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Differential response of human lung epithelial cells to particulate matter in fresh and photochemically aged biomass-burning smoke 期刊论文
ATMOSPHERIC ENVIRONMENT, 2022
作者:  Atwi K.;  Wilson S.N.;  Mondal A.;  Edenfield R.C.;  Symosko Crow K.M.;  El Hajj O.;  Perrie C.;  Glenn C.K.;  Easley C.A.;  IV;  Handa H.;  Saleh R.
收藏  |  浏览/下载：45/0  |  提交时间：2022/01/18
Apoptosis  Atmospheric aging  Mitochondrial dysfunction  Organic aerosol  Toxicity  Wildland fires  
N-salicyloyl tryptamine derivatives as potential therapeutic agents for Alzheimer's disease with neuroprotective effects 期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 115
作者:  Bai, Yinliang;  Liu, Dan;  Zhang, Honghua;  Wang, Yuying;  Wang, Degui;  Cai, Hongbin;  Wen, Huaixiu;  Yuan, Guoqiang;  An, Hui;  Wang, Yali;  Shi, Tao;  Wang, Zhen
收藏  |  浏览/下载：45/0  |  提交时间：2022/04/28
CELL-DEATH  INFLAMMASOME  PYROPTOSIS  NEUROINFLAMMATION  MICROGLIA  MECHANISM  APOPTOSIS  
CFLIPL protects macrophages from LPS-induced pyroptosis via inhibition of complex II formation 期刊论文
, 2020, 卷号: 367, 期号: 6484
作者:  Muendlein H.I.;  Jetton D.;  Connolly W.M.;  Eidell K.P.;  Magri Z.;  Smirnova I.;  Poltorak A.
收藏  |  浏览/下载：49/0  |  提交时间：2020/07/28
FLICE inhibitory protein  interleukin 1beta  lipopolysaccharide  messenger RNA  succinate dehydrogenase (ubiquinone)  Casp1 protein, mouse  caspase 8  Cflar protein, mouse  cryopyrin  FLICE inhibitory protein  IL1B protein, mouse  inflammasome  interleukin 1beta  interleukin 1beta converting enzyme  lipopolysaccharide  succinate dehydrogenase (ubiquinone)  cell  enzyme activity  inhibition  maturation  protein  animal cell  animal experiment  Article  bone marrow derived macrophage  cell death  cell protection  complex formation  controlled study  cytokine release  in vitro study  inflammation  mouse  nonhuman  priority journal  protein analysis  protein degradation  protein function  protein interaction  pyroptosis  animal  gene knockdown  genetics  immunology  macrophage  macrophage activation  metabolism  physiology  Murinae  Animals  CASP8 and FADD-Like Apoptosis Regulating Protein  Caspase 1  Caspase 8  Electron Transport Complex II  Gene Knockdown Techniques  Inflammasomes  Interleukin-1beta  Lipopolysaccharides  Macrophage Activation  Macrophages  Mice  NLR Family, Pyrin Domain-Containing 3 Protein  Pyroptosis  
Pathological damage, immune-related protein expression, and oxidative stress in lungs of BALB/c mice induced by haze PM2.5 biological components exposure 期刊论文
ATMOSPHERIC ENVIRONMENT, 2020, 卷号: 223
作者:  Wu B.;  Dong Y.;  Wang M.;  Yang W.;  Hu L.;  Zhou D.;  Lv J.;  Chai T.
收藏  |  浏览/下载：44/0  |  提交时间：2022/01/18
Apoptosis  Haze  Immune related protein  Oxidative stress  Pathological pulmonary damage  PM2.5  
The body's dangerous defenders 期刊论文
, 2020, 卷号: 367, 期号: 6482
作者:  Leslie M.
收藏  |  浏览/下载：39/0  |  提交时间：2020/07/28
alvelestat  avacopan  chemokine receptor CXCR2  danirixin  leukocyte elastase  n [2 (2,3 difluorobenzylthio) 6 (2,3 dihydroxy 1 methylpropoxy) 4 pyrimidinyl] 1 azetidinesulfonamide  nemiralisib  simvastatin  leukocyte elastase inhibitor  antimicrobial activity  apoptosis  cell  enzyme activity  physiological response  ANCA associated vasculitis  Article  autoimmune disease  autoimmunity  bacterial pneumonia  bactericidal activity  bronchiolitis obliterans  drug targeting  extracellular matrix  extracellular trap  hematopoietic stem cell transplantation  human  immunity  immunocompetent cell  infection  inflammation  lung disease  neutrophil  neutrophil chemotaxis  nonhuman  priority journal  risk factor  sepsis  single cell RNA seq  autoimmune disease  chronic obstructive lung disease  clinical trial (topic)  drug effect  enzymology  immunology  lung tumor  neutrophil  Autoimmune Diseases  Clinical Trials as Topic  Humans  Lung Neoplasms  Neutrophils  Proteinase Inhibitory Proteins, Secretory  Pulmonary Disease, Chronic Obstructive  
A programmable fate decision landscape underlies single-cell aging in yeast 期刊论文
, 2020, 卷号: 369, 期号: 6501
作者:  Li Y.;  Jiang Y.;  Paxman J.;  O'Laughlin R.;  Klepin S.;  Zhu Y.;  Pillus L.;  Tsimring L.S.;  Hasty J.;  Hao N.
收藏  |  浏览/下载：43/0  |  提交时间：2020/07/28
apoptosis  article  cell aging  cell differentiation  chromatin  epigenetics  lifespan  noise  nonhuman  yeast  
Autoreactivity in naïve human fetal B cells is associated with commensal bacteria recognition 期刊论文
, 2020, 卷号: 369, 期号: 6501
作者:  Chen J.W.;  Rice T.A.;  Bannock J.M.;  Bielecka A.A.;  Strauss J.D.;  Catanzaro J.R.;  Wang H.;  Menard L.C.;  Anolik J.H.;  Palm N.W.;  Meffre E.
收藏  |  浏览/下载：35/0  |  提交时间：2020/07/28
adult  apoptosis  article  B lymphocyte  cell specificity  commensal  efferocytosis  fetus  fetus liver  human  human cell  human tissue  intestine flora  nonhuman  spleen  
Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation 期刊论文
, 2020, 卷号: 368, 期号: 6489
作者:  Gilan O.;  Rioja I.;  Knezevic K.;  Bell M.J.;  Yeung M.M.;  Harker N.R.;  Lam E.Y.N.;  Chung C.;  Bamborough P.;  Petretich M.;  Urh M.;  Atkinson S.J.;  Bassil A.K.;  Roberts E.J.;  Vassiliadis D.;  Burr M.L.;  Preston A.G.S.;  Wellaway C.;  Werner T.;  Gray J.R.;  Michon A.-M.;  Gobbetti T.;  Kumar V.;  Soden P.E.;  Haynes A.;  Vappiani J.;  Tough D.F.;  Taylor S.;  Dawson S.-J.;  Bantscheff M.;  Lindon M.;  Drewes G.;  Demont E.H.;  Daniels D.L.;  Grandi P.;  Prinjha R.K.;  Dawson M.A.
收藏  |  浏览/下载：44/0  |  提交时间：2020/07/28
7 (3,5 dimethyl 4 isoxazolyl) 1,3 dihydro 8 methoxy 1 [1 (2 pyridinyl)ethyl] 2h imidazo[4,5 c]quinolin 2 one  apremilast  bromodomain and extraterminal domain protein 1  bromodomain and extraterminal domain protein 2  bromodomain inhibitor  gsk 046  gsk 620  gsk 778  transcription factor  unclassified drug  cancer  drug  gene expression  immune response  inhibitor  physiological response  acute myeloid leukemia  animal experiment  animal model  animal tissue  antibody response  antineoplastic activity  antiproliferative activity  apoptosis  Article  binding affinity  controlled study  crystal structure  drug design  drug efficacy  drug protein binding  drug selectivity  drug specificity  drug structure  drug targeting  gene expression  high throughput screening  human  human cell  IC50  immunomodulation  in vivo study  inflammation  K-562 cell line  malignant neoplasm  MDA-MB-453 cell line  MOLM-13 cell line  mouse  nonhuman  priority journal  psoriasis  
An AMPK–caspase-6 axis controls liver damage in nonalcoholic steatohepatitis 期刊论文
, 2020, 卷号: 367, 期号: 6478
作者:  Zhao P.;  Sun X.;  Chaggan C.;  Liao Z.;  Wong K.I.;  He F.;  Singh S.;  Loomba R.;  Karin M.;  Witztum J.L.;  Saltiel A.R.
收藏  |  浏览/下载：65/0  |  提交时间：2020/07/28
6,7 dihydro 4 hydroxy 3 (2' hydroxy 1,1' biphenyl 4 yl) 6 oxothieno[2,3 b]pyridine 5 carbonitrile  adenosine phosphate  caspase 3  caspase 6  caspase 7  cytochrome c  hydroxymethylglutaryl coenzyme A reductase kinase  matrix metalloproteinase  apoptosis  cytochrome  enzyme  enzyme activity  inhibition  protein  rodent  AMPK signaling  animal experiment  animal model  animal tissue  apoptosis  Article  C57BL 6 mouse  cell death  controlled study  drug mechanism  enzyme activation  enzyme activity  enzyme inhibition  enzyme phosphorylation  enzyme repression  gene knockout  human  human cell  human tissue  liver cell  liver fibrosis  liver injury  male  mouse  nonalcoholic steatohepatitis  nonhuman  priority journal  protein cleavage  protein secretion  
Programmed cell death along the midline axis patterns ipsilaterality in gastrulation 期刊论文
, 2020, 卷号: 367, 期号: 6474
作者:  Maya-Ramos L.;  Mikawa T.
收藏  |  浏览/下载：34/0  |  提交时间：2020/07/28
apoptosis  cell  embryonic development  functional role  inhibition  symmetry  transformation  apoptosis  article  bird  cell migration  cell transformation  embryo  extracellular matrix  gastrulation  germ layer  human  nonhuman  animal  cell motion  chick embryo  epithelial mesenchymal transition  transgenic animal  Animalia  Aves  green fluorescent protein  Animals  Animals, Genetically Modified  Apoptosis  Cell Movement  Chick Embryo  Epithelial-Mesenchymal Transition  Extracellular Matrix  Gastrulation  Green Fluorescent Proteins