|
已选(0)清除
条数/页： 排序方式： |
| Computing cancer's weak spots 期刊论文
, 2020, 卷号: 368, 期号: 6496
作者: Khamsi R.
  收藏 | 浏览/下载：47/0 | 提交时间：2020/07/28
ruxolitinib STAT3 protein antineoplastic agent transcription factor algorithm cancer computer simulation disease treatment drug development medicine Article cancer cell cancer radiotherapy enzyme inhibition gene activity gene expression regulation gene interaction gene mutation gene repression gene targeting human laboratory test malignant neoplasm molecular dynamics nonhuman oncologist priority journal RNA sequencing algorithm genetics mutation neoplasm personalized medicine procedures systems biology Algorithms Antineoplastic Agents Humans Mutation Neoplasms Precision Medicine Systems Biology Transcription Factors |
| Transcription factor AP2 controls cnidarian germ cell induction 期刊论文
, 2020, 卷号: 367, 期号: 6479
作者: DuBuc T.Q.; Schnitzler C.E.; Chrysostomou E.; McMahon E.T.; Febrimarsa; Gahan J.M.; Buggie T.; Gornik S.G.; Hanley S.; Barreira S.N.; Gonzalez P.; Baxevanis A.D.; Frank U.
收藏 | 浏览/下载：37/0 | 提交时间：2020/07/28
transcription factor transcription factor AP2 unclassified drug clonal organism gene expression germ cell invertebrate physiological response protein adult Article cell fate Cnidaria embryo female genotype germ cell gonad development Hydractinia symbiolongicarpus male nonhuman phenotype priority journal protein expression wild type Animalia Bilateria Hydractinia symbiolongicarpus Mammalia |
| Therapeutic targeting of preleukemia cells in a mouse model of NPM1 mutant acute myeloid leukemia 期刊论文
, 2020, 卷号: 367, 期号: 6477
作者: Uckelmann H.J.; Kim S.M.; Wong E.M.; Hatton C.; Giovinazzo H.; Gadrey J.Y.; Krivtsov A.V.; Rücker F.G.; Döhner K.; McGeehan G.M.; Levine R.L.; Bullinger L.; Vassiliou G.S.; Armstrong S.A.
收藏 | 浏览/下载：36/0 | 提交时间：2020/07/28
antileukemic agent methionine unclassified drug vtp 50469 biological development cancer cell disease treatment mutation numerical model oral health acute myeloid leukemia animal cell animal experiment animal model antineoplastic activity Article cell proliferation cell self-renewal chromatin controlled study drug targeting gene gene mutation leukemia cell molecularly targeted therapy mouse mouse model nonhuman NPM1 gene preleukemia priority journal Mus |
| Meet the psychobiome 期刊论文
, 2020, 卷号: 368, 期号: 6491
作者: Pennisi E.
收藏 | 浏览/下载：35/0 | 提交时间：2020/07/28
4 aminobutyric acid antibiotic agent dopamine kynurenine probiotic agent queuine serotonin psychotropic agent bacterium biome drug microbial activity nervous system disorder allergy Alzheimer disease antimicrobial therapy anxiety disorder archaeon Article autism bacterium culture Bacteroides blood brain barrier blood vessel brain disease clinical effectiveness constipation depression drug use enteroendocrine cell enteropathy entrepreneurship epilepsy fecal microbiota transplantation feces analysis Food and Drug Administration fungus genomics human insomnia intestine flora irritable colon mammal cell microbiology microbiome nerve cell nervous system nervous system development neurologic disease nonhuman obesity pain threshold Parkinson disease physician priority journal psychobiome psychological aspect psychological well-being schizophrenia scientist United States vagus nerve virus animal bacterium chemistry drug development intestine flora isolation and purification metabolism microbiology physiology procedures Animals Bacteria Drug Discovery Gastrointestinal Microbiome Humans Nervous System Diseases Psychotropic Drugs |
| Maternal gut microbiota in pregnancy influences offspring metabolic phenotype in mice 期刊论文
, 2020, 卷号: 367, 期号: 6481
作者: Kimura I.; Miyamoto J.; Ohue-Kitano R.; Watanabe K.; Yamada T.; Onuki M.; Aoki R.; Isobe Y.; Kashihara D.; Inoue D.; Inaba A.; Takamura Y.; Taira S.; Kumaki S.; Watanabe M.; Ito M.; Nakagawa F.; Irie J.; Kakuta H.; Shinohara M.; Iwatsuki K.; Tsujimoto G.; Ohno H.; Arita M.; Itoh H.; Hase K.
收藏 | 浏览/下载：46/0 | 提交时间：2020/07/28
G protein coupled receptor G protein coupled receptor 41 G protein coupled receptor 43 glucagon like peptide 1 short chain fatty acid unclassified drug disease incidence experimental study female microbial community phenotype pregnancy rodent adult animal cell animal experiment animal model animal tissue Article C57BL 6 mouse cell differentiation controlled study developmental stage diet composition diet supplementation dietary exposure disease exacerbation disease predisposition embryo embryo development energy metabolism enteroendocrine cell female fiber intake germfree animal glucose intolerance high risk pregnancy hyperglycemia Institute for Cancer Research mouse insulin metabolism intestine flora lipid diet low fiber diet male maternal nutrition metabolic syndrome X mouse newborn nonhuman obesity pancreas islet beta cell phenotype pregnancy prenatal development priority journal progeny protein expression risk reduction Mus |
| Translating preclinical models to humans 期刊论文
, 2020, 卷号: 367, 期号: 6479
作者: Brubaker D.K.; Lauffenburger D.A.
收藏 | 浏览/下载：41/0 | 提交时间：2020/07/28
detection method model Article bioengineering biomedicine cell differentiation cell proliferation computer model conceptual framework DNA sequence drug development epithelium cell gene expression profiling high throughput sequencing human machine learning molecular dynamics nonhuman phenotype priority journal proteomics RNA sequence sex difference signal transduction T lymphocyte transcription regulation transcriptomics translational research |
| VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance 期刊论文
, 2020, 卷号: 367, 期号: 6475
作者: ElTanbouly M.A.; Zhao Y.; Nowak E.; Li J.; Schaafsma E.; Le Mercier I.; Ceeraz S.; Lines J.L.; Peng C.; Carriere C.; Huang X.; Day M.; Koehn B.; Lee S.W.; Morales M.S.; Hogquist K.A.; Jameson S.C.; Mueller D.; Rothstein J.; Blazar B.R.; Cheng C.; Noelle R.J.
收藏 | 浏览/下载：57/0 | 提交时间：2020/07/28
cell protein interferon kruppel like factor 2 T lymphocyte receptor unclassified drug V type immunoglobulin domain containing suppressor of T cell activation protein B7 antigen Dies1 protein, mouse lymphocyte antigen receptor membrane protein monoclonal antibody VSIR protein, human biological development cell gene expression heterogeneity homeostasis immune response immunity tolerance acute graft versus host disease animal cell animal experiment animal model Article CD4+ T lymphocyte cell death cell expansion cell fate cell heterogeneity cell loss cell survival controlled study female gene gene deletion homeostasis immunological tolerance in vivo study long term survival male mouse nonhuman phenotype priority journal protein expression protein function rheumatoid arthritis RNA sequencing systemic lupus erythematosus T lymphocyte T lymphocyte activation T lymphocyte subpopulation TCR gene upregulation VISTA gene animal C57BL mouse genetics immunological tolerance immunology knockout mouse lymphocyte activation physiology T lymphocyte Mus Animals Antibodies, Monoclonal B7 Antigens Lymphocyte Activation Membrane Proteins Mice Mice, Inbred C57BL Mice, Knockout Peripheral Tolerance Receptors, Antigen, T-Cell T-Lymphocytes |
| Peptide signaling for drought-induced tomato flower drop 期刊论文
, 2020, 卷号: 367, 期号: 6485
作者: Reichardt S.; Piepho H.-P.; Stintzi A.; Schaller A.
收藏 | 浏览/下载：42/0 | 提交时间：2020/07/28
mitogen activated protein kinase peptide hormone phytaspase 2 phytosulfokine unclassified drug abscission aspartic acid crop yield drought stress enzyme activity flower fruit gene expression hormone peptide abscission Arabidopsis Article bioassay cell separation controlled study cytokine production down regulation drought environmental stress enzyme activity enzyme specificity ERF4 gene ERT10 gene flower hydrolysis hydrophobicity IAA3 gene immunomodulation molecular dynamics nonhuman peptide signaling PK7 gene plant development plant genome priority journal productivity protein cleavage protein degradation protein expression protein function protein processing regulator gene signal transduction tomato TPRP gene Lycopersicon esculentum |
| Vertebrate diapause preserves organisms long term through Polycomb complex members 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者: Hu C.-K.; Wang W.; Brind'Amour J.; Singh P.P.; Adam Reeves G.; Lorincz M.C.; Alvarado A.S.; Brunet A.
收藏 | 浏览/下载：44/0 | 提交时间：2020/07/28
polycomb group protein protein CBX7 transcriptome unclassified drug diapause gene expression metabolism muscle vertebrate Article chromatin complex formation developmental gene diapause down regulation embryo development fertility gene gene expression regulation gene repression genetic regulation growth rate lifespan lipid metabolism metabolism muscle atrophy muscle gene neuromuscular junction nonhuman priority journal protein function tissue preservation upregulation vertebrate Cyprinodontoidei Nothobranchius furzeri Vertebrata |
| A two-way molecular dialogue between embryo and endosperm is required for seed development 期刊论文
, 2020, 卷号: 367, 期号: 6476
作者: Doll N.M.; Royek S.; Fujita S.; Okuda S.; Chamot S.; Stintzi A.; Widiez T.; Hothorn M.; Schaller A.; Geldner N.; Ingram G.
收藏 | 浏览/下载：46/0 | 提交时间：2020/07/28
GASSHO receptor plant protein twisted seed1 unclassified drug cuticle embryo enzyme activity gene expression germination molecular analysis peptide signaling Article controlled study endosperm germination mutant nonhuman plant embryo plant seed priority journal protein cleavage protein function seed development signal transduction sulfation |
