;  Chinn I.K.;  Lenardo M.J.
收藏  |  浏览/下载：46/0  |  提交时间：2020/07/28
actin  adenosine diphosphate ribosylation factor 1  ARF1 protein, human  cytokine  mammalian target of rapamycin complex 2  membrane protein  NCKAP1L protein, human  WASF1 protein, human  WASF2 protein, human  WASF3 protein, human  Wiskott Aldrich syndrome protein  biosynthesis  CD4+ T lymphocyte  cell proliferation  chemistry  genetics  human  immune deficiency  immunology  lymphoproliferative disease  metabolism  pedigree  phosphorylation  physiology  Actins  ADP-Ribosylation Factor 1  CD4-Positive T-Lymphocytes  Cell Proliferation  Cytokines  Humans  Immunologic Deficiency Syndromes  Lymphoproliferative Disorders  Mechanistic Target of Rapamycin Complex 2  Membrane Proteins  Pedigree  Phosphorylation  Wiskott-Aldrich Syndrome Protein Family  
Evolving epidemiology of poliovirus serotype 2 following withdrawal of the serotype 2 oral poliovirus vaccine 期刊论文
, 2020, 卷号: 368, 期号: 6489
作者:  Macklin G.R.;  O’Reilly K.M.;  Grassly N.C.;  Edmunds W.J.;  Mach O.;  Santhana Gopala Krishnan R.;  Voorman A.;  Vertefeuille J.F.;  Abdelwahab J.;  Gumede N.;  Goel A.;  Sosler S.;  Sever J.;  Bandyopadhyay A.S.;  Pallansch M.A.;  Nandy R.;  Mkanda P.;  Diop O.M.;  Sutter R.W.
收藏  |  浏览/下载：40/0  |  提交时间：2020/07/28
poliomyelitis vaccine  oral poliomyelitis vaccine  disease transmission  epidemiology  immunity  vaccine  virus  acute flaccid paralysis  Article  disease control  disease eradication  flaccid paralysis  geography  health care policy  human  Human poliovirus 2  immune deficiency  immunization  incidence  intestinal mucosal immunity  logistic regression analysis  mucosal immunity  priority journal  public health campaign  sanitation  statistical model  treatment withdrawal  virus transmission  epidemic  global health  immunology  poliomyelitis  Poliomyelitis virus  procedures  treatment withdrawal  Poliovirus  Disease Eradication  Disease Outbreaks  Global Health  Humans  Poliomyelitis  Poliovirus  Poliovirus Vaccine, Oral  Withholding Treatment  
Cultivating fungal research 期刊论文
, 2020, 卷号: 368, 期号: 6489
作者:  Kong H.H.;  Segre J.A.
收藏  |  浏览/下载：62/0  |  提交时间：2020/07/28
amphotericin B  dectin 1  echinocandin  fluconazole  interleukin 17  bacterium  fungal disease  fungus  immune system  mutualism  pathogen  antifungal resistance  Article  autoimmune disease  bloodstream infection  Candida albicans  Candida auris  CD4+ T lymphocyte  commensalism  fungal colonization  fungus transmission  host fungus interaction  immune deficiency  interferon production  multidrug resistance  mycosis  nonhuman  opportunistic infection  pancreas adenocarcinoma  priority journal  Th17 cell  
Structure of CD20 in complex with the therapeutic monoclonal antibody rituximab 期刊论文
, 2020, 卷号: 367, 期号: 6483
作者:  Rougé L.;  Chiang N.;  Steffek M.;  Kugel C.;  Croll T.I.;  Tam C.;  Estevez A.;  Arthur C.P.;  Koth C.M.;  Ciferri C.;  Kraft E.;  Payandeh J.;  Nakamura G.;  Koerber J.T.;  Rohou A.
收藏  |  浏览/下载：19/0  |  提交时间：2020/07/28
CD20 antigen  dimer  epitope  Fc receptor  immunoglobulin F(ab) fragment  obinutuzumab  ocrelizumab  ofatumumab  rituximab  tositumomab i 131  antibody  antigen  cell  chemical binding  composite  gene expression  genetic marker  protein  amino acid sequence  antibody dependent cellular cytotoxicity  antigen antibody complex  antigen binding  antigen structure  Article  cell death  cell surface  chemical bond  complement dependent cytotoxicity  drug protein binding  drug targeting  electron microscopy  human  humoral immune deficiency  insect cell  lipid raft  malignant neoplasm  molecular recognition  multiple sclerosis  nonhuman  phagocytosis  priority journal  protein cross linking  protein interaction  stoichiometry  surface plasmon resonance  
Structural basis of second-generation HIV integrase inhibitor action and viral resistance 期刊论文
, 2020, 卷号: 367, 期号: 6479
作者:  Cook N.J.;  Li W.;  Berta D.;  Badaoui M.;  Ballandras-Colas A.;  Nans A.;  Kotecha A.;  Rosta E.;  Engelman A.N.;  Cherepanov P.
收藏  |  浏览/下载：30/0  |  提交时间：2020/07/28
bictegravir  dolutegravir  lens epithelium derived growth factor  magnesium ion  bictegravir  dolutegravir  fused heterocyclic rings  glutamine  glycine  histidine  integrase  integrase inhibitor  magnesium  serine  acquired immune deficiency syndrome  amino acid  drug  human immunodeficiency virus  inhibitor  protein  ultrastructure  virus  amino acid substitution  amino terminal sequence  Article  carboxy terminal sequence  cryoelectron microscopy  DNA binding  drug design  drug protein binding  drug structure  enzyme active site  gene mutation  Human immunodeficiency virus 1  in vitro study  molecular dynamics  molecular stability  nonhuman  pharmacophore  polarization  priority journal  protonation  virus resistance  antiviral resistance  chemistry  genetics  human  mutation  procedures  single molecule imaging  Amino Acid Substitution  Catalytic Domain  Cryoelectron Microscopy  Drug Resistance, Viral  Glutamine  Glycine  Heterocyclic Compounds, 3-Ring  Heterocyclic Compounds, 4 or More Rings  Histidine  HIV Integrase  HIV Integrase Inhibitors  Humans  Magnesium  Mutation  Serine  Single Molecule Imaging