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Modeling the historical distribution of American chestnut (Castanea dentata) for potential restoration in western New York State, US 期刊论文
, 2020, 卷号: 462
作者:  Tulowiecki S.J.
收藏  |  浏览/下载：41/0  |  提交时间：2020/07/28
Genetic engineering  Geographical distribution  Image reconstruction  Population distribution  Restoration  American chestnut  Castanea dentata  Gap analysis  Presettlement  Species distribution models  Fruits  genetic engineering  landownership  nongovernmental organization  population distribution  reintroduction  restoration ecology  terrain  Castanea  Distribution  Fruits  Genetic Engineering  Land Survey  Research  Restoration  New York  York  Castanea dentata  Fungi  
Structure and selectivity engineering of the M1 muscarinic receptor toxin complex 期刊论文
, 2020, 卷号: 369, 期号: 6500
作者:  Maeda S.;  Xu J.;  N Kadji F.M.;  Clark M.J.;  Zhao J.;  Tsutsumi N.;  Aoki J.;  Sunahara R.K.;  Inoue A.;  Garcia K.C.;  Kobilka B.K.
收藏  |  浏览/下载：53/0  |  提交时间：2020/07/28
atropine  m1-toxin  muscarinic M1 receptor  muscarinic receptor blocking agent  snake venom  animal  chemistry  genetic engineering  genetics  protein conformation  Sf9 cell line  X ray crystallography  Animals  Atropine  Crystallography, X-Ray  Elapid Venoms  Genetic Engineering  Muscarinic Antagonists  Protein Conformation  Receptor, Muscarinic M1  Sf9 Cells  
Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者:  Walton R.T.;  Christie K.A.;  Whittaker M.N.;  Kleinstiver B.P.
收藏  |  浏览/下载：27/0  |  提交时间：2020/07/28
adenine  adenosine  CRISPR associated endonuclease Cas9  cytosine  guanosine  SpG protein  SpRY nuclease  thymine  unclassified drug  Cas9 endonuclease Streptococcus pyogenes  bacterium  enzyme activity  genetic engineering  genetic variation  genome  Article  CRISPR-CAS9 system  DNA sequence  enzyme activity  gene editing  gene targeting  genetic variability  human  mutagenesis  nonhuman  priority journal  protein engineering  protein motif  protein structure  protospacer adjacent motif  Streptococcus pyogenes  chemistry  CRISPR Cas system  enzyme specificity  gene editing  gene targeting  genetic predisposition  genetics  HEK293 cell line  procedures  protein domain  Streptococcus pyogenes  CRISPR-Associated Protein 9  CRISPR-Cas Systems  Gene Editing  Gene Targeting  Genetic Predisposition to Disease  HEK293 Cells  Humans  Mutagenesis  Protein Domains  Substrate Specificity  
Electrogenetic cellular insulin release for real-time glycemic control in type 1 diabetic mice 期刊论文
, 2020, 卷号: 368, 期号: 6494
作者:  Krawczyk K.;  Xue S.;  Buchmann P.;  Charpin-El-Hamri G.;  Saxena P.;  Hussherr M.-D.;  Shao J.;  Ye H.;  Xie M.;  Fussenegger M.
收藏  |  浏览/下载：38/0  |  提交时间：2020/07/28
cell  diabetes  hormone  peptide  real time  rodent  Mus  calcium channel L type  inwardly rectifying potassium channel  inwardly rectifying potassium channel subunit Kir2.1  L-type calcium channel alpha(1C)  animal  calcium signaling  cell engineering  devices  electrostimulation  experimental diabetes mellitus  genetic transcription  genetics  HEK293 cell line  human  insulin dependent diabetes mellitus  insulin release  male  metabolism  mouse  pancreas islet beta cell  prostheses and orthoses  transgene  wireless communication  Animals  Bionics  Calcium Channels, L-Type  Calcium Signaling  Cell Engineering  Diabetes Mellitus, Experimental  Diabetes Mellitus, Type 1  Electric Stimulation  HEK293 Cells  Humans  Insulin Secretion  Insulin-Secreting Cells  Male  Mice  Potassium Channels, Inwardly Rectifying  Prostheses and Implants  Transcription, Genetic  Transgenes  Wireless Technology  
Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis 期刊论文
, 2020, 卷号: 367, 期号: 6485
作者:  Ebright R.Y.;  Lee S.;  Wittner B.S.;  Niederhoffer K.L.;  Nicholson B.T.;  Bardia A.;  Truesdell S.;  Wiley D.F.;  Wesley B.;  Li S.;  Mai A.;  Aceto N.;  Vincent-Jordan N.;  Szabolcs A.;  Chirn B.;  Kreuzer J.;  Comaills V.;  Kalinich M.;  Haas W.;  Ting D.T.;  Toner M.;  Vasudevan S.;  Haber D.A.;  Maheswaran S.;  Micalizzi D.S.
收藏  |  浏览/下载：54/0  |  提交时间：2020/07/28
CRISPR associated protein  epidermal growth factor receptor 2  Ki 67 antigen  ribosome protein  ribosome RNA  transcription factor E2F  ribosome protein  cancer  cell  gene expression  genetic engineering  protein  RNA  tumor  animal experiment  animal model  animal tissue  Article  biogenesis  bioluminescence  breast cancer  cell cycle progression  cell cycle regulation  cell proliferation  circulating tumor cell  controlled study  enzyme activation  epithelial mesenchymal transition  gene expression profiling  genetic transcription  human  human cell  lung metastasis  metastasis  microfluidics  mouse  nonhuman  overall survival  phenotype  priority journal  progression free survival  promoter region  protein expression  protein processing  protein synthesis  proteomics  RNA sequence  transcription regulation  animal  breast tumor  cancer transplantation  CRISPR Cas system  female  gene expression regulation  genetics  pathology  sequence analysis  tumor cell line  tumor embolism  Mus  Animals  Breast Neoplasms  Cell Line, Tumor  CRISPR-Cas Systems  Female  Gene Expression Regulation, Neoplastic  Humans  Mice  Neoplasm Metastasis  Neoplasm Transplantation  Neoplastic Cells, Circulating  Ribosomal Proteins  Sequence Analysis, RNA  
CRISPR-engineered T cells in patients with refractory cancer 期刊论文
, 2020, 卷号: 367, 期号: 6481
作者:  Stadtmauer E.A.;  Fraietta J.A.;  Davis M.M.;  Cohen A.D.;  Weber K.L.;  Lancaster E.;  Mangan P.A.;  Kulikovskaya I.;  Gupta M.;  Chen F.;  Tian L.;  Gonzalez V.E.;  Xu J.;  Jung I.-Y.;  Joseph Melenhorst J.;  Plesa G.;  Shea J.;  Matlawski T.;  Cervini A.;  Gaymon A.L.;  Desjardins S.;  Lamontagne A.;  Salas-Mckee J.;  Fesnak A.;  Siegel D.L.;  Levine B.L.;  Jadlowsky J.K.;  Young R.M.;  Chew A.;  Hwang W.-T.;  Hexner E.O.;  Carreno B.M.;  Nobles C.L.;  Bushman F.D.;  Parker K.R.;  Qi Y.;  Satpathy A.T.;  Chang H.Y.;  Zhao Y.;  Lacey S.F.;  June C.H.
收藏  |  浏览/下载：43/0  |  提交时间：2020/07/28
heterodimer  programmed death 1 receptor  T lymphocyte receptor alpha chain  T lymphocyte receptor beta chain  cancer  cell  gene  gene expression  genetic engineering  immunity  protein  adult  aged  Article  cancer patient  cell engineering  chromosome translocation  clinical article  clustered regularly interspaced short palindromic repeat  controlled study  CRISPR-CAS9 system  feasibility study  female  gene editing  gene expression  gene frequency  gene locus  genetic code  human  human cell  male  middle aged  myeloma  PDCD1 gene  phase 1 clinical trial  priority journal  sarcoma  T lymphocyte  TRAC gene  TRBC gene  tumor immunity  
De novo design of protein logic gates 期刊论文
, 2020, 卷号: 368, 期号: 6486
作者:  Chen Z.;  Kibler R.D.;  Hunt A.;  Busch F.;  Pearl J.;  Jia M.;  VanAernum Z.L.;  Wicky B.I.M.;  Dods G.;  Liao H.;  Wilken M.S.;  Ciarlo C.;  Green S.;  El-Samad H.;  Stamatoyannopoulos J.;  Wysocki V.H.;  Jewett M.C.;  Boyken S.E.;  Baker D.
收藏  |  浏览/下载：30/0  |  提交时间：2020/07/28
cell  design method  gene expression  genetic analysis  protein  activation domain  Article  binding affinity  circular dichroism  controlled study  de novo design  design  DNA binding motif  enzyme activity  genetic transcription  human  human cell  hydrogen bond  hydrophobicity  mass spectrometry  native mass spectrometry  nonhuman  priority journal  protein protein interaction  protein structure  RNA translation  stoichiometry  thermodynamics  two hybrid system  X ray crystallography  chemistry  genetics  logic  metabolism  protein analysis  protein engineering  protein processing  synthetic biology  T lymphocyte  yeast  HAVCR2 protein, human  hepatitis A virus cellular receptor 2  Hepatitis A Virus Cellular Receptor 2  Humans  Logic  Mass Spectrometry  Protein Engineering  Protein Interaction Maps  Protein Processing, Post-Translational  Synthetic Biology  T-Lymphocytes  Transcription, Genetic  Yeasts  
Susceptibility of mountain pine beetle (Dendroctonus ponderosae Hopkins) to gene silencing through RNAi provides potential as a novel management tool 期刊论文
, 2020, 卷号: 473
作者:  Kyre B.R.;  Bentz B.J.;  Rieske L.K.
收藏  |  浏览/下载：188/0  |  提交时间：2020/07/28
Agricultural robots  Expansion  Gene expression  Genetic engineering  Polymerase chain reaction  Dendroctonus ponderosae  Environmental contamination  Expression analysis  Mountain pine beetle  Quantitative real time PCR  Sex-specific differences  Southern pine beetle  Technology progress  Forestry  beetle  climate change  coniferous forest  crop pest  endemic species  gene expression  pest species  range expansion  RNA  Expansion  Forestry  Genes  Genetic Engineering  Insects  Management  Mortality  Pinus Mugo  North America  Coleoptera  Coniferophyta  Dendroctonus frontalis  Dendroctonus ponderosae  Hexapoda  Pinus mugo  
Engineered symbionts activate honey bee immunity and limit pathogens 期刊论文
, 2020, 卷号: 367, 期号: 6477
作者:  Leonard S.P.;  Powell J.E.;  Perutka J.;  Geng P.;  Heckmann L.C.;  Horak R.D.;  Davies B.W.;  Ellington A.D.;  Barrick J.E.;  Moran N.A.
收藏  |  浏览/下载：18/0  |  提交时间：2020/07/28
double stranded RNA  bacterium  engineering  honeybee  host-pathogen interaction  immune response  immunity  pathogen  symbiont  Article  bacterial colonization  controlled study  gene expression  gene repression  genetic engineering  honeybee  immunity  intestine flora  nonhuman  priority journal  RNA interference  Snodgrassella alvi  symbiont  Varroa  animal  bee  genetic engineering  genetics  immunology  microbiology  Neisseriaceae  physiology  symbiosis  Varroidae  Acari  Apis mellifera  Apoidea  Bacteria (microorganisms)  Eukaryota  Varroa  Animals  Bees  Gastrointestinal Microbiome  Genetic Engineering  Neisseriaceae  RNA Interference  Symbiosis  Varroidae  
Enhanced sustainable green revolution yield via nitrogen-responsive chromatin modulation in rice 期刊论文
, 2020, 卷号: 367, 期号: 6478
作者:  Wu K.;  Wang S.;  Song W.;  Zhang J.;  Wang Y.;  Liu Q.;  Yu J.;  Ye Y.;  Li S.;  Chen J.;  Zhao Y.;  Wang J.;  Wu X.;  Wang M.;  Zhang Y.;  Liu B.;  Wu Y.;  Harberd N.P.;  Fu X.
收藏  |  浏览/下载：43/0  |  提交时间：2020/07/28
DELLA protein  gibberellin  gibberellin insensitive dwarf1  histone H3  polycomb repressive complex 2  receptor  transcription factor  unclassified drug  alternative agriculture  chromosome  gene expression  genetic engineering  green revolution  inhibition  molecular analysis  nitrogen  nutrient use efficiency  protein  rice  agriculture  allele  Article  chromatin immunoprecipitation  controlled study  D14 gene  gene mutation  genetic screening  genetic transcription  grain yield  green revolution  histone modification  modulation  ngr5 gene  nitrogen availability  nitrogen responsive chromatin modulation  nonhuman  OsSPL14 gene  plant gene  polymerase chain reaction  priority journal  protein protein interaction  rice  RNA sequencing  varietas