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| Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations 期刊论文
, 2020, 卷号: 367, 期号: 6478
作者: Wilmes S.; Hafer M.; Vuorio J.; Tucker J.A.; Winkelmann H.; Löchte S.; Stanly T.A.; Pulgar Prieto K.D.; Poojari C.; Sharma V.; Richter C.P.; Kurre R.; Hubbard S.R.; Christopher Garcia K.; Moraga I.; Vattulainen I.; Hitchcock I.S.; Piehler J.
  收藏 | 浏览/下载：48/0 | 提交时间：2020/07/28
cytokine receptor homodimer Janus kinase 2 ligand oncoprotein cancer enzyme enzyme activity membrane molecular analysis mutation protein activation analysis Article cell membrane computer model controlled study dimerization fluorescence microscopy gene mutation HeLa cell line molecular dynamics mutant oncogene priority journal protein domain protein interaction quantitative analysis signal transduction |
| Computing cancer's weak spots 期刊论文
, 2020, 卷号: 368, 期号: 6496
作者: Khamsi R.
收藏 | 浏览/下载：47/0 | 提交时间：2020/07/28
ruxolitinib STAT3 protein antineoplastic agent transcription factor algorithm cancer computer simulation disease treatment drug development medicine Article cancer cell cancer radiotherapy enzyme inhibition gene activity gene expression regulation gene interaction gene mutation gene repression gene targeting human laboratory test malignant neoplasm molecular dynamics nonhuman oncologist priority journal RNA sequencing algorithm genetics mutation neoplasm personalized medicine procedures systems biology Algorithms Antineoplastic Agents Humans Mutation Neoplasms Precision Medicine Systems Biology Transcription Factors |
| PE/PPE proteins mediate nutrient transport across the outer membrane of Mycobacterium tuberculosis 期刊论文
, 2020, 卷号: 367, 期号: 6482
作者: Wang Q.; Boshoff H.I.M.; Harrison J.R.; Ray P.C.; Green S.R.; Wyatt P.G.; Barry Iii C.E.
收藏 | 浏览/下载：28/0 | 提交时间：2020/07/28
3,3 bis di(methylsulfonyl)propionamide antiinfective agent bacterial protein glucose glycerol magnesium phosphate propionamide derivative protein proline proline glutamate protein proline proline glutamate 51 unclassified drug amide bacterial protein lipid phthiocerol dimycocerosate propionamide thiol derivative cell component chemical compound membrane mutation protein tuberculosis antibiotic resistance Article bacterial cell bacterial cell wall bacterial growth bacterial outer membrane cell division drug structure Mycobacterium tuberculosis nonhuman nutrient uptake priority journal protein depletion cell membrane cell membrane permeability chemistry drug effect gene deletion genetics metabolism transport at the cellular level Mycobacterium tuberculosis Amides Bacterial Proteins Biological Transport Cell Membrane Cell Membrane Permeability Drug Resistance, Bacterial Gene Deletion Glucose Glycerol Lipids Mycobacterium tuberculosis Sulfhydryl Compounds |
| Therapeutic targeting of preleukemia cells in a mouse model of NPM1 mutant acute myeloid leukemia 期刊论文
, 2020, 卷号: 367, 期号: 6477
作者: Uckelmann H.J.; Kim S.M.; Wong E.M.; Hatton C.; Giovinazzo H.; Gadrey J.Y.; Krivtsov A.V.; Rücker F.G.; Döhner K.; McGeehan G.M.; Levine R.L.; Bullinger L.; Vassiliou G.S.; Armstrong S.A.
收藏 | 浏览/下载：36/0 | 提交时间：2020/07/28
antileukemic agent methionine unclassified drug vtp 50469 biological development cancer cell disease treatment mutation numerical model oral health acute myeloid leukemia animal cell animal experiment animal model antineoplastic activity Article cell proliferation cell self-renewal chromatin controlled study drug targeting gene gene mutation leukemia cell molecularly targeted therapy mouse mouse model nonhuman NPM1 gene preleukemia priority journal Mus |
| Mechanisms generating cancer genome complexity from a single cell division error 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者: Umbreit N.T.; Zhang C.-Z.; Lynch L.D.; Blaine L.J.; Cheng A.M.; Tourdot R.; Sun L.; Almubarak H.F.; Judge K.; Mitchell T.J.; Spektor A.; Pellman D.
收藏 | 浏览/下载：15/0 | 提交时间：2020/07/28
myosin adenosine triphosphatase cancer chromosome detection method DNA error correction gene expression genome genomics mutation Article cell division cellular, subcellular and molecular biological phenomena and functions chromosome breakage chromosome breakage fusion bridge chromosome bridge formation chromosomes and chromosomal phenomena chromothripsis DNA damage DNA replication human interphase malignant neoplasm micronucleus mitosis oncogenomics priority journal single cell division error |
| The evolutionary dynamics and fitness landscape of clonal hematopoiesis 期刊论文
, 2020, 卷号: 367, 期号: 6485
作者: Watson C.J.; Papula A.L.; Poon G.Y.P.; Wong W.H.; Young A.L.; Druley T.E.; Fisher D.S.; Blundell J.R.
收藏 | 浏览/下载：40/0 | 提交时间：2020/07/28
DNA methyltransferase 3A blood cancer evolutionary biology fitness gene expression genetic drift hematology mutation pathogenicity acute myeloid leukemia age distribution allele Article cancer risk cell expansion cell population clonal hematopoiesis epigenetics gene mutation genetic variability hematological parameters hematopoiesis hematopoietic stem cell human molecular evolution mutational analysis nonhuman priority journal single nucleotide polymorphism somatic mutation stem cell self-renewal |
| Structure of nucleosome-bound human BAF complex 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者: He S.; Wu Z.; Tian Y.; Yu Z.; Yu J.; Wang X.; Li J.; Liu B.; Xu Y.
收藏 | 浏览/下载：38/0 | 提交时间：2020/07/28
actin related protein adenosine triphosphatase BRG1 BRM associated factor DNA multiprotein complex protein SWI retinoblastoma binding protein 2 SMARCC protein SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily B member 1 transcription factor transcription factor SNF unclassified drug cancer enzyme activity gene expression hydrolysis mutation protein alpha helix Article carboxy terminal sequence cell interaction cryoelectron microscopy disease association human malignant neoplasm molecular recognition mutation nucleosome priority journal protein function protein hydrolysis protein structure structure analysis Mammalia |
| A Kelch13-defined endocytosis pathway mediates artemisinin resistance in malaria parasites 期刊论文
, 2020, 卷号: 367, 期号: 6473
作者: Birnbaum J.; Scharf S.; Schmidt S.; Jonscher E.; Maria Hoeijmakers W.A.; Flemming S.; Toenhake C.G.; Schmitt M.; Sabitzki R.; Bergmann B.; Fröhlke U.; Mesén-Ramírez P.; Soares A.B.; Herrmann H.; Bártfai R.; Spielmann T.
收藏 | 浏览/下载：40/0 | 提交时间：2020/07/28
artemisinin artemisinin derivative cytosol receptor hemoglobin protein Kelch13 protozoal protein unclassified drug antimalarial agent cell drug resistance hemoglobin malaria mutation physiology protein antimalarial drug resistance Article controlled study endocytosis gene inactivation gene mutation host cell Kelch13 gene nonhuman Plasmodium priority journal protein analysis protein function |
| ZGLP1 is a determinant for the oogenic fate in mice 期刊论文
, 2020, 卷号: 367, 期号: 6482
作者: Nagaoka S.I.; Nakaki F.; Miyauchi H.; Nosaka Y.; Ohta H.; Yabuta Y.; Kurimoto K.; Hayashi K.; Nakamura T.; Yamamoto T.; Saitou M.
收藏 | 浏览/下载：53/0 | 提交时间：2020/07/28
bone morphogenetic protein bone cell gametogenesis germ cell maturation rodent signaling adult animal cell animal experiment animal model Article cell fate controlled study embryo female gain of function mutation gene gene overexpression genetic transcription in vitro study in vivo study loss of function mutation male meiotic prophase I mouse mouse embryonic stem cell nonhuman oocyte development priority journal retroposon RNA processing RNA sequencing signal transduction spermatogenesis Stra8 gene ZGLP1 gene Mammalia Mus |
| Genetics of schizophrenia in the South African Xhosa 期刊论文
, 2020, 卷号: 367, 期号: 6477
作者: Gulsuner S.; Stein D.J.; Susser E.S.; Sibeko G.; Pretorius A.; Walsh T.; Majara L.; Mndini M.M.; Mqulwana S.G.; Ntola O.A.; Casadei S.; Ngqengelele L.L.; Korchina V.; Van Der Merwe C.; Malan M.; Fader K.M.; Feng M.; Willoughby E.; Muzny D.; Baldinger A.; Andrews H.F.; Gur R.C.; Gibbs R.A.; Zingela Z.; Nagdee M.; Ramesar R.S.; King M.-C.; McClellan J.M.
收藏 | 浏览/下载：40/0 | 提交时间：2020/07/28
4 aminobutyric acid dopamine glutamine genetic analysis genetic variation genome genomics mutagenicity mutation Article connectome controlled study gene mutation genetic variability genetics human major clinical study nerve cell plasticity priority journal schizophrenia South African Xhosa (people) South Africa |
