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Elesclomol alleviates Menkes pathology and mortality by escorting Cu to cuproenzymes in mice
期刊论文
, 2020, 卷号: 368, 期号: 6491
作者:
Guthrie L.M.
;
Soma S.
;
Yuan S.
;
Silva A.
;
Zulkifli M.
;
Snavely T.C.
;
Greene H.F.
;
Nunez E.
;
Lynch B.
;
de Ville C.
;
Shanbhag V.
;
Lopez F.R.
;
Acharya A.
;
Petris M.J.
;
Kim B.-E.
;
Gohil V.M.
;
Sacchettini J.C.
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2020/07/28
copper
copper zinc superoxide dismutase
cytochrome c oxidase
dopamine beta monooxygenase
elesclomol
monophenol monooxygenase
protein lysine 6 oxidase
copper
cytochrome c oxidase
elesclomol
hydrazine derivative
copper
cytochrome
enzyme
enzyme activity
mitochondrion
mortality
mutation
pathology
rodent
survival
animal cell
animal experiment
animal model
animal tissue
Article
cohort analysis
controlled study
disease severity
drug mechanism
Golgi complex
H9c2(2-1) cell line
in vivo study
male
Menkes syndrome
mitochondrial dynamics
mortality rate
mouse
nerve degeneration
nonhuman
priority journal
secretory pathway
survival rate
animal
brain
cell line
degenerative disease
disease model
drug effect
genetics
knockout mouse
Menkes syndrome
metabolism
mitochondrion
pathology
rat
transport at the cellular level
Murinae
Mus
Animals
Biological Transport
Brain
Cell Line
Copper
Copper Transporter 1
Disease Models, Animal
Electron Transport Complex IV
Hydrazines
Male
Menkes Kinky Hair Syndrome
Mice
Mice, Knockout
Mitochondria
Neurodegenerative Diseases
Rats
Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model
期刊论文
, 2020, 卷号: 368, 期号: 6494
作者:
Rockx B.
;
Kuiken T.
;
Herfst S.
;
Bestebroer T.
;
Lamers M.M.
;
Munnink B.B.O.
;
De Meulder D.
;
Van Amerongen G.
;
Van Den Brand J.
;
Okba N.M.A.
;
Schipper D.
;
Van Run P.
;
Leijten L.
;
Sikkema R.
;
Verschoor E.
;
Verstrepen B.
;
Bogers W.
;
Langermans J.
;
Langermans J.
;
Drosten C.
;
Van Vlissingen M.F.
;
Fouchier R.
;
De Swart R.
;
Koopmans M.
;
Haagmans B.L.
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2020/07/28
pathogenicity
pathology
primate
severe acute respiratory syndrome
viral disease
virus
Middle East
Coronavirus
Macaca
Primates
SARS coronavirus
aging
animal
Betacoronavirus
comparative study
Coronavirus infection
disease model
female
isolation and purification
lung
lung alveolus
Macaca fascicularis
Middle East respiratory syndrome coronavirus
pandemic
pathogenicity
pathology
physiology
respiratory system
SARS coronavirus
severe acute respiratory syndrome
virology
virus pneumonia
virus replication
virus shedding
Aging
Animals
Betacoronavirus
Coronavirus Infections
Disease Models, Animal
Female
Lung
Macaca fascicularis
Middle East Respiratory Syndrome Coronavirus
Pandemics
Pneumonia, Viral
Pulmonary Alveoli
Respiratory System
SARS Virus
Severe Acute Respiratory Syndrome
Virus Replication
Virus Shedding
Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS-coronavirus 2
期刊论文
, 2020, 卷号: 368, 期号: 6494
作者:
Shi J.
;
Wen Z.
;
Zhong G.
;
Yang H.
;
Wang C.
;
Huang B.
;
Liu R.
;
He X.
;
Shuai L.
;
Sun Z.
;
Zhao Y.
;
Liu P.
;
Liang L.
;
Cui P.
;
Wang J.
;
Zhang X.
;
Guan Y.
;
Tan W.
;
Wu G.
;
Chen H.
;
Bu Z.
;
Bu Z.
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2020/07/28
bat
canid
disease control
disease transmission
felid
global perspective
infectious disease
poultry
severe acute respiratory syndrome
viral disease
virus
China
Hubei
Wuhan
Anas
Animalia
Canis familiaris
Coronavirus
Gallus gallus
Mustela
SARS coronavirus
Suidae
virus antibody
virus RNA
animal
Betacoronavirus
blood
cat
chicken
Coronavirus infection
disease model
disease predisposition
dog
domestic animal
duck
feces
female
immunology
isolation and purification
male
Mustela putorius furo
pandemic
physiology
pig
respiratory system
species difference
virology
virus attachment
virus pneumonia
virus replication
Animals
Animals, Domestic
Antibodies, Viral
Betacoronavirus
Cats
Chickens
Coronavirus Infections
Disease Models, Animal
Disease Susceptibility
Dogs
Ducks
Feces
Female
Ferrets
Male
Pandemics
Pneumonia, Viral
Respiratory System
RNA, Viral
Species Specificity
Sus scrofa
Virus Attachment
Virus Replication
A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2
期刊论文
, 2020, 卷号: 368, 期号: 6496
作者:
Wu Y.
;
Wang F.
;
Shen C.
;
Peng W.
;
Li D.
;
Zhao C.
;
Li Z.
;
Li S.
;
Bi Y.
;
Yang Y.
;
Gong Y.
;
Xiao H.
;
Fan Z.
;
Tan S.
;
Wu G.
;
Tan W.
;
Lu X.
;
Fan C.
;
Wang Q.
;
Liu Y.
;
Zhang C.
;
Qi J.
;
Gao G.F.
;
Gao F.
;
Liu L.
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2020/07/28
Coronavirus
angiotensin converting enzyme 2
coronavirus spike glycoprotein
dipeptidyl carboxypeptidase
epitope
monoclonal antibody
neutralizing antibody
virus antibody
virus receptor
animal
chemistry
Coronavirus infection
disease model
human
immunology
isolation and purification
lung
mouse
pandemic
protein domain
serodiagnosis
virology
virus load
virus pneumonia
Animals
Antibodies, Monoclonal
Antibodies, Neutralizing
Antibodies, Viral
Coronavirus Infections
Disease Models, Animal
Humans
Immunodominant Epitopes
Lung
Mice
Neutralization Tests
Pandemics
Peptidyl-Dipeptidase A
Pneumonia, Viral
Protein Domains
Receptors, Virus
Spike Glycoprotein, Coronavirus
Viral Load
Rewilding immunology
期刊论文
, 2020, 卷号: 369, 期号: 6499
作者:
Flies A.S.
;
Wild Comparative Immunology Consortium
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2020/07/28
animal
bat
communicable disease
Coronavirus infection
disease model
domestic animal
ecosystem
human
immune system
immunology
pandemic
veterinary medicine
virus pneumonia
wild animal
Allergy and Immunology
Animals
Animals, Domestic
Animals, Wild
Chiroptera
Communicable Diseases, Emerging
Coronavirus Infections
Disease Models, Animal
Ecosystem
Humans
Immune System
Pandemics
Pneumonia, Viral