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| Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease 期刊论文
, 2020, 卷号: 368, 期号: 6497
作者: Dai W.; Zhang B.; Jiang X.-M.; Su H.; Li J.; Zhao Y.; Xie X.; Jin Z.; Peng J.; Liu F.; Li C.; Li Y.; Bai F.; Wang H.; Cheng X.; Cen X.; Hu S.; Yang X.; Wang J.; Liu X.; Xiao G.; Jiang H.; Rao Z.; Zhang L.-K.; Xu Y.; Yang H.; Liu H.
  收藏 | 浏览/下载：47/0 | 提交时间：2020/07/28
aldehyde antimicrobial activity drug enzyme activity infectivity inhibitor reaction kinetics viral disease Coronavirus SARS coronavirus 3C-like proteinase, Coronavirus antivirus agent cysteine proteinase viral protein animal Betacoronavirus chemical structure chemistry Chlorocebus aethiops Coronavirus infection dog drug design drug effect enzyme active site enzymology female human male mouse pandemic preclinical study protein tertiary structure Sprague Dawley rat toxicity testing Vero cell line virus pneumonia Animals Antiviral Agents Betacoronavirus Catalytic Domain Chlorocebus aethiops Coronavirus Infections Cysteine Endopeptidases Dogs Drug Design Drug Evaluation, Preclinical Female Humans Male Mice Molecular Structure Pandemics Pneumonia, Viral Protein Structure, Tertiary Rats, Sprague-Dawley Toxicity Tests Vero Cells Viral Nonstructural Proteins |
| T cells with dysfunctional mitochondria induce multimorbidity and premature senescence 期刊论文
, 2020, 卷号: 368, 期号: 6497
作者: Desdín-Micó G.; Soto-Heredero G.; Aranda J.F.; Oller J.; Carrasco E.; Gabandé-Rodríguez E.; Blanco E.M.; Alfranca A.; Cussó L.; Desco M.; Ibañez B.; Gortazar A.R.; Fernández-Marcos P.; Navarro M.N.; Hernaez B.; Alcamí A.; Baixauli F.; Mittelbrunn M.
收藏 | 浏览/下载：47/0 | 提交时间：2020/07/28
cardiovascular disease enzyme activity gene expression metabolism mitochondrial DNA morbidity senescence tumor Mus DNA binding protein mitochondrial protein mitochondrial transcription factor A nicotinamide adenine dinucleotide transcription factor tumor necrosis factor animal cytokine release syndrome female fitness gene deletion genetics immunology inflammation longevity male metabolism mitochondrion mouse multiple chronic conditions mutant mouse strain premature aging T lymphocyte ultrastructure Aging, Premature Animals Cytokine Release Syndrome DNA-Binding Proteins Female Gene Deletion Inflammation Longevity Male Mice Mice, Mutant Strains Mitochondria Mitochondrial Proteins Multimorbidity NAD Physical Fitness T-Lymphocytes Transcription Factors Tumor Necrosis Factor-alpha |
| Computing cancer's weak spots 期刊论文
, 2020, 卷号: 368, 期号: 6496
作者: Khamsi R.
收藏 | 浏览/下载：48/0 | 提交时间：2020/07/28
ruxolitinib STAT3 protein antineoplastic agent transcription factor algorithm cancer computer simulation disease treatment drug development medicine Article cancer cell cancer radiotherapy enzyme inhibition gene activity gene expression regulation gene interaction gene mutation gene repression gene targeting human laboratory test malignant neoplasm molecular dynamics nonhuman oncologist priority journal RNA sequencing algorithm genetics mutation neoplasm personalized medicine procedures systems biology Algorithms Antineoplastic Agents Humans Mutation Neoplasms Precision Medicine Systems Biology Transcription Factors |
| Elesclomol alleviates Menkes pathology and mortality by escorting Cu to cuproenzymes in mice 期刊论文
, 2020, 卷号: 368, 期号: 6491
作者: Guthrie L.M.; Soma S.; Yuan S.; Silva A.; Zulkifli M.; Snavely T.C.; Greene H.F.; Nunez E.; Lynch B.; de Ville C.; Shanbhag V.; Lopez F.R.; Acharya A.; Petris M.J.; Kim B.-E.; Gohil V.M.; Sacchettini J.C.
收藏 | 浏览/下载：39/0 | 提交时间：2020/07/28
copper copper zinc superoxide dismutase cytochrome c oxidase dopamine beta monooxygenase elesclomol monophenol monooxygenase protein lysine 6 oxidase copper cytochrome c oxidase elesclomol hydrazine derivative copper cytochrome enzyme enzyme activity mitochondrion mortality mutation pathology rodent survival animal cell animal experiment animal model animal tissue Article cohort analysis controlled study disease severity drug mechanism Golgi complex H9c2(2-1) cell line in vivo study male Menkes syndrome mitochondrial dynamics mortality rate mouse nerve degeneration nonhuman priority journal secretory pathway survival rate animal brain cell line degenerative disease disease model drug effect genetics knockout mouse Menkes syndrome metabolism mitochondrion pathology rat transport at the cellular level Murinae Mus Animals Biological Transport Brain Cell Line Copper Copper Transporter 1 Disease Models, Animal Electron Transport Complex IV Hydrazines Male Menkes Kinky Hair Syndrome Mice Mice, Knockout Mitochondria Neurodegenerative Diseases Rats |
| Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者: Walton R.T.; Christie K.A.; Whittaker M.N.; Kleinstiver B.P.
收藏 | 浏览/下载：27/0 | 提交时间：2020/07/28
adenine adenosine CRISPR associated endonuclease Cas9 cytosine guanosine SpG protein SpRY nuclease thymine unclassified drug Cas9 endonuclease Streptococcus pyogenes bacterium enzyme activity genetic engineering genetic variation genome Article CRISPR-CAS9 system DNA sequence enzyme activity gene editing gene targeting genetic variability human mutagenesis nonhuman priority journal protein engineering protein motif protein structure protospacer adjacent motif Streptococcus pyogenes chemistry CRISPR Cas system enzyme specificity gene editing gene targeting genetic predisposition genetics HEK293 cell line procedures protein domain Streptococcus pyogenes CRISPR-Associated Protein 9 CRISPR-Cas Systems Gene Editing Gene Targeting Genetic Predisposition to Disease HEK293 Cells Humans Mutagenesis Protein Domains Substrate Specificity |
| Therapeutic targeting of preleukemia cells in a mouse model of NPM1 mutant acute myeloid leukemia 期刊论文
, 2020, 卷号: 367, 期号: 6477
作者: Uckelmann H.J.; Kim S.M.; Wong E.M.; Hatton C.; Giovinazzo H.; Gadrey J.Y.; Krivtsov A.V.; Rücker F.G.; Döhner K.; McGeehan G.M.; Levine R.L.; Bullinger L.; Vassiliou G.S.; Armstrong S.A.
收藏 | 浏览/下载：37/0 | 提交时间：2020/07/28
antileukemic agent methionine unclassified drug vtp 50469 biological development cancer cell disease treatment mutation numerical model oral health acute myeloid leukemia animal cell animal experiment animal model antineoplastic activity Article cell proliferation cell self-renewal chromatin controlled study drug targeting gene gene mutation leukemia cell molecularly targeted therapy mouse mouse model nonhuman NPM1 gene preleukemia priority journal Mus |
| Meet the psychobiome 期刊论文
, 2020, 卷号: 368, 期号: 6491
作者: Pennisi E.
收藏 | 浏览/下载：38/0 | 提交时间：2020/07/28
4 aminobutyric acid antibiotic agent dopamine kynurenine probiotic agent queuine serotonin psychotropic agent bacterium biome drug microbial activity nervous system disorder allergy Alzheimer disease antimicrobial therapy anxiety disorder archaeon Article autism bacterium culture Bacteroides blood brain barrier blood vessel brain disease clinical effectiveness constipation depression drug use enteroendocrine cell enteropathy entrepreneurship epilepsy fecal microbiota transplantation feces analysis Food and Drug Administration fungus genomics human insomnia intestine flora irritable colon mammal cell microbiology microbiome nerve cell nervous system nervous system development neurologic disease nonhuman obesity pain threshold Parkinson disease physician priority journal psychobiome psychological aspect psychological well-being schizophrenia scientist United States vagus nerve virus animal bacterium chemistry drug development intestine flora isolation and purification metabolism microbiology physiology procedures Animals Bacteria Drug Discovery Gastrointestinal Microbiome Humans Nervous System Diseases Psychotropic Drugs |
| The body's dangerous defenders 期刊论文
, 2020, 卷号: 367, 期号: 6482
作者: Leslie M.
收藏 | 浏览/下载：39/0 | 提交时间：2020/07/28
alvelestat avacopan chemokine receptor CXCR2 danirixin leukocyte elastase n [2 (2,3 difluorobenzylthio) 6 (2,3 dihydroxy 1 methylpropoxy) 4 pyrimidinyl] 1 azetidinesulfonamide nemiralisib simvastatin leukocyte elastase inhibitor antimicrobial activity apoptosis cell enzyme activity physiological response ANCA associated vasculitis Article autoimmune disease autoimmunity bacterial pneumonia bactericidal activity bronchiolitis obliterans drug targeting extracellular matrix extracellular trap hematopoietic stem cell transplantation human immunity immunocompetent cell infection inflammation lung disease neutrophil neutrophil chemotaxis nonhuman priority journal risk factor sepsis single cell RNA seq autoimmune disease chronic obstructive lung disease clinical trial (topic) drug effect enzymology immunology lung tumor neutrophil Autoimmune Diseases Clinical Trials as Topic Humans Lung Neoplasms Neutrophils Proteinase Inhibitory Proteins, Secretory Pulmonary Disease, Chronic Obstructive |
| Structure of nucleosome-bound human BAF complex 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者: He S.; Wu Z.; Tian Y.; Yu Z.; Yu J.; Wang X.; Li J.; Liu B.; Xu Y.
收藏 | 浏览/下载：38/0 | 提交时间：2020/07/28
actin related protein adenosine triphosphatase BRG1 BRM associated factor DNA multiprotein complex protein SWI retinoblastoma binding protein 2 SMARCC protein SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily B member 1 transcription factor transcription factor SNF unclassified drug cancer enzyme activity gene expression hydrolysis mutation protein alpha helix Article carboxy terminal sequence cell interaction cryoelectron microscopy disease association human malignant neoplasm molecular recognition mutation nucleosome priority journal protein function protein hydrolysis protein structure structure analysis Mammalia |
| Size matters but is big always better? Effectiveness of urea and Phlebiopsis gigantea as treatment against Heterobasidion on Picea abies stumps of variable size 期刊论文
, 2020, 卷号: 462
作者: Blomquist M.; Larsson Herrera S.; Hofmann J.; Beram R.C.; Cleary M.; Rönnberg J.
收藏 | 浏览/下载：39/0 | 提交时间：2020/07/28
Metabolism Plants (botany) Urea Airborne infection Biological control agent Coniferous forests Northern Hemispheres Norway spruce stands Phlebiopsis gigantea Pre-commercial thinning Standard practices Forestry airborne survey biological control coniferous forest economic activity forest management fungal disease Northern Hemisphere stand structure thinning urea Diseases Felling Forestry Frequency Metabolism Processing Stumps Urea Sweden Heterobasidion Phlebiopsis gigantea Picea abies |
