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Computing cancer's weak spots 期刊论文
, 2020, 卷号: 368, 期号: 6496
作者:  Khamsi R.
收藏  |  浏览/下载：47/0  |  提交时间：2020/07/28
ruxolitinib  STAT3 protein  antineoplastic agent  transcription factor  algorithm  cancer  computer simulation  disease treatment  drug development  medicine  Article  cancer cell  cancer radiotherapy  enzyme inhibition  gene activity  gene expression regulation  gene interaction  gene mutation  gene repression  gene targeting  human  laboratory test  malignant neoplasm  molecular dynamics  nonhuman  oncologist  priority journal  RNA sequencing  algorithm  genetics  mutation  neoplasm  personalized medicine  procedures  systems biology  Algorithms  Antineoplastic Agents  Humans  Mutation  Neoplasms  Precision Medicine  Systems Biology  Transcription Factors  
Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者:  Walton R.T.;  Christie K.A.;  Whittaker M.N.;  Kleinstiver B.P.
收藏  |  浏览/下载：27/0  |  提交时间：2020/07/28
adenine  adenosine  CRISPR associated endonuclease Cas9  cytosine  guanosine  SpG protein  SpRY nuclease  thymine  unclassified drug  Cas9 endonuclease Streptococcus pyogenes  bacterium  enzyme activity  genetic engineering  genetic variation  genome  Article  CRISPR-CAS9 system  DNA sequence  enzyme activity  gene editing  gene targeting  genetic variability  human  mutagenesis  nonhuman  priority journal  protein engineering  protein motif  protein structure  protospacer adjacent motif  Streptococcus pyogenes  chemistry  CRISPR Cas system  enzyme specificity  gene editing  gene targeting  genetic predisposition  genetics  HEK293 cell line  procedures  protein domain  Streptococcus pyogenes  CRISPR-Associated Protein 9  CRISPR-Cas Systems  Gene Editing  Gene Targeting  Genetic Predisposition to Disease  HEK293 Cells  Humans  Mutagenesis  Protein Domains  Substrate Specificity  
Therapeutic targeting of preleukemia cells in a mouse model of NPM1 mutant acute myeloid leukemia 期刊论文
, 2020, 卷号: 367, 期号: 6477
作者:  Uckelmann H.J.;  Kim S.M.;  Wong E.M.;  Hatton C.;  Giovinazzo H.;  Gadrey J.Y.;  Krivtsov A.V.;  Rücker F.G.;  Döhner K.;  McGeehan G.M.;  Levine R.L.;  Bullinger L.;  Vassiliou G.S.;  Armstrong S.A.
收藏  |  浏览/下载：36/0  |  提交时间：2020/07/28
antileukemic agent  methionine  unclassified drug  vtp 50469  biological development  cancer  cell  disease treatment  mutation  numerical model  oral health  acute myeloid leukemia  animal cell  animal experiment  animal model  antineoplastic activity  Article  cell proliferation  cell self-renewal  chromatin  controlled study  drug targeting  gene  gene mutation  leukemia cell  molecularly targeted therapy  mouse  mouse model  nonhuman  NPM1 gene  preleukemia  priority journal  Mus  
The body's dangerous defenders 期刊论文
, 2020, 卷号: 367, 期号: 6482
作者:  Leslie M.
收藏  |  浏览/下载：39/0  |  提交时间：2020/07/28
alvelestat  avacopan  chemokine receptor CXCR2  danirixin  leukocyte elastase  n [2 (2,3 difluorobenzylthio) 6 (2,3 dihydroxy 1 methylpropoxy) 4 pyrimidinyl] 1 azetidinesulfonamide  nemiralisib  simvastatin  leukocyte elastase inhibitor  antimicrobial activity  apoptosis  cell  enzyme activity  physiological response  ANCA associated vasculitis  Article  autoimmune disease  autoimmunity  bacterial pneumonia  bactericidal activity  bronchiolitis obliterans  drug targeting  extracellular matrix  extracellular trap  hematopoietic stem cell transplantation  human  immunity  immunocompetent cell  infection  inflammation  lung disease  neutrophil  neutrophil chemotaxis  nonhuman  priority journal  risk factor  sepsis  single cell RNA seq  autoimmune disease  chronic obstructive lung disease  clinical trial (topic)  drug effect  enzymology  immunology  lung tumor  neutrophil  Autoimmune Diseases  Clinical Trials as Topic  Humans  Lung Neoplasms  Neutrophils  Proteinase Inhibitory Proteins, Secretory  Pulmonary Disease, Chronic Obstructive  
Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation 期刊论文
, 2020, 卷号: 368, 期号: 6489
作者:  Gilan O.;  Rioja I.;  Knezevic K.;  Bell M.J.;  Yeung M.M.;  Harker N.R.;  Lam E.Y.N.;  Chung C.;  Bamborough P.;  Petretich M.;  Urh M.;  Atkinson S.J.;  Bassil A.K.;  Roberts E.J.;  Vassiliadis D.;  Burr M.L.;  Preston A.G.S.;  Wellaway C.;  Werner T.;  Gray J.R.;  Michon A.-M.;  Gobbetti T.;  Kumar V.;  Soden P.E.;  Haynes A.;  Vappiani J.;  Tough D.F.;  Taylor S.;  Dawson S.-J.;  Bantscheff M.;  Lindon M.;  Drewes G.;  Demont E.H.;  Daniels D.L.;  Grandi P.;  Prinjha R.K.;  Dawson M.A.
收藏  |  浏览/下载：44/0  |  提交时间：2020/07/28
7 (3,5 dimethyl 4 isoxazolyl) 1,3 dihydro 8 methoxy 1 [1 (2 pyridinyl)ethyl] 2h imidazo[4,5 c]quinolin 2 one  apremilast  bromodomain and extraterminal domain protein 1  bromodomain and extraterminal domain protein 2  bromodomain inhibitor  gsk 046  gsk 620  gsk 778  transcription factor  unclassified drug  cancer  drug  gene expression  immune response  inhibitor  physiological response  acute myeloid leukemia  animal experiment  animal model  animal tissue  antibody response  antineoplastic activity  antiproliferative activity  apoptosis  Article  binding affinity  controlled study  crystal structure  drug design  drug efficacy  drug protein binding  drug selectivity  drug specificity  drug structure  drug targeting  gene expression  high throughput screening  human  human cell  IC50  immunomodulation  in vivo study  inflammation  K-562 cell line  malignant neoplasm  MDA-MB-453 cell line  MOLM-13 cell line  mouse  nonhuman  priority journal  psoriasis  
Structure of CD20 in complex with the therapeutic monoclonal antibody rituximab 期刊论文
, 2020, 卷号: 367, 期号: 6483
作者:  Rougé L.;  Chiang N.;  Steffek M.;  Kugel C.;  Croll T.I.;  Tam C.;  Estevez A.;  Arthur C.P.;  Koth C.M.;  Ciferri C.;  Kraft E.;  Payandeh J.;  Nakamura G.;  Koerber J.T.;  Rohou A.
收藏  |  浏览/下载：26/0  |  提交时间：2020/07/28
CD20 antigen  dimer  epitope  Fc receptor  immunoglobulin F(ab) fragment  obinutuzumab  ocrelizumab  ofatumumab  rituximab  tositumomab i 131  antibody  antigen  cell  chemical binding  composite  gene expression  genetic marker  protein  amino acid sequence  antibody dependent cellular cytotoxicity  antigen antibody complex  antigen binding  antigen structure  Article  cell death  cell surface  chemical bond  complement dependent cytotoxicity  drug protein binding  drug targeting  electron microscopy  human  humoral immune deficiency  insect cell  lipid raft  malignant neoplasm  molecular recognition  multiple sclerosis  nonhuman  phagocytosis  priority journal  protein cross linking  protein interaction  stoichiometry  surface plasmon resonance