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De novo design of protein logic gates 期刊论文
, 2020, 卷号: 368, 期号: 6486
作者:  Chen Z.;  Kibler R.D.;  Hunt A.;  Busch F.;  Pearl J.;  Jia M.;  VanAernum Z.L.;  Wicky B.I.M.;  Dods G.;  Liao H.;  Wilken M.S.;  Ciarlo C.;  Green S.;  El-Samad H.;  Stamatoyannopoulos J.;  Wysocki V.H.;  Jewett M.C.;  Boyken S.E.;  Baker D.
收藏  |  浏览/下载：24/0  |  提交时间：2020/07/28
cell  design method  gene expression  genetic analysis  protein  activation domain  Article  binding affinity  circular dichroism  controlled study  de novo design  design  DNA binding motif  enzyme activity  genetic transcription  human  human cell  hydrogen bond  hydrophobicity  mass spectrometry  native mass spectrometry  nonhuman  priority journal  protein protein interaction  protein structure  RNA translation  stoichiometry  thermodynamics  two hybrid system  X ray crystallography  chemistry  genetics  logic  metabolism  protein analysis  protein engineering  protein processing  synthetic biology  T lymphocyte  yeast  HAVCR2 protein, human  hepatitis A virus cellular receptor 2  Hepatitis A Virus Cellular Receptor 2  Humans  Logic  Mass Spectrometry  Protein Engineering  Protein Interaction Maps  Protein Processing, Post-Translational  Synthetic Biology  T-Lymphocytes  Transcription, Genetic  Yeasts  
Structural basis for strand-transfer inhibitor binding to HIV intasomes 期刊论文
, 2020, 卷号: 367, 期号: 6479
作者:  Passos D.O.;  Li M.;  Jóźwik I.K.;  Zhao X.Z.;  Santos-Martins D.;  Yang R.;  Smith S.J.;  Jeon Y.;  Forli S.;  Hughes S.H.;  Burke T.R.;  Jr.;  Craigie R.;  Lyumkis D.
收藏  |  浏览/下载：19/0  |  提交时间：2020/07/28
bictegravir  nucleoprotein  protein intasome  unclassified drug  viral protein  bictegravir  fused heterocyclic rings  integrase  integrase inhibitor  multiprotein complex  naphthyridine derivative  nucleoprotein  biochemistry  chemical binding  human immunodeficiency virus  inhibitor  protein  ultrastructure  amino terminal sequence  Article  carboxy terminal sequence  catalysis  cryoelectron microscopy  drug design  drug efficacy  drug protein binding  drug resistance  drug structure  enzyme active site  human  Human immunodeficiency virus infection  nonhuman  priority journal  protein purification  protein structure  antiviral resistance  chemistry  drug effect  genetics  Human immunodeficiency virus  virus DNA cell DNA interaction  Cryoelectron Microscopy  Drug Design  Drug Resistance, Viral  Heterocyclic Compounds, 4 or More Rings  HIV  HIV Integrase  HIV Integrase Inhibitors  Humans  Multiprotein Complexes  Naphthyridines  Nucleoproteins  Virus Integration